Metacognitive training for psychosis (MCT): past, present, and future

Steffen Moritz, Mahesh Menon, Ryan Balzan, Todd S Woodward, Steffen Moritz, Mahesh Menon, Ryan Balzan, Todd S Woodward

Abstract

This article provides an overview and retrospective on metacognitive training for psychosis (MCT), which first appeared approximately 2 decades ago. We recount how our empirical understanding of psychosis at that time led to the first preliminary version of the program. We describe setbacks and challenges that led to major changes, including revisions to existing modules (e.g., more focus on metacognitive variables, particularly on decision confidence as one of the primary targets of treatment) and the creation of new modules addressing mood, as well as attempts to improve sustainability of effects via homework exercises and a smartphone app ( www.uke.de/mct_app ). We have also enhanced dissemination efforts by creating new culturally sensitive language versions and facilitating low-threshold training through e-learning courses ( www.uke.de/e-mct ). Finally, we discuss several meta-analyses on the efficacy of MCT that have been published over the last decade. While reviews were initially inconsistent, possibly reflecting the insufficient statistical power and lower design quality of the first MCT studies, more recent meta-analyses have confirmed the efficacy of MCT on positive symptoms, insight, and cognitive biases, which has led to the inclusion of MCT in some national treatment guidelines for schizophrenia.

Keywords: Cognitive biases; Metacognitive training; Psychosis; Schizophrenia; Social cognition.

Conflict of interest statement

The authors have contributed to the development of metacognitive training.

© 2022. The Author(s).

