Removal of Dolutegravir by Hemodialysis in HIV-Infected Patients with End-Stage Renal Disease
José Moltó, Fredzzia Graterol, Cristina Miranda, Saye Khoo, Ioana Bancu, Alieu Amara, Anna Bonjoch, Bonaventura Clotet, José Moltó, Fredzzia Graterol, Cristina Miranda, Saye Khoo, Ioana Bancu, Alieu Amara, Anna Bonjoch, Bonaventura Clotet
Abstract
Data on dolutegravir removal by hemodialysis are lacking. To study this, we measured dolutegravir plasma concentrations in samples of blood entering and leaving the dialyzer and of the resulting dialysate from 5 HIV-infected patients with end-stage renal disease. The median dolutegravir hemodialysis extraction ratio was 7%. The dolutegravir concentrations after the dialysis session remained far above the protein-binding-adjusted inhibitory concentration. Our results show minimal dolutegravir removal by hemodialysis, with no specific dolutegravir dosage adjustments required in this setting. (This study is registered at ClinicalTrials.gov under registration number NCT02487706.).
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Source: PubMed