Critical Care Cardiology Trials Network (CCCTN): a cohort profile

Thomas S Metkus, Vivian M Baird-Zars, Carlos E Alfonso, Carlos L Alviar, Christopher F Barnett, Gregory W Barsness, David D Berg, Mia Bertic, Erin A Bohula, James Burke, Barry Burstein, Sunit-Preet Chaudhry, Howard A Cooper, Lori B Daniels, Christopher B Fordyce, Shahab Ghafghazi, Michael Goldfarb, Jason N Katz, Ellen C Keeley, Norma M Keller, Benjamin Kenigsberg, Michael C Kontos, Younghoon Kwon, Patrick R Lawler, Evan Leibner, Shuangbo Liu, Venu Menon, P Elliott Miller, L Kristin Newby, Connor G O'Brien, Alexander I Papolos, Matthew J Pierce, Rajnish Prasad, Barbara Pisani, Brian J Potter, Robert O Roswell, Shashank S Sinha, Kevin S Shah, Timothy D Smith, R Jeffrey Snell, Derek So, Michael A Solomon, Bradley W Ternus, Jeffrey J Teuteberg, Sean van Diepen, Sammy Zakaria, David A Morrow, Thomas S Metkus, Vivian M Baird-Zars, Carlos E Alfonso, Carlos L Alviar, Christopher F Barnett, Gregory W Barsness, David D Berg, Mia Bertic, Erin A Bohula, James Burke, Barry Burstein, Sunit-Preet Chaudhry, Howard A Cooper, Lori B Daniels, Christopher B Fordyce, Shahab Ghafghazi, Michael Goldfarb, Jason N Katz, Ellen C Keeley, Norma M Keller, Benjamin Kenigsberg, Michael C Kontos, Younghoon Kwon, Patrick R Lawler, Evan Leibner, Shuangbo Liu, Venu Menon, P Elliott Miller, L Kristin Newby, Connor G O'Brien, Alexander I Papolos, Matthew J Pierce, Rajnish Prasad, Barbara Pisani, Brian J Potter, Robert O Roswell, Shashank S Sinha, Kevin S Shah, Timothy D Smith, R Jeffrey Snell, Derek So, Michael A Solomon, Bradley W Ternus, Jeffrey J Teuteberg, Sean van Diepen, Sammy Zakaria, David A Morrow

Abstract

Aims: The aims of the Critical Care Cardiology Trials Network (CCCTN) are to develop a registry to investigate the epidemiology of cardiac critical illness and to establish a multicentre research network to conduct randomised clinical trials (RCTs) in patients with cardiac critical illness.

Methods and results: The CCCTN was founded in 2017 with 16 centres and has grown to a research network of over 40 academic and clinical centres in the United States and Canada. Each centre enters data for consecutive cardiac intensive care unit (CICU) admissions for at least 2 months of each calendar year. More than 20 000 unique CICU admissions are now included in the CCCTN Registry. To date, scientific observations from the CCCTN Registry include description of variations in care, the epidemiology and outcomes of all CICU patients, as well as subsets of patients with specific disease states, such as shock, heart failure, renal dysfunction, and respiratory failure. The CCCTN has also characterised utilization patterns, including use of mechanical circulatory support in response to changes in the heart transplantation allocation system, and the use and impact of multidisciplinary shock teams. Over years of multicentre collaboration, the CCCTN has established a robust research network to facilitate multicentre registry-based randomised trials in patients with cardiac critical illness.

Conclusion: The CCCTN is a large, prospective registry dedicated to describing processes-of-care and expanding clinical knowledge in cardiac critical illness. The CCCTN will serve as an investigational platform from which to conduct randomised controlled trials in this important patient population.

Keywords: Cardiac ICU; Cohort; Critical care; Epidemiology.

© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.

Figures

Figure 1
Figure 1
Schematic of the Cardiology Critical Care Trials Network.
Figure 2
Figure 2
(A) Geography of Cardiology Critical Care Trials Network sites with relative volume of data contributed; (B) Cumulative number of patients entered in Cardiology Critical Care Trials Network over time.

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Source: PubMed

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