Phase I clinical and pharmacokinetic study of oxaliplatin, irinotecan and capecitabine
Smitha S Krishnamurthi, Joanna M Brell, Charles L Hoppel, Merrill J Egorin, Karen C Weaver, Xiaolin Li, Stephen T Ingalls, Eleanor G Zuhowski, Mark D Schluchter, Afshin Dowlati, Matthew M Cooney, Joseph Gibbons, Beth A Overmoyer, S Percy Ivy, Scot C Remick, Smitha S Krishnamurthi, Joanna M Brell, Charles L Hoppel, Merrill J Egorin, Karen C Weaver, Xiaolin Li, Stephen T Ingalls, Eleanor G Zuhowski, Mark D Schluchter, Afshin Dowlati, Matthew M Cooney, Joseph Gibbons, Beth A Overmoyer, S Percy Ivy, Scot C Remick
Abstract
Purpose: To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of the combination of weekly oxaliplatin x 4, weekly irinotecan x 4 and capecitabine Monday through Friday for 4 weeks of every 6 week cycle in patients with solid tumors; to determine the pharmacokinetic profile of these agents in this combination; to observe patients for clinical anti-tumor response.
Methods: Twenty-two patients with metastatic solid tumors received oxaliplatin 60 mg/m(2) weekly x 4, irinotecan beginning at a dose of 40 mg/m(2) weekly x 4, and capecitabine Monday through Friday for 4 weeks of every 6 week cycle, initially at 1,000 mg twice daily (bid).
Results: The MTD was oxaliplatin 60 mg/m(2) weekly x 4, irinotecan 50 mg/m(2) weekly x 4 and capecitabine 450 mg bid Monday through Friday for 4 weeks of every 6 week cycle. One of six patients at this dose level developed DLT of nausea, vomiting, and diarrhea. Among patients treated with a constant capecitabine dose of 450 mg bid, there was a higher mean AUC of 5-FU in women than in men (mean +/- SD: 892 +/- 287 nM h vs. 537 +/- 182 nM h; Mann-Whitney two-tailed, P = 0.02). There was one complete response in a patient with gastric cancer.
Conclusion: The novel schedule of weekly oxaliplatin, weekly irinotecan, and capecitabine Monday through Friday, all administered for 4 weeks of every 6 week cycle, evaluated in this phase I trial is well-tolerated and demonstrated activity in a patient with gastric cancer.
Source: PubMed