Seasonal influenza vaccine policy, use and effectiveness in the tropics and subtropics - a systematic literature review

Siddhivinayak Hirve, Philipp Lambach, John Paget, Katelijn Vandemaele, Julia Fitzner, Wenqing Zhang, Siddhivinayak Hirve, Philipp Lambach, John Paget, Katelijn Vandemaele, Julia Fitzner, Wenqing Zhang

Abstract

Aim: The evidence needed for tropical countries to take informed decisions on influenza vaccination is scarce. This article reviews policy, availability, use and effectiveness of seasonal influenza vaccine in tropical and subtropical countries.

Method: Global health databases were searched in three thematic areas - policy, availability and protective benefits in the context of human seasonal influenza vaccine in the tropics and subtropics. We excluded studies on monovalent pandemic influenza vaccine, vaccine safety, immunogenicity and uptake, and disease burden.

Results: Seventy-four countries in the tropics and subtropics representing 60% of the world's population did not have a national vaccination policy against seasonal influenza. Thirty-eight countries used the Northern Hemisphere and 21 countries the Southern Hemisphere formulation. Forty-six countries targeted children and 57 targeted the elderly; though, the age cut-offs varied. Influenza vaccine supply increased twofold in recent years. However, coverage remained lower than five per 1000 population. Vaccine protection against laboratory-confirmed influenza in the tropics ranged from 0% to 42% in the elderly, 20-77% in children and 50-59% in healthy adults. Vaccinating pregnant women against seasonal influenza prevented laboratory-confirmed influenza in both mothers (50%) and their infants <6 months (49-63%).

Conclusion: Guidelines on vaccine composition, priority risk groups and vaccine availability varied widely. The evidence on vaccine protection was scarce. Countries in the tropics and subtropics need to strengthen and expand their evidence-base required for making informed decisions on influenza vaccine introduction and expansion, and how much benefit to expect.

Keywords: Influenza vaccines; policy; treatment effectiveness.

© 2016 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

Figures

Figure 1
Figure 1
PRISMA flowchart of selection and exclusion of articles.
Figure 2
Figure 2
Countries in the tropics and subtropics with a national influenza immunization policy.
Figure 3
Figure 3
National guidelines on seasonal influenza vaccine formulation for countries in the tropics and subtropics. NH, Northern Hemisphere; SH, Southern Hemisphere.
Figure 4
Figure 4
Seasonal influenza vaccine doses distributed in the tropics and subtropics (2011) (Source: adapted from Ref. 32).

References

    1. Gerdil C. The annual production cycle for influenza vaccine. Vaccine 2003; 21:1776–1779.
    1. Lozano R, Naghavi M, Foreman K et al Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380:2095–2128.
    1. Zhou H, Thompson WW, Viboud CG et al Hospitalizations associated with influenza and respiratory syncytial virus in the United States, 1993–2008. Clin Infect Dis 2012; 54:1427–1436.
    1. Nair H, Brooks WA, Katz M et al Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta‐analysis. Lancet 2011; 378:1917–1930.
    1. Gessner BD, Shindo N, Briand S. Seasonal influenza epidemiology in sub‐Saharan Africa: a systematic review. Lancet Infect Dis 2011; 11:223–235.
    1. WHO Unicef World Bank . State of the World's Vaccines and Immunization, 3rd ed Geneva: World Health Organization, 2009.
    1. World Health Organization . Resolution 56.19. Prevention and Control of Influenza Pandemics and Annual Epidemics. Geneva, Switzerland: World Health Organization, 2003.
    1. World Health Organization . Resolution WHA58.5. Strengthening Pandemic‐Influenza Preparedness and Response. Geneva, Switzerland: World Health Organization, 2005.
    1. World Health Organization . Report of the Second WHO Consultation on the Global Action Plan for Influenza Vaccines (GAP), Geneva, Switzerland, 12–14 July 2011. Geneva: World Health Organization, 2012.
    1. Abbott A. Flu jabs urged for developing countries. Nature 2009; 460:156–157.
    1. Kieny MP, Tam JS, Hendriks J. Progress update on the global action plan for influenza vaccines (GAP). Options for the control of Influenza VIII; Cape Town, South Africa, 2013; P1–P408.
