Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch, Christophe Guignabert, Marc Humbert, Mark R Nicolls, Marlene Rabinovitch, Christophe Guignabert, Marc Humbert, Mark R Nicolls
Abstract
This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of pulmonary arterial hypertension. The chemokines and cytokines implicated in pulmonary arterial hypertension that could form a biomarker platform are discussed. Pre-clinical studies that provide the basis for dysregulated immunity in animal models of the disease are reviewed. In addition, we present therapies that target inflammatory/immune mechanisms that are currently enrolling patients, and discuss others in development. We show how genetic and metabolic abnormalities are inextricably linked to dysregulated immunity and adverse remodeling in the pulmonary arteries.
Keywords: hypertension, pulmonary; leukotriene B4.
Conflict of interest statement
Disclosures: The authors have no conflicts of interest to disclose
© 2014 American Heart Association, Inc.
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Source: PubMed