Cystic fibrosis bone disease treatment: Current knowledge and future directions
Melissa S Putman, Abeer Anabtawi, Trang Le, Vin Tangpricha, Isabelle Sermet-Gaudelus, Melissa S Putman, Abeer Anabtawi, Trang Le, Vin Tangpricha, Isabelle Sermet-Gaudelus
Abstract
Bone disease is a frequent complication in adolescents and adults with cystic fibrosis (CF). Early detection and monitoring of bone mineral density and multidisciplinary preventive care are necessary from childhood through adolescence to minimize CF-related bone disease (CFBD) in adult CF patients. Approaches to optimizing bone health include ensuring adequate nutrition, particularly intake of calcium and vitamins D and K, addressing other secondary causes of low bone density such as hypogonadism, encouraging weight bearing exercise, and avoiding bone toxic medications. Of the currently available anti-resorptive or anabolic osteoporosis medications, only bisphosphonates have been studied in individuals with CF. Future studies are needed to better understand the optimal approach for managing CFBD.
Keywords: Bisphosphonates; Bone mineral density; Cystic fibrosis; Dual energy x-ray absorptiometry; Fracture; Vitamin D.
Copyright © 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Source: PubMed