    1. Macroepidemiology of Influenza Vaccination Study G . The macro‐epidemiology of influenza vaccination in 56 countries, 1997–2003. Vaccine 2005; 23:5133–5143.
    1. van Essen GA, Palache AM, Forleo E, Fedson DS. Influenza vaccination in 2000: recommendations and vaccine use in 50 developed and rapidly developing countries. Vaccine 2003; 21:1780–1785.
    1. World Health Organization . Vaccines against influenza WHO position paper – November 2012. Wkly Epidemiol Rec 2012; 47:461–476.
    1. Saha S, Chadha M, Al Mamun A et al Influenza seasonality and vaccination timing in tropical and subtropical areas of southern and south‐eastern Asia. Bull World Health Organ 2014; 92:318–330.
    1. Durand L, Cheng P, Palekar R et al Timing of influenza epidemics and vaccines in the American Tropics, 2002–2008, 2011–2014. Influenza and other respir viruses 2016. doi: .
    1. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P . Preferred reporting items for systematic reviews and meta‐analyses: the PRISMA Statement. Open Med 2009; 3:e123–e130.
    1. Breteler JK, Tam JS, Jit M, Ket JC, De Boer MR. Efficacy and effectiveness of seasonal and pandemic A (H1N1) 2009 influenza vaccines in low and middle income countries: a systematic review and meta‐analysis. Vaccine 2013; 31:5168–5177.
    1. Wells GA, Shea B, O'Connell D et al The Newcastle‐Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta‐analyses. Available at (Accessed 28 November 2014).
    1. Collaboration C . Part 2: General methods for Cochrane reviews. 2011. Cochrane Handbook for Systematic Reviews of Interventions [Internet]. Available at (Accessed 28 November 2014).
    1. World Health Organization . Global Survey on Seasonal Influenza Vaccine Policy Development and Implementation – 2010: Report of Findings. Geneva: World Health Organization, 2013.
    1. Cortes MdlA, Cardoso D, Fitzgerald J, DiFabio JL. Public vaccine manufacturing capacity in the Latin American and Caribbean region: current status and perspectives. Biologicals 2012; 40:3–14.
    1. Mato Chaín G, Mariano Lázaro A, Alcudia Pérez F, Verdejo Bravo C. Vacunación antigripal en personas mayores. Rev Esp Geriatr Gerontol 2011; 46:89–95.
    1. Music T. Protecting patients, protecting healthcare workers: a review of the role of influenza vaccination. Int Nurs Rev 2012; 59:161–167.
    1. Ng S, Wu P, Nishiura H, Ip DK, Lee ES, Cowling BJ. An analysis of national target groups for monovalent 2009 pandemic influenza vaccine and trivalent seasonal influenza vaccines in 2009–10 and 2010–11. BMC Infect Dis 2011; 11:230.
    1. Ropero‐Alvarez AM, Kurtis HJ, Danovaro‐Holliday MC, Ruiz‐Matus C, Andrus JK. Expansion of seasonal influenza vaccination in the Americas. BMC Public Health 2009; 9:361.
    1. Ahmed QA, Arabi YM, Memish ZA. Health risks at the Hajj. Lancet 2006; 367:1008–1015.
    1. World Health Organization . Health conditions for travellers to Saudi Arabia for the pilgrimage to Mecca (Hajj), 2014. Wkly Epidemiol Rec 2014; 89:357–360.
    1. Collin N, de Radigues X, World Health Organization HNVTF . Vaccine production capacity for seasonal and pandemic (H1N1) 2009 influenza. Vaccine 2009; 27:5184–5186.
    1. Palache A, Oriol‐Mathieu V, Abelin A, Music T, Influenza Vaccine Supply task f . Seasonal influenza vaccine dose distribution in 157 countries (2004–2011). Vaccine 2014; 32:6369–6376.
    1. Partridge J, Kieny MP, World Health Organization HNivTF . Global production of seasonal and pandemic (H1N1) influenza vaccines in 2009–2010 and comparison with previous estimates and global action plan targets. Vaccine 2010; 28:4709–4712.
