Off-Pump Coronary Artery Bypass Grafting: 30 Years of Debate

Mario Gaudino, Gianni D Angelini, Charalambos Antoniades, Faisal Bakaeen, Umberto Benedetto, Antonio M Calafiore, Antonino Di Franco, Michele Di Mauro, Stephen E Fremes, Leonard N Girardi, David Glineur, Juan Grau, Guo-Wei He, Carlo Patrono, John D Puskas, Marc Ruel, Thomas A Schwann, Derrick Y Tam, James Tatoulis, Robert Tranbaugh, Michael Vallely, Marco A Zenati, Michael Mack, David P Taggart, Arterial Grafting International Consortium (ATLANTIC) Alliance, Mario Gaudino, Gianni D Angelini, Charalambos Antoniades, Faisal Bakaeen, Umberto Benedetto, Antonio M Calafiore, Antonino Di Franco, Michele Di Mauro, Stephen E Fremes, Leonard N Girardi, David Glineur, Juan Grau, Guo-Wei He, Carlo Patrono, John D Puskas, Marc Ruel, Thomas A Schwann, Derrick Y Tam, James Tatoulis, Robert Tranbaugh, Michael Vallely, Marco A Zenati, Michael Mack, David P Taggart, Arterial Grafting International Consortium (ATLANTIC) Alliance

No abstract available

Keywords: coronary artery bypass grafting; off‐pump; off‐pump coronary artery bypass.

