Nationwide surveillance of macrolide-resistant Mycoplasma pneumoniae infection in pediatric patients

Yasuhiro Kawai, Naoyuki Miyashita, Mika Kubo, Hiroto Akaike, Atsushi Kato, Yoko Nishizawa, Aki Saito, Eisuke Kondo, Hideto Teranishi, Tokio Wakabayashi, Satoko Ogita, Takaaki Tanaka, Kozo Kawasaki, Takashi Nakano, Kihei Terada, Kazunobu Ouchi, Yasuhiro Kawai, Naoyuki Miyashita, Mika Kubo, Hiroto Akaike, Atsushi Kato, Yoko Nishizawa, Aki Saito, Eisuke Kondo, Hideto Teranishi, Tokio Wakabayashi, Satoko Ogita, Takaaki Tanaka, Kozo Kawasaki, Takashi Nakano, Kihei Terada, Kazunobu Ouchi

Abstract

We conducted nationwide surveillance to investigate regional differences in macrolide-resistant (MR) Mycoplasma pneumoniae strains in Japan. The prevalence of MR M. pneumoniae in pediatric patients gradually increased between 2008 and 2012. Although regional differences were observed, high levels of MR genes were detected in all seven surveillance areas throughout Japan and ranged in prevalence from 50% to 93%. These regional differences were closely related to the previous administration of macrolides.

Figures

Fig 1
Fig 1
Samples were collected from pediatric patients with acute respiratory tract infections who visited 65 institutions located in 7 areas of Japan (shaded areas). (A) Kyushu; (B) Chugoku; (C) Shikoku; (D) Kinki; (E) Tokai; (F) Kanto; (G) Hokkaido; (H) Hokuriku; (I) Koshinetsu; (J) Tohoku.
Fig 2
Fig 2
Year-by-year increases in the frequency of macrolide-resistant Mycoplasma pneumoniae cases from 2008 to 2012.

Source: PubMed

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