    1. Feng L, Mounts AW, Feng Y et al Seasonal influenza vaccine supply and target vaccinated population in China, 2004–2009. Vaccine 2010; 28:6778–6782.
    1. Hoa LK, Hiep LV, Be LV. Development of pandemic influenza vaccine production capacity in Viet Nam. Vaccine 2011; 29(Suppl 1):A34–A36.
    1. Surichan S, Wirachwong P, Supachaturas W et al Development of influenza vaccine production capacity by the Government Pharmaceutical Organization of Thailand: addressing the threat of an influenza pandemic. Vaccine 2011; 29(Suppl 1):A29–A33.
    1. Friede M, Palkonyay L, Alfonso C et al WHO initiative to increase global and equitable access to influenza vaccine in the event of a pandemic: supporting developing country production capacity through technology transfer. Vaccine 2011; 29(Suppl 1):A2–A7.
    1. World Health Organization . Global action plan for influenza vaccines. Global progress report. January 2006–September 2013 March 2014. Available at (Accessed 28 November 2014).
    1. Partridge J, Kieny MP. Global production capacity of seasonal influenza vaccine in 2011. Vaccine 2013; 31:728–731.
    1. Schoub BD, Gessner BD, Ampofo W, Cohen AL, Steffen CA. Afriflu2–second international workshop on influenza vaccination in the African continent–8 November 2012, Cape Town (South Africa). Vaccine 2013; 31:3461–3466.
    1. Duque J, McMorrow ML, Cohen AL. Influenza vaccines and influenza antiviral drugs in Africa: are they available and do guidelines for their use exist? BMC Public Health 2014; 14:41.
    1. Nichol KL, Treanor JJ. Vaccines for seasonal and pandemic influenza. J Infect Dis 2006; 194(Suppl 2):S111–S118.
    1. Gupta V, Dawood FS, Muangchana C et al Influenza vaccination guidelines and vaccine sales in southeast Asia: 2008–2011. PLoS ONE 2012; 7:e52842.
    1. Praditsuwan R, Assantachai P, Wasi C, Puthavatana P, Kositanont U. The efficacy and effectiveness of influenza vaccination among Thai elderly persons living in the community. J Med Assoc Thai 2005; 88:256–264.
    1. De Villiers PJ, Steele AD, Hiemstra LA et al Efficacy and safety of a live attenuated influenza vaccine in adults 60 years of age and older. Vaccine 2009; 28:228–234.
    1. Ho HP, Zhao X, Pang J et al Effectiveness of seasonal influenza vaccinations against laboratory‐confirmed influenza‐associated infections among Singapore military personnel in 2010–2013. Influenza Other Respir Viruses 2014; DOI: .
    1. Ntshoe GM, McAnerney JM, Tempia S et al Influenza epidemiology and vaccine effectiveness among patients with influenza‐like illness, viral watch sentinel sites, South Africa, 2005–2009. PLoS ONE 2014; 9:e94681.
    1. McAnerney JM, Walaza S, Buys A et al Effectiveness of seasonal influenza vaccine in preventing laboratory confirmed influenza in a primary health care setting in South Africa, 2010–2012. Options for control of influenza VIII; Cape Town, South Africa, 2013; P1–P409.
    1. Cowling BJ, Ng S, Ma ES et al Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong. Clin Infect Dis 2010; 51:1370–1379.
    1. Jain VK, Rivera L, Zaman K et al Vaccine for prevention of mild and moderate‐to‐severe influenza in children. N Engl J Med 2013; 369:2481–2491.
    1. Bracco Neto H, Farhat CK, Tregnaghi MW et al Efficacy and safety of 1 and 2 doses of live attenuated influenza vaccine in vaccine‐naive children. Pediatr Infect Dis J 2009; 28:365–371.
    1. Tam JS, Capeding MR, Lum LC et al Efficacy and safety of a live attenuated, cold‐adapted influenza vaccine, trivalent against culture‐confirmed influenza in young children in Asia. Pediatr Infect Dis J 2007; 26:619–628.
    1. Lum LC, Borja‐Tabora CF, Breiman RF et al Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children. Vaccine 2010; 28:1566–1574.
