A review on development of MUC1-based cancer vaccine
Tong Gao, Qianhong Cen, Han Lei, Tong Gao, Qianhong Cen, Han Lei
Abstract
Mucin 1 (MUC1) is a transmembrane mucin glycoprotein expressed on the surface of almost all epithelial cells. Aberrantly glycosylated MUC1 is associated with cellular transformation from a normal to malignant phenotype in human cancers. Therefore, MUC1 is the major target for the design and development of cancer vaccines. MUC1-based cancer vaccines are a promising strategy for preventing cancer progression and metastasis. This review summarizes the most significant milestones achieved to date in the development of different MUC-1-based vaccine approaches in clinical trials. Further, it provides perspectives for future research that may promote clinical advances in infection-associated cancers.
Keywords: Clinical trials; Infection-associated cancers; MUC1-based vaccine.
Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
Source: PubMed