A four-day Western-style dietary intervention causes reductions in hippocampal-dependent learning and memory and interoceptive sensitivity

Tuki Attuquayefio, Richard J Stevenson, Megan J Oaten, Heather M Francis, Tuki Attuquayefio, Richard J Stevenson, Megan J Oaten, Heather M Francis

Abstract

In animals, a Western style diet-high in saturated fat and added sugar-causes impairments in hippocampal-dependent learning and memory (HDLM) and perception of internal bodily state (interoception). In humans, while there is correlational support for a link between Western-style diet, HDLM, and interoception, there is as yet no causal data. Here, healthy individuals were randomly assigned to consume either a breakfast high in saturated fat and added sugar (Experimental condition) or a healthier breakfast (Control condition), over four consecutive days. Tests of HDLM, interoception and biological measures were administered before and after breakfast on the days one and four, and participants completed food diaries before and during the study. At the end of the study, the Experimental condition showed significant reductions in HDLM and reduced interoceptive sensitivity to hunger and fullness, relative to the Control condition. The Experimental condition also showed a markedly different blood glucose and triglyceride responses to their breakfast, relative to Controls, with larger changes in blood glucose across breakfast being associated with greater reductions in HDLM. The Experimental condition compensated for their energy-dense breakfast by reducing carbohydrate intake, while saturated fat intake remained consistently higher than Controls. This is the first experimental study in humans to demonstrate that a Western-style diet impacts HDLM following a relatively short exposure-just as in animals. The link between diet-induced HDLM changes and blood glucose suggests one pathway by which diet impacts HDLM in humans.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1. HVLT scores.
Fig 1. HVLT scores.
Mean (± standard error) HVLT retention score (%) on test days one and four for the Experimental and Control groups.
Fig 2. Interoception scores.
Fig 2. Interoception scores.
Mean (± standard error) kilojoules (kJ) required to shift hunger and fullness ratings on days one and four for each group.
Fig 3. Blood glucose data.
Fig 3. Blood glucose data.
(A)—Mean (± standard error) pre- and post-prandial blood glucose levels at the start and end of the study for each group; (B)—Scatterplot of the negative linear relationship between HVLT retention score (%) by day (Day 4 –Day 1) and blood glucose levels (mg/dL) by time (post-breakfast–pre-breakfast).
Fig 4. Triglycerides data.
Fig 4. Triglycerides data.
Mean (± standard error) pre- and post-prandial triglyceride levels at the start and end of the study for each group.
Fig 5. Food diary data.
Fig 5. Food diary data.
An illustration of the compensation of energy intake across weeks and between groups, following the breakfast manipulation. Overall energy intake is greater in Week 2 relative to Week 1, with no differences between groups (i.e., caloric compensation).

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