    1. Belshe RB, Edwards KM, Vesikari T et al Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med 2007; 356:685–696.
    1. He Q, Xu J, Chen X et al Effectiveness of seasonal influenza vaccine against clinically diagnosed influenza over 2 consecutive seasons in children in Guangzhou, China: a matched case‐control study. Hum Vaccin Immunother 2013; 9:1720–1724.
    1. Fu C, He Q, Li Z et al Seasonal influenza vaccine effectiveness among children, 2010–2012. Influenza Other Respir Viruses 2013; 7:1168–1174.
    1. Yang Z, Dong Z, Fu C. Seasonal influenza vaccine effectiveness among children aged 6 to 59 months in southern China. PLoS ONE 2012; 7:e30424.
    1. Gattas VL, Cardoso MR, Machado CM, Mondini G, Luna EJ. Indirect effectiveness of vaccinating school children against influenza. Options for the control of influenza VIII; Cape Town, South Africa, 2013; P1–P388.
    1. Zaman K, Roy E, Arifeen SE et al Effectiveness of maternal influenza immunization in mothers and infants. N Engl J Med 2008; 359:1555–1564.
    1. Madhi SA, Cutland CL, Kuwanda L et al Influenza vaccination of pregnant women and protection of their infants. N Engl J Med 2014; 371:918–931.
    1. Kositanont U, Kanyok R, Wasi C, Wongsurakiat P, Suthamsmai T, Maranetra N. Occurrence and protective level of influenza infections using serology in patients with COPD in vaccination study. J Med Assoc Thai 2004; 87:964–969.
    1. Mereckiene J, Cotter S, D'Ancona F et al Differences in national influenza vaccination policies across the European Union, Norway and Iceland 2008–2009. Euro Surveill 2010; pii:19700.
    1. Beyer WE, McElhaney J, Smith DJ, Monto AS, Nguyen‐Van‐Tam JS, Osterhaus AD. Cochrane re‐arranged: support for policies to vaccinate elderly people against influenza. Vaccine 2013; 31:6030–6033.
    1. Darvishian M, Gefenaite G, Turner RM et al After adjusting for bias in meta‐analysis seasonal influenza vaccine remains effective in community‐dwelling elderly. J Clin Epidemiol 2014; 67:734–744.
    1. Luksic I, Clay S, Falconer R et al Effectiveness of seasonal influenza vaccines in children – a systematic review and meta‐analysis. Croat Med J 2013; 54:135–145.
    1. Tricco AC, Chit A, Soobiah C et al Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta‐analysis. BMC Med 2013; 11:153.
    1. Osterholm MT, Kelley NS, Sommer A, Belongia EA. Efficacy and effectiveness of influenza vaccines: a systematic review and meta‐analysis. Lancet Infect Dis 2012; 12:36–44.
    1. DiazGranados CA, Denis M, Plotkin S. Seasonal influenza vaccine efficacy and its determinants in children and non‐elderly adults: a systematic review with meta‐analyses of controlled trials. Vaccine 2012; 31:49–57.
    1. Michiels B, Govaerts F, Remmen R, Vermeire E, Coenen S. A systematic review of the evidence on the effectiveness and risks of inactivated influenza vaccines in different target groups. Vaccine 2011; 29:9159–9170.
    1. Carter NJ, Curran MP. Live attenuated influenza vaccine (FluMist(R); Fluenz): a review of its use in the prevention of seasonal influenza in children and adults. Drugs 2011; 71:1591–1622.
    1. Rhorer J, Ambrose CS, Dickinson S et al Efficacy of live attenuated influenza vaccine in children: a meta‐analysis of nine randomized clinical trials. Vaccine 2009; 27:1101–1110.
    1. Jefferson T, Rivetti A, Harnden A, Di Pietrantonj C, Demicheli V. Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev 2012, DOI: .
    1. Manzoli L, Schioppa F, Boccia A, Villari P. The efficacy of influenza vaccine for healthy children: a meta‐analysis evaluating potential sources of variation in efficacy estimates including study quality. Pediatr Infect Dis J 2007; 26:97–106.
    1. Negri E, Colombo C, Giordano L, Groth N, Apolone G, La Vecchia C. Influenza vaccine in healthy children: a meta‐analysis. Vaccine 2005; 23:2851–2861.
