Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study
Kevin L Steiner, Mamun Kabir, Jeffrey W Priest, Biplob Hossain, Carol A Gilchrist, Heather Cook, Jennie Z Ma, Poonum S Korpe, Tahmeed Ahmed, A S G Faruque, Rashidul Haque, William A Petri, Kevin L Steiner, Mamun Kabir, Jeffrey W Priest, Biplob Hossain, Carol A Gilchrist, Heather Cook, Jennie Z Ma, Poonum S Korpe, Tahmeed Ahmed, A S G Faruque, Rashidul Haque, William A Petri
Abstract
In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.
Keywords: Cp23; IgA; cryptosporidiosis; fecal; mucosal.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
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References
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