References

    1. Goetz RH, Rohman M, Haller JD, Dee R, Rosenak SS. Internal mammary‐coronary artery anastomosis. A nonsuture method employing tantalum rings. J Thorac Cardiovasc Surg. 1961;41:378–386.
    1. Buffolo E, Andrade JC, Succi J, Leão LE, Gallucci C. Direct myocardial revascularization without cardiopulmonary bypass. Thorac Cardiovasc Surg. 1985;33:26–29.
    1. Benetti FJ, Naselli G, Wood M, Geffner L. Direct myocardial revascularization without extracorporeal circulation. Experience in 700 patients. Chest. 1991;100:312–316.
    1. Calafiore AM, Giammarco GD, Teodori G, Bosco G, D'Annunzio E, Barsotti A, Maddestra N, Paloscia L, Vitolla G, Sciarra A, Fino C, Contini M. Left anterior descending coronary artery grafting via left anterior small thoracotomy without cardiopulmonary bypass. Ann Thorac Surg. 1996;61:1658–1665.
    1. Angelini GD, Wilde P, Salerno TA, Bosco G, Calafiore AM. Integrated left small thoracotomy and angioplasty for multivessel coronary artery revascularisation. Lancet. 1996;347:757–758.
    1. Calafiore AM, Vitolla G, Mazzei V, Teodori G, Di Giammarco G, Iovino T, Iaco A. The LAST operation: techniques and results before and after the stabilization era. Ann Thorac Surg. 1998;66:998–1001.
    1. Calafiore AM, Teodori G, Di Giammarco G, Vitolla G, Maddestra N, Paloscia L, Zimarino M, Mazzei V. Multiple arterial conduits without cardiopulmonary bypass: early angiographic results. Ann Thorac Surg. 1999;67:450–456.
    1. Bergsland J, Karamanoukian HL, Soltoski PR, Salerno TA. “Single suture” for circumflex exposure in off‐pump coronary artery bypass grafting. Ann Thorac Surg. 1999;68:1428–1430.
    1. Yeatman M, Caputo M, Narayan P, Ghosh AK, Ascione R, Ryder I, Angelini GD. Intracoronary shunts reduce transient intraoperative myocardial dysfunction during off‐pump coronary operations. Ann Thorac Surg. 2002;73:1411–1417.
    1. Ohmes LB, Di Franco A, Di Giammarco G, Rosati CM, Lau C, Girardi LN, Massetti M, Gaudino M. Techniques for intraoperative graft assessment in coronary artery bypass surgery. J Thorac Dis. 2017;9:S327–S332.
    1. Moscarelli M, Harling L, Ashrafian H, Athanasiou T, Casula R. Challenges facing totally endoscopic robotic coronary artery bypass grafting. Int J Med Robot. 2015;11:18–29.
    1. Formica F, Mariani S, Broccolo F, Caruso R, Corti F, D'Alessandro S, Amigoni P, Sangalli F, Paolini G. Systemic and myocardial inflammatory response in coronary artery bypass graft surgery with miniaturized extracorporeal circulation: differences with a standard circuit and off‐pump technique in a randomized clinical trial. ASAIO J. 2013;59:600–606.
    1. Antoniades C, Demosthenous M, Reilly S, Margaritis M, Zhang M‐H, Antonopoulos A, Marinou K, Nahar K, Jayaram R, Tousoulis D, Bakogiannis C, Sayeed R, Triantafyllou C, Koumallos N, Psarros C, Miliou A, Stefanadis C, Channon KM, Casadei B. Myocardial redox state predicts in‐hospital clinical outcome after cardiac surgery effects of short‐term pre‐operative statin treatment. J Am Coll Cardiol. 2012;59:60–70.
    1. Wan IYP, Arifi AA, Wan S, Yip JHY, Sihoe ADL, Thung KH, Wong EMC, Yim APC. Beating heart revascularization with or without cardiopulmonary bypass: evaluation of inflammatory response in a prospective randomized study. J Thorac Cardiovasc Surg. 2004;127:1624–1631.
    1. Czerny M, Baumer H, Kilo J, Lassnigg A, Hamwi A, Vukovich T, Wolner E, Grimm M. Inflammatory response and myocardial injury following coronary artery bypass grafting with or without cardiopulmonary bypass. Eur J Cardiothorac Surg. 2000;17:737–742.
    1. Greilich PE, Brouse CF, Rinder HM, Jessen ME, Rinder CS, Eberhart RC, Whitten CW, Smith BR. Monocyte activation in on‐pump versus off‐pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth. 2008;22:361–368.
    1. Winterhalter M, Brandl K, Rahe‐Meyer N, Osthaus A, Hecker H, Hagl C, Adams HA, Piepenbrock S. Endocrine stress response and inflammatory activation during CABG surgery. A randomized trial comparing remifentanil infusion to intermittent fentanyl. Eur J Anaesthesiol. 2008;25:326–335.
    1. Nesher N, Frolkis I, Vardi M, Sheinberg N, Bakir I, Caselman F, Pevni D, Ben‐Gal Y, Sharony R, Bolotin G, Loberman D, Uretzky G, Weinbroum AA. Higher levels of serum cytokines and myocardial tissue markers during on‐pump versus off‐pump coronary artery bypass surgery. J Card Surg. 2006;21:395–402.
    1. Ghorbel MT, Cherif M, Mokhtari A, Bruno VD, Caputo M, Angelini GD. Off‐pump coronary artery bypass surgery is associated with fewer gene expression changes in the human myocardium in comparison with on‐pump surgery. Physiol Genomics. 2010;42:67–75.
    1. Rogers CA, Pike K, Angelini GD, Reeves BC, Glauber M, Ferrarini M, Murphy GJ. An open randomized controlled trial of median sternotomy versus anterolateral left thoracotomy on morbidity and health care resource use in patients having off‐pump coronary artery bypass surgery: the Sternotomy Versus Thoracotomy (STET) trial. J Thorac Cardiovasc Surg. 2013;146:306–309.
    1. Meng F, Ma J, Wang W, Lin B. Meta‐analysis of interleukin 6, 8, and 10 between off‐pump and on‐pump coronary artery bypass groups. Bosn J Basic Med Sci. 2017;17:85–94.
    1. Jongman RM, Zijlstra JG, Kok WF, van Harten AE, Mariani MA, Moser J, Struys MMRF, Absalom AR, Molema G, Scheeren TWL, van Meurs M. Off‐pump CABG surgery reduces systemic inflammation compared with on‐pump surgery but does not change systemic endothelial responses: a prospective randomized study. Shock. 2014;42:121–128.
    1. Bu X, Wang B, Wang Y, Wang Z, Gong C, Qi F, Zhang C. Pathway‐related modules involved in the application of sevoflurane or propofol in off‐pump coronary artery bypass graft surgery. Exp Ther Med. 2017;14:97–106.
    1. van Straten AHM, Soliman Hamad MA, van Zundert AJ, Martens EJ, Schönberger JPAM, de Wolf AM. Preoperative C‐reactive protein levels to predict early and late mortalities after coronary artery bypass surgery: eight years of follow‐up. J Thorac Cardiovasc Surg. 2009;138:954–958.
    1. Paschalis A, Tousoulis D, Demosthenous M, Antonopoulos A, Papaioannou S, Miliou A, Koumallos N, Antoniades C, Stefanadis C. Pre‐operative inflammation and post‐operative atrial fibrillation in coronary artery bypass surgery. Int J Cardiol. 2014;173:327–328.
    1. Gaudino M, Di Castelnuovo A, Zamparelli R, Andreotti F, Burzotta F, Iacoviello L, Glieca F, Alessandrini F, Nasso G, Donati MB, Maseri A, Schiavello R, Possati G. Genetic control of postoperative systemic inflammatory reaction and pulmonary and renal complications after coronary artery surgery. J Thorac Cardiovasc Surg. 2003;126:1107–1112.
    1. Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Paolasso E, Straka Z, Piegas LS, Akar AR, Jain AR, Noiseux N, Padmanabhan C, Bahamondes J‐C, Novick RJ, Vaijyanath P, Reddy S, Tao L, Olavegogeascoechea PA, Airan B, Sulling T‐A, Whitlock RP, Ou Y, Ng J, Chrolavicius S, Yusuf S; CORONARY Investigators . Off‐pump or on‐pump coronary‐artery bypass grafting at 30 days. N Engl J Med. 2012;366:1489–1497.
    1. Chaney MA. Corticosteroids and cardiopulmonary bypass: a review of clinical investigations. Chest. 2002;121:921–931.
    1. Radaelli A, Loardi C, Cazzaniga M, Balestri G, DeCarlini C, Cerrito MG, Cusa EN, Guerra L, Garducci S, Santo D, Menicanti L, Paolini G, Azzellino A, Lavitrano ML, Mancia G, Ferrari AU. Inflammatory activation during coronary artery surgery and its dose‐dependent modulation by statin/ACE‐inhibitor combination. Arterioscler Thromb Vasc Biol. 2007;27:2750–2755.
    1. Parolari A, Poggio P, Myasoedova V, Songia P