    1. Ruben FL. Inactivated influenza virus vaccines in children. Clin Infect Dis 2004; 38:678–688.
    1. Demicheli V, Di Pietrantonj C, Jefferson T, Rivetti A, Rivetti D. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev, 2007, DOI: .
    1. Centers for Disease Control and Prevention . Seasonal influenza vaccine effectiveness, 2005–2015. 2015. Available at (Accessed 21 December 2015).
    1. Organización Panamericana de la Salud . Vigilancia regional de la influenza, OPS‐OMS. Influenza y otros virus respiratorios bajo vigilancia, 2010–2014 [Internet]. 2014. Available at (Accessed 28 November 2014).
    1. de Lataillade C, Auvergne S, Delannoy I. 2005 and 2006 seasonal influenza vaccination coverage rates in 10 countries in Africa, Asia Pacific, Europe, Latin America and the Middle East. J Public Health Policy 2009; 30:83–101.
    1. Lee CL, Chen TY, Chih YC, Chou SM, Chen CH, Yang CH. The overview of government‐funded influenza vaccination program during influenza season 2011–2012. Options for control of Influenza VIII; Cape Town, South Africa, 2013; P1–P407.
    1. Owusu JT, Prapasiri P, Ditsungnoen D et al Seasonal influenza vaccine coverage by risk group in Thailand, 2010–2012. Options for control of influenza VIII; Cape Town, South Africa, 2013; P2–P498.
    1. Stamboulian D, Bonvehi PE, Nacinovich FM, Ruttimann RW. Immunization against influenza in the elderly: the Argentinian experience, 1993–1997. Vaccine 1999; 17(Suppl 1):S53–S56.
    1. Luna EJ, Gattas VL. Effectiveness of the Brazilian influenza vaccination policy, a systematic review. Rev Inst Med Trop Sao Paulo 2010; 52:175–181.
    1. Cabral MHdP. A campanha nacional de vacinação de idosos como estartégia de entrada do Programa de Saúde da Família em uma área programática de saúde do município do Rio de Janeiro‐RJ: planejamento, implementação e execução. Cad Saúde Colet 2006; 14:425–434.
    1. Cesar JA, Oliveira‐Filho JA, Bess G et al Perfil dos idosos residentes em dois municípios pobres das regiões Norte e Nordeste do Brasil: resultados de estudo transversal de base populacional. Cad Saude Publica 2008; 24:1835–1845.
    1. Donalisio MR, Ruiz T, Cordeiro R. Factors associated with influenza vaccination among elderly persons in Southeastern Brazil. Rev Saude Publica 2006; 40:115–119.
    1. Francisco P, Donalisio MR, Barros MBdA, César CLG, Carandina L, Goldbaum M. Fatores associados à vacinação contra a influenza em idosos. Rev Panam Salud Publica 2006; 19:259–264.
    1. Francisco P, DonalisioI MR, de Azevedo MB, CésarII CLG, CarandinaIII L, GoldbaumIV M. Fatores associados à doença pulmonar em idosos. Rev Saude Publica 2006; 40:428–435.
    1. Francisco PMSB, Donalisio MR, Barros MBdA, Cesar CLG, Carandina L, Goldbaum M. Vacinação contra influenza em idosos por área de residência: prevalência e fatores associados. Rev Bras Epidemiol 2006; 9:162–171.
    1. Lima‐Costa MF. Fatores associados à vacinação contra gripe em idosos na região metropolitana de Belo Horizonte. Rev Saude Publica 2008; 42:100–107.
    1. Geronutti DA, Molina AC, Lima SAM. Vacinação de idosos contra a influenza em um centro de saúde escola do interior do estado de São Paulo. Texto Contexto Enferm 2008; 17:336–341.
    1. Gutierrez EB, Li HY, Santos AC, Lopes MH. Effectiveness of influenza vaccination in elderly outpatients in Sao Paulo city, Brazil. Rev Inst Med Trop Sao Paulo 2001; 43:317–320.
