Utilization of Magnesium for the Treatment of Chronic Pain

Ivan Urits, Jai Won Jung, Ariunzaya Amgalan, Luc Fortier, Anthony Anya, Brendan Wesp, Vwaire Orhurhu, Elyse M Cornett, Alan D Kaye, Farnad Imani, Giustino Varrassi, Henry Liu, Omar Viswanath, Ivan Urits, Jai Won Jung, Ariunzaya Amgalan, Luc Fortier, Anthony Anya, Brendan Wesp, Vwaire Orhurhu, Elyse M Cornett, Alan D Kaye, Farnad Imani, Giustino Varrassi, Henry Liu, Omar Viswanath

Abstract

Context: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs.

Evidence acquisition: Narrative review.

Results: There are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction.

Conclusions: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain.

Keywords: Abdominal Pain; Chronic Pain; Chronic Regional Pain Syndrome; Infusion; Intravenous; Magnesium Sulfate; Peripheral Neuropathy.

Conflict of interest statement

Conflict of Interests: None.

Copyright © 2021, Author(s).

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Source: PubMed

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