Recommendations and guidelines for the treatment of Clostridioides difficile infection in Taiwan
Kuan-Sheng Wu, Ling-Shan Syue, Aristine Cheng, Ting-Yu Yen, Hsien-Meng Chen, Yu-Hsin Chiu, Yu-Lung Hsu, Chun-Hsiang Chiu, Ting-Yi Su, Wan-Lin Tsai, Wei-Yu Chen, Chung-Hao Huang, Huei-Min Hung, Ling-Ju Huang, Hong-Jie Kuo, Pei-Chin Lin, Ching-Hsiang Yang, Pi-Lien Hong, Susan Shin-Jung Lee, Yao-Shen Chen, Yung-Ching Liu, Li-Ming Huang, Infectious Diseases Society of Taiwan, Medical Foundation in Memory of Dr. Deh-Lin Cheng, Foundation of Professor Wei-Chuan Hsieh for Infectious Diseases Research and Education, CY Lee's Research Foundation for Pediatric Infectious Diseases and Vaccines, 5th Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) working group, Kuan-Sheng Wu, Ling-Shan Syue, Aristine Cheng, Ting-Yu Yen, Hsien-Meng Chen, Yu-Hsin Chiu, Yu-Lung Hsu, Chun-Hsiang Chiu, Ting-Yi Su, Wan-Lin Tsai, Wei-Yu Chen, Chung-Hao Huang, Huei-Min Hung, Ling-Ju Huang, Hong-Jie Kuo, Pei-Chin Lin, Ching-Hsiang Yang, Pi-Lien Hong, Susan Shin-Jung Lee, Yao-Shen Chen, Yung-Ching Liu, Li-Ming Huang, Infectious Diseases Society of Taiwan, Medical Foundation in Memory of Dr. Deh-Lin Cheng, Foundation of Professor Wei-Chuan Hsieh for Infectious Diseases Research and Education, CY Lee's Research Foundation for Pediatric Infectious Diseases and Vaccines, 5th Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) working group
Abstract
Clostridioides difficile infection (CDI) is a major enteric disease associated with antibiotic use and a leading cause of hospital-acquired infections worldwide. This is the first guideline for treatment of CDI in Taiwan, aiming to optimize medical care for patients with CDI. The target audience of this document includes all healthcare personnel who are involved in the medical care of patients with CDI. The 2018 Guidelines Recommendations for Evidence-based Antimicrobial agents use in Taiwan (GREAT) working group was formed, comprising of infectious disease specialists from 13 medical centers in Taiwan, to review the evidence and draft recommendations using the grading of recommendations assessment, development, and evaluation (GRADE) methodology. A nationwide expert panel reviewed the recommendations during a consensus meeting in March 2019. The recommendation is endorsed by the Infectious Diseases Society of Taiwan (IDST). This guideline describes the epidemiology and risk factors of CDI, and provides recommendations for treatment of CDI in both adults and children. Recommendations for treatment of the first episode of CDI, first recurrence, second and subsequent recurrences of CDI, severe CDI, fulminant CDI, and pediatric CDI are provided.
Keywords: CDI; Clostridium difficile; Diarrhea; Infectious diarrhea.
Conflict of interest statement
Declaration of Competing Interest All authors declare no conflict of interest.
Copyright © 2020. Published by Elsevier B.V.
Source: PubMed