References

    1. Liddle PF. Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol Med. 1987;17:49–57. doi: 10.1017/S0033291700012976.
    1. Abramovitch A, Short T, Schweiger A. The C factor: cognitive dysfunction as a transdiagnostic dimension in psychopathology. Clin Psychol Rev. 2021;86:102007. doi: 10.1016/j.cpr.2021.102007.
    1. Garety PA, Freeman D. Cognitive approaches to delusions: a critical review of theories and evidence. Br J Clin Psychol. 1999;38:113–154. doi: 10.1348/014466599162700.
    1. Pohl RF. Cognitive illusions. A handbook on fallacies and biases in thinking, judgement and memory. Hove: Psychology Press; 2004.
    1. Sharot T. The optimism bias. Curr Biol. 2011;21:941–945. doi: 10.1016/j.cub.2011.10.030.
    1. Kahneman D, Tversky A. On the reality of cognitive illusions. Psychol Rev. 1996;103:582–591. doi: 10.1037/0033-295X.103.3.582.
    1. Huq SF, Garety PA, Hemsley DR. Probabilistic judgements in deluded and non-deluded subjects. Q J Exp Psychol A. 1988;40:801–812. doi: 10.1080/14640748808402300.
    1. Woodward TS, Moritz S, Cuttler CC, Whitman JC. A generalized cognitive deficit in integrating disconfirmatory evidence underlies delusion maintenance in schizophrenia. Schizophr Res. 2004;67:79.
    1. Moritz S, Woodward TS. Plausibility judgement in schizophrenic patients: evidence for a liberal acceptance bias. Ger J Psychiatry. 2004;7:66–74.
    1. Moritz S, Woodward TS. Memory confidence and false memories in schizophrenia. J Nerv Ment Dis. 2002;190:641–643. doi: 10.1097/00005053-200209000-00012.
    1. Kinderman P, Bentall RP. A new measure of causal locus: the internal, personal and situational attributions questionnaire. Personal Individ Differ. 1996;20:261–264. doi: 10.1016/0191-8869(95)00186-7.
    1. Moritz S, Woodward TS. A generalized bias against disconfirmatory evidence in schizophrenia. Psychiatry Res. 2006;142:157–165. doi: 10.1016/j.psychres.2005.08.016.
    1. Woodward TS, Moritz S, Cuttler C, Whitman JC. The contribution of a cognitive bias against disconfirmatory evidence (BADE) to delusions in schizophrenia. J Clin Exp Neuropsychol. 2006;28:605–617. doi: 10.1080/13803390590949511.
    1. Garety PA, Freeman D. The past and future of delusions research: from the inexplicable to the treatable. Br J Psychiatry. 2013;203:327–333. doi: 10.1192/bjp.bp.113.126953.
    1. Freeman D, Garety P, Kuipers E, et al. Delusions and decision-making style: use of the need for closure scale. Behav Res Ther. 2006;44:1147–1158. doi: 10.1016/j.brat.2005.09.002.
    1. Moritz S, Balzan RP, Bohn F, et al. Subjective versus objective cognition: evidence for poor metacognitive monitoring in schizophrenia. Schizophr Res. 2016;178:74–79. doi: 10.1016/j.schres.2016.08.021.
    1. Balzan RP, Neaves A, Denson LA, et al. Cognitive deficit awareness in schizophrenia: absent, intact, or somewhere in-between? Cogn Neuropsychiatry. 2014;19:471–484. doi: 10.1080/13546805.2014.909311.
    1. Koriat A. Metacognition research: an interim report. In: Perfect TJ, Schwartz BL, editors. Applied metacognition. Cambridge: Cambridge University Press; 2002. pp. 261–286.
    1. Capobianco L, Wells A. Letter to the editor: Metacognitive therapy or metacognitive training: What’s in a name? J Behav Ther Exp Psychiatry. 2018;59:161. doi: 10.1016/j.jbtep.2017.12.003.
    1. Moritz S, Lysaker PH. Metacognition: what did James H. Flavell really say and the implications for the conceptualization and design of metacognitive interventions. Schizophr Res. 2018;201:20–26. doi: 10.1016/j.schres.2018.06.001.
    1. Moritz S, Klein JP, Lysaker PH, Mehl S. Metacognitive and cognitive-behavioral interventions for psychosis: new developments. Dialogues Clin Neurosci. 2019;21:309–317. doi: 10.31887/DCNS.2019.21.3/smoritz.
    1. Mendelson D, Thibaudeau É, Sauvé G, et al. Remote group therapies for cognitive health in schizophrenia-spectrum disorders: feasible, acceptable, engaging. Schizophr Res Cognit. 2021 doi: 10.1016/J.SCOG.2021.100230.
    1. Lüdtke T, Pult LK, Schröder J, et al. A randomized controlled trial on a smartphone self-help application (Be Good to Yourself) to reduce depressive symptoms. Psychiatry Res. 2018;269:753–762. doi: 10.1016/j.psychres.2018.08.113.
    1. Bruhns A, Lüdtke T, Moritz S, Bücker L (2021) The self-esteem booster: a randomized controlled trial investigating a mobile-based intervention in students with depressive symptoms. JMIR mHealth uHealth (in press)
    1. Taleb NN. The black swan: the impact of the highly improbable. 2. London: Penguin; 2010.
    1. Kahneman D. Thinking, fast and slow. New York: Farrar, Straus and Giroux; 2011.
    1. Balzan RP, Delfabbro PH, Galletly CA, Woodward TS. Metacognitive training for patients with schizophrenia: preliminary evidence for a targeted, single-module programme. Aust N Z J Psychiatry. 2014;48:1126–1136. doi: 10.1177/0004867413508451.