    1. Santos BRLd, Creutzberg M, Cardoso RF et al Situação vacinal e associação com a qualidade de vida, a funcionalidade ea motivação para o autocuidado em idosos. Rev Bras Epidemiol 2009; 12:533–540.
    1. Koul PA, Bali NK, Ali S et al Poor uptake of influenza vaccination in pregnancy in northern India. Int J Gynaecol Obstet 2014; 127:234–237.
    1. Lau JT, Cai Y, Tsui HY, Choi KC. Prevalence of influenza vaccination and associated factors among pregnant women in Hong Kong. Vaccine 2010; 28:5389–5397.
    1. Yuet Sheung Yuen C, Yee Tak Fong D, Lai Yin Lee I, Chu S, Sau‐Mei Siu E, Tarrant M. Prevalence and predictors of maternal seasonal influenza vaccination in Hong Kong. Vaccine 2013; 31:5281–5288.
    1. Bellei N, Carraro E, Perosa AH, Benfica D, Granato CF. Influenza and rhinovirus infections among health‐care workers. Respirology 2007; 12:100–103.
    1. Takayanagi IJ, Cardoso MRA, Costa SF, Araya MES, Machado CM. Attitudes of health care workers to influenza vaccination: why are they not vaccinated? Am J Infect Control 2007; 35:56–61.
    1. Chan TC, Hung IF, Luk JK, Woo PC, Chu LW, Chan FH. Prevalence of influenza vaccination and associated factors in Chinese nursing home healthcare workers. J Am Geriatr Soc 2013; 61:1824–1827.
    1. Forrest BD, Steele AD, Hiemstra L, Rappaport R, Ambrose CS, Gruber WC. A prospective, randomized, open‐label trial comparing the safety and efficacy of trivalent live attenuated and inactivated influenza vaccines in adults 60 years of age and older. Vaccine 2011; 29:3633–3639.
    1. Isahak I, Mahayiddin AA, Ismail R. Effectiveness of influenza vaccination in prevention of influenza‐like illness among inhabitants of old folk homes. Southeast Asian J Trop Med Public Health 2007; 38:841–848.
    1. Plasai V, Lertmaharit S, Viputsiri OA et al Influenza vaccination among the elderly in Bangkok. Southeast Asian J Trop Med Public Health 2006; 37(Suppl 3):140–144.
    1. Jianping H, Xin F, Changshun L et al Assessment of effectiveness of Vaxigrip. Vaccine 1999; 17(Suppl 1):S57–S58.
    1. Jefferson T, Di Pietrantonj C, Al‐Ansary L, Ferroni E, Thorning S, Thomas R. Vaccines for preventing influenza in the elderly (Review). Cochrane Database Syst Rev 2010; 2010: Art. No.: CD004876.
    1. Gross PA, Hermogenes AW, Sacks HS, Lau J, Levandowski RA. The efficacy of influenza vaccine in elderly persons. A meta‐analysis and review of the literature. Ann Intern Med 1995; 123:518–527.
    1. Hung IF, Leung AY, Chu DW et al Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study. Clin Infect Dis 2010; 51:1007–1016.
    1. Moreno J, De la Hoz F, Rico A, Cotes K, Porras A. Effectiveness of the Influenza vaccine: meta‐analysis of literature. Biomedica 2009; 29:87–97.
    1. Rivetti D, Jefferson T, Thomas R et al Vaccines for preventing influenza in the elderly. Cochrane Database Syst Rev 2006; DOI: .
    1. Vu T, Farish S, Jenkins M, Kelly H. A meta‐analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community. Vaccine 2002; 20:1831–1836.
    1. Façanha MC. Influenza vaccination of individuals over the age of 60: impact on hospital admissions and deaths from respiratory and circulatory diseases in Fortaleza, Brazil. J Bras Pneumol 2005; 31:415–420.
    1. Brondi L, Barbosa J. (eds). Vacina contra influenza: experiencia en Brasil. Resúmenes de lo 12° Congreso Latinoamericano de Pediatria‐taller sobre imunizaciones; 2000.
    1. Daufenbach LZ, Carmo EH, Duarte EC, Campagna AdS, Teles CAS. Morbidade hospitalar por causas relacionadas à influenza em idosos no Brasil, 1992 a 2006. 2009.
