Diagnosis of autoimmune gastritis by high resolution magnification endoscopy

George-K Anagnostopoulos, Krish Ragunath, Anthony Shonde, Christopher J Hawkey, Kenshi Yao, George-K Anagnostopoulos, Krish Ragunath, Anthony Shonde, Christopher J Hawkey, Kenshi Yao

Abstract

Endoscopic visualisation of gastric atrophy is usually not feasible with conventional endoscopy. Magnifying endoscopy is helpful to analyze the subepithelial microvascular architecture as well as the mucosal surface microstructure without tissue biopsy. Using this technique we were able to describe the normal gastric microvasculature pattern and we also identified characteristic patterns in two cases of autoimmune atrophic gastritis.

Figures

Figure 1
Figure 1
A: Magnified view of gastric antral mucosa in our patient. All parts of the antral mucosa demonstrated a coil-shaped subepithelial capillary network (SECN) in regular arrangement; B: Magnified endoscopic view of the gastric body mucosa in our patient. Loss of the normal SECN and collecting venules (arrows) in irregular shape and arrangement were evident. These findings are compatible with those of gastric atrophy; C: Histology reveales decreased density of glands, loss of specialised glands in the gastric body; D: Magnified view of normal gastric body mucosa in another healthy patient Honeycomb-like SECN with collecting venules in regular arrangement can be seen clearly.

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Source: PubMed

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