    1. Jiang J, Zhang L, Zhu Z, et al. Metacognitive training for schizophrenia: a systematic review. Shanghai Arch Psychiatry. 2015;27:149–157.
    1. Oosterhout B, Smit F, Krabbendam L, et al. Letter to the editor: should we focus on quality or quantity in meta-analyses? Psychol Med. 2016;46:2003–2005. doi: 10.1017/S003329171600009X.
    1. van Oosterhout B, Krabbendam L, de Boer K, et al. Metacognitive group training for schizophrenia spectrum patients with delusions: a randomized controlled trial. Psychol Med. 2014;44:3025–3035. doi: 10.1017/S0033291714000555.
    1. Moritz S, Veckenstedt R, Randjbar S, et al. Antipsychotic treatment beyond antipsychotics: metacognitive intervention for schizophrenia patients improves delusional symptoms. Psychol Med. 2011;41:1823–1832. doi: 10.1017/S0033291710002618.
    1. Balzan R, Mattiske J, Delfabbro P, et al. Individualised metacognitive training (MCT+) reduces delusional symptoms in psychosis: a randomized clinical trial. Schizophr Bull. 2019 doi: 10.1093/schbul/sby152.
    1. Köther U, Vettorazzi E, Veckenstedt R, et al. Bayesian analyses of the effect of Metacognitive Training on social cognition deficits and overconfidence in errors. J Exp Psychopathol. 2017;8:158–174. doi: 10.5127/jep.054516.
    1. Andreou C, Moritz S, Veith K, et al. Dopaminergic modulation of probabilistic reasoning and overconfidence in errors: a double-blind study. Schizophr Bull. 2013;40:558–565. doi: 10.1093/schbul/sbt064.
    1. Philipp R, Kriston L, Lanio J, et al. Effectiveness of metacognitive interventions for mental disorders in adults: a systematic review and meta-analysis (METACOG) Clin Psychol Psychother. 2019;26:227–240. doi: 10.1002/cpp.2345.
    1. Eichner C, Berna F. Acceptance and efficacy of metacognitive training (MCT) on positive symptoms and delusions in patients with schizophrenia: a meta-analysis taking into account important moderators. Schizophr Bull. 2016;42:952–962. doi: 10.1093/schbul/sbv225.
    1. Liu Y-C, Tang C-C, Hung T-T, et al. The efficacy of metacognitive training for delusions in patients with schizophrenia: a meta-analysis of randomized controlled trials informs evidence-based practice. Worldviews Evidence-Based Nurs. 2018;15:130–139. doi: 10.1111/wvn.12282.
    1. Sauvé G, Lavigne KM, Pochiet G, et al. Efficacy of psychological interventions targeting cognitive biases in schizophrenia: a systematic review and meta-analysis. Clin Psychol Rev. 2020;78:101854. doi: 10.1016/j.cpr.2020.101854.
    1. Lopez-Morinigo J-D, Ajnakina O, Martínez AS-E, et al. Can metacognitive interventions improve insight in schizophrenia spectrum disorders? A systematic review and meta-analysis. Psychol Med. 2020;50:2289–2301. doi: 10.1017/S0033291720003384.
    1. Penney D, Sauvé G, Mendelson D et al (2022) Effectiveness, durability, and moderators of metacognitive training for psychosis (MCT): a systematic review and meta-analysis. JAMA Psychiatry (in press)
    1. Byrne R, Davies L, Morrison AP. Priorities and preferences for the outcomes of treatment of psychosis: a service user perspective. Psychosis. 2010;2:210–217. doi: 10.1080/17522430903456913.
    1. Moritz S, Berna F, Jaeger S, et al. The customer is always right? Subjective target symptoms and treatment preferences in patients with psychosis. Eur Arch Psychiatry Clin Neurosci. 2017;267:335–339. doi: 10.1007/s00406-016-0694-5.
    1. Kuhnigk O, Slawik L, Meyer J, et al. Valuation and attainment of treatment goals in schizophrenia: perspectives of patients, relatives, physicians, and payers. J Psychiatric Pract. 2012;18:321–328. doi: 10.1097/01.pra.0000419816.75752.65.
    1. Moritz S, Göritz AS, McLean B, et al. Do depressive symptoms predict paranoia or vice versa? J Behav Ther Exp Psychiatry. 2017;56:113–121. doi: 10.1016/j.jbtep.2016.10.002.
    1. Moritz S, Rietschel L, Veckenstedt R, et al. The other side of “madness”: frequencies of positive and ambivalent attitudes towards prominent positive symptoms in psychosis. Psychosis. 2015;7:14–24. doi: 10.1080/17522439.2013.865137.
    1. Ishikawa R, Ishigaki T, Shimada T, et al. The efficacy of extended metacognitive training for psychosis: a randomized controlled trial. Schizophr Res. 2019 doi: 10.1016/j.schres.2019.08.006.
    1. Chen Q, Sang Y, Ren L, et al. Metacognitive training: a useful complement to community-based rehabilitation for schizophrenia patients in China. BMC Psychiatry. 2021;21:38. doi: 10.1186/s12888-021-03039-y.
    1. Acuña V, Otto A, Cavieres A, Villalobos H. Eficacia del entrenamiento metacognitivo en una muestra chilena de personas con esquizofrenia (efficacy of Metacognitive Training in a Chilean sample of people with schizophrenia) Rev Colomb Psiquiatr. 2021 doi: 10.1016/j.rcp.2020.12.006.
    1. Mehl S, Werner D, Lincoln TM. Does cognitive behavior therapy for psychosis (CBTp) show a sustainable effect on delusions? A meta-analysis. Front Psychol. 2015;6:1450. doi: 10.3389/fpsyg.2015.01450.

Source: PubMed

3
Se inscrever