    1. Ferrer AL, Marcon SS, Santana RG. Hospital morbidity among elderly patients, before and after influenza vaccination in the state of Parana. Rev Lat Am Enfermagem 2008; 16:832–837.
    1. Francisco PMSB, Donalisio MR, Latorre MdRDdO. Internações por doenças respiratórias em idosos ea intervenção vacinal contra influenza no Estado de São Paulo. Rev Bras Epidemiol 2004; 7:220–227.
    1. van Vuuren A, Rheeder P, Hak E. Effectiveness of influenza vaccination in the elderly in South Africa. Epidemiol Infect 2009; 137:994–1002.
    1. El Omeiri N, Azziz‐Baumgartner E, Clará 'W et al Pilot to evaluate the feasibility of measuring seasonal influenza vaccine effectiveness using surveillance platforms in Central‐America, 2012. BMC Public Health 2015; 15:673.
    1. Dawood FS, Prapasiri P, Areerat P et al Effectiveness of the 2010 and 2011 Southern Hemisphere trivalent inactivated influenza vaccines against hospitalization with influenza‐associated acute respiratory infection among Thai adults aged >/= 50 years. Influenza Other Respir Viruses 2014; 8:463–468.
    1. Wang CS, Wang ST, Lai CT, Lin LJ, Chou P. Impact of influenza vaccination on major cause‐specific mortality. Vaccine 2007; 25:1196–1203.
    1. Yung CF, Chan S, Tan A, Leo YS. A novel approach using vaccinated cases only to evaluate influenza vaccine effectiveness against all‐cause hospital admissions in the tropics. Options for control of influenza VIII; Cape Town, South Africa, 2013; P2–P527.
    1. Yung CF, Win MK, Tan A, Leo YS. Using vaccinated cases only to evaluate influenza vaccine effectiveness against death following admission to the hospital in the tropics. Options for control of influenza VIII; Cape Town, South Africa, 2013; P2–P526.
    1. Antunes JL, Waldman EA, Borrell C, Paiva TM. Effectiveness of influenza vaccination and its impact on health inequalities. Int J Epidemiol 2007; 36:1319–1326.
    1. Francisco PMSB, Donalisio MRdC, Lattorre MdRDd. Impact of influenza vaccination on mortality by respiratory diseases among Brazilian elderly persons. Rev Saude Publica 2005; 39:75–81.
    1. Chan TC, Fan‐Ngai Hung I, Ka‐Hay Luk J, Chiu‐Yat Woo P, Chu LW, Hon‐Wai Chan F. Efficacy of trivalent seasonal influenza vaccination in reducing mortality and hospitalization in Chinese nursing home older adults. J Am Med Dir Assoc 2013; 14:889–894.
    1. Victor JC, Diallo A, Niang MN et al Effectiveness of seasonal influenza vaccination of children in tropical developing Africa: a cluster‐randomized trial. Options for control of influenza VIII; Cape Town, South Africa, 2013; O–860.
    1. Kittikraisak W, Suntarattiwong P, Levy J et al Influenza vaccination coverage and effectiveness in young children in Thailand, 2011–2013. Influenza Other Respir Viruses 2015; 9:85–93.
    1. Jefferson T, Di Pietrantonj C, Rivetti A, Bawazeer GA, Al‐Ansary LA, Ferroni E. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev 2010; 7: DOI: .
    1. Hui LS, Rashwan H, bin Jaafar MH, Hussaini HM, Isahak DI. Effectiveness of influenza vaccine in preventing influenza‐like illness among Faculty of Dentistry staff and students in Universiti Kebangsaan Malaysia. Healthc Infect 2008; 13:4–9.
    1. Samad AH, Usul MH, Zakaria D et al Workplace vaccination against influenza in Malaysia: does the employer benefit? J Occup Health 2006; 48:1–10.
    1. Morales A, Martinez MM, Tasset‐Tisseau A, Rey E, Baron‐Papillon F, Follet A. Costs and benefits of influenza vaccination and work productivity in a Colombian company from the employer's perspective. Value Health 2004; 7:433–441.
