Eurycoma longifolia Jack in managing idiopathic male infertility

Mohd Ismail Bin Mohd Tambi, M Kamarul Imran, Mohd Ismail Bin Mohd Tambi, M Kamarul Imran

Abstract

This study investigated the effect of treatment with the proprietary standardized, water-soluble extract of the root of the Malaysian plant, Eurycoma longifolia Jack, which is thought to enhance male fertility with regard to higher semen volumes, sperm concentrations, the percentage of normal sperm morphology and sperm motility in male partners of sub-fertile couples with idiopathic infertility. A total of 350 patients were given 200 mg of the extract daily and follow-up semen analyses were performed every 3 months for 9 months. Of these 350 patients, 75 patients completed one full cycle of 3 months. Follow-up semen analyses in these patients showed significant improvement in all semen parameters. The proprietary extract of Eurycoma longifolia Jack significantly improved the sperm quality in these patients, allowing for 11 (14.7%) spontaneous pregnancies.

Figures

Figure 1
Figure 1
Increase in seminal sperm concentration after treatment with a 100 mg twice daily dose of the proprietary standardized water-soluble extract of Eurycoma longifolia Jack root. A distinct continuous increase in sperm concentration after the treatment can be seen from baseline to the first, second and third cycles. All values are mean ± SE.
Figure 2
Figure 2
Increase in the percentage of sperm with normal morphology after treatment with a 100 mg twice daily dose of the proprietary standardized water-soluble extract of Eurycoma longifolia Jack root. A significant improvement in sperm morphology after the treatment can be seen from the baseline to the first, second and third cycles. All values are mean ± SE.
Figure 3
Figure 3
Increase in seminal volume after treatment with a 100 mg twice daily dose of the proprietary standardized water-soluble extract of Eurycoma longifolia Jack root. A distinct, continuous increase in seminal volume after treatment can be seen from baseline to the first, second and third cycles. All values are mean ± SE.

References

    1. Mahdi AA, Bano F, Singh R, Singh RK, Siddiqui MS, et al. Seminal plasma superoxide dismutase and catalase activities in infertile men. Med Sci Res. 1999;27:201–3.
    1. Bano F, Singh RK, Singh R, Siddiqui MS, Mahdi AA. Seminal plasma lipid peroxide levels in infertile men. J Endocrinol Reprod. 1999;3:20–8.
    1. Sikka SC. Relative impact of oxidative stress on male reproductive function. Curr Med Chem. 2001;8:851–62.
    1. Burkill IH, Hanif M. Malay village medicine, prescriptions collected. Gardens Bulletin Strait Settlements. 1930;6:176–7.
    1. Ali JM, Saad JM.Biochemical effect of Eurycoma Longifolia Jack on the sexual behavior, fertility, sex hormone and glycolysis [Dissertation]Department of Biochemistry, University of Malaya. 1993
    1. Ang HH, Sim MK. Eurycoma longifolia increases sexual motivation in sexually naive male rats. Arch Pharm Res. 1998;21:779–81.
    1. Ang HH, Sim MK. Eurycoma longifolia Jack and orientation activities in sexually experienced male rats. Biol Pharm Bull. 1998;21:153–5.
    1. Ang HH, Sim MK. Eurycoma Longifolia Jack increases sexual motivation in sexually naive male rats. Archives of Pharmacal Research. 1998;21:778–81.
    1. Kuo PC, Damu AG, Lee KH, Wu TS. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg Med Chem. 2004;12:537–44.
    1. Jiwajinda S, Santisopasri V, Murakami A, Sugiyama H, Gasquet M, et al. In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol. 2002;82:55–8.
    1. Hamzah S, Yusof A. The ergogenic effects of Tongkat Ali (Eurycoma Longifolia) Br J Sports Med. 2003;37:465–66.
    1. Asiah O, Nurhanan MY, Ilham MA. Determination of bioactive peptide (4.3 kDa) as an aphrodisiac marker in six Malaysia plants. J Tropical Forest Sci. 2007;19:61–3.
    1. Sambandan TG, Rha C, Kadir AA, Aminudim N, Saad JM.Bioactive fraction of Eurycoma longifoliaUS Patent: US7, 132,117 B2 2006.
    1. Tambi MI.Glycoprotein water-soluble extract of Eurycoma Longifolia Jack as a health supplement in management of Health aging in aged menIn: Lunenfeld B, editor. Abstracts of the 3rd World Congress on the Aging Male, February 7–10, 2002, Berlin, Germany. Aging Male 2002; 6. [Abstract].
    1. Tambi MI.Water soluble Extract of Eurycoma Longifolia in enhancing testosterone in malesIn: Proceeding of International Trade Show and Conference, Supply Side West, The Venetian, Las Vegas, Nevada, USA. 2003 Oct 1–3.
    1. Tambi MI.Standardized water soluble extract of Eurycoma Longifolia (LJ100) on men's healthIn: Abstracts of the 8th International Congress of Andrology, 12–16 June 2005, Seoul, Korea. Int J Androl 200528Suppl 127.
    1. Tambi MI.Standardized water soluble extract of Eurycoma Longifolia LJ100 maintains healthy aging in manIn: Lunenfeld B, editor. Abstracts of the 5th World Congress on the Aging Male. February 9-12, 2006, Salzburg, Austria. Aging Male 20069Abstract]
    1. Tambi MI. Eurycoma Longifolia jack: a potent adaptogen in the form of water-soluble extract with the effect of maintaining men's health. Asian J Androl. 2006;8 Suppl 1:49–50.
    1. World Health Organization (WHO)Laboratory Manual for the Examination of Human Semen and Sperm–Cervical Mucus InteractionNew York: Cambridge University Press; 1999
    1. Lenzi A, Picardo M, Gandini L, Dondero F. Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy. Hum Reprod Update. 1996;2:246–56.
    1. Lenzi A, Lombardo F, Sgro P, Salacone P, Caponecchia L, et al. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. Fertil Steril. 2003;79:292–300.
    1. Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of male infertility. Int J Urol. 2009;16:449–57.
    1. Kruger TF, Coetzee K. The role of sperm morphology in assisted reproduction. Hum Reprod Update. 1999;5:172–8.
    1. Burr RW, Siegberg R, Flaherty SP, Wang XJ, Matthews CD. The influence of sperm morphology and the number of motile sperm inseminated on the outcome of intrauterine insemination combined with mild ovarian stimulation. Fertil Steril. 1996;65:127–32.
    1. Mortimer D, Menkveld R. Sperm morphology assessment—historical perspectives and current opinions. J Androl. 2001;22:192–205.
    1. Henkel R, Maaß G, Bödeker RH, Scheibelhut C, Stalf T, et al. Sperm function and assisted reproduction technology. Reprod Med Biol. 2005;4:7–30.

Source: PubMed

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