    1. Galvao TF, Silva MT, Zimmermann IR, Lopes LA, Bernardo EF, Pereira MG. Influenza vaccination in pregnant women: a systematic review. ISRN Prev Med 2013; 2013:879493.
    1. Omer SB, Bednarczyk R, Madhi SA, Klugman KP. Benefits to mother and child of influenza vaccination during pregnancy. Hum Vaccin Immunother 2012; 8:130–137.
    1. Blanchard‐Rohner G, Siegrist CA. Vaccination during pregnancy to protect infants against influenza: why and why not? Vaccine 2011; 29:7542–7550.
    1. Skowronski DM, De Serres G. Is routine influenza immunization warranted in early pregnancy? Vaccine 2009; 27:4754–4770.
    1. Naleway AL, Smith WJ, Mullooly JP. Delivering influenza vaccine to pregnant women. Epidemiol Rev 2006; 28:47–53.
    1. Mak TK, Mangtani P, Leese J, Watson JM, Pfeifer D. Influenza vaccination in pregnancy: current evidence and selected national policies. Lancet Infect Dis 2008; 8:44–52.
    1. Steinhoff MC, MacDonald N, Pfeifer D, Muglia LJ. Influenza vaccine in pregnancy: policy and research strategies. Lancet 2014; 383:1611–1613.
    1. Poole PJ, Chacko E, Wood‐Baker RW, Cates CJ. Influenza vaccine for patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006; DOI: .
    1. Menon B, Gurnani M, Aggarwal B. Comparison of outpatient visits and hospitalisations, in patients with chronic obstructive pulmonary disease, before and after influenza vaccination. Int J Clin Pract 2008; 62:593–598.
    1. Wongsurakiat P, Maranetra KN, Wasi C, Kositanont U, Dejsomritrutai W, Charoenratanakul S. Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. Chest 2004; 125:2011–2020.
    1. Keller T, Weeda VB, van Dongen CJ, Levi M. Influenza vaccines for preventing coronary heart disease. Cochrane Database Syst Rev 2008; DOI: .
    1. Phrommintikul A, Kuanprasert S, Wongcharoen W, Kanjanavanit R, Chaiwarith R, Sukonthasarn A. Influenza vaccination reduces cardiovascular events in patients with acute coronary syndrome. Eur Heart J 2011; 32:1730–1735.
    1. Gurfinkel EP, Leon de la Fuente R, Mendiz O, Mautner B. Flu vaccination in acute coronary syndromes and planned percutaneous coronary interventions (FLUVACS) Study. Eur Heart J 2004; 25:25–31.
    1. Anema A, Mills E, Montaner J, Brownstein JS, Cooper C. Efficacy of influenza vaccination in HIV‐positive patients: a systematic review and meta‐analysis. HIV Med 2008; 9:57–61.
    1. Atashili J, Kalilani L, Adimora AA. Efficacy and clinical effectiveness of influenza vaccines in HIV‐infected individuals: a meta‐analysis. BMC Infect Dis 2006; 6:138.
    1. Madhi SA, Maskew M, Koen A et al Trivalent inactivated influenza vaccine in African adults infected with human immunodeficient virus: double blind, randomized clinical trial of efficacy, immunogenicity, and safety. Clin Infect Dis 2011; 52:128–137.
    1. Thomas RE, Jefferson T, Lasserson TJ. Influenza vaccination for healthcare workers who care for people aged 60 or older living in long‐term care institutions. Cochrane Database Syst Rev 2013; 7:CD005187.
    1. Kheok SW, Chong CY, McCarthy G et al The efficacy of influenza vaccination in healthcare workers in a tropical setting: a prospective investigator blinded observational study. Ann Acad Med Singapore 2008; 37:465–469.
    1. Qureshi H, Gessner BD, Leboulleux D, Hasan H, Alam SE, Moulton LH. The incidence of vaccine preventable influenza‐like illness and medication use among Pakistani pilgrims to the Haj in Saudi Arabia. Vaccine 2000; 18:2956–2962.
    1. Mustafa AN, Gessner BD, Ismail R et al A case‐control study of influenza vaccine effectiveness among Malaysian pilgrims attending the Haj in Saudi Arabia. Int J Infect Dis 2003; 7:210–214.

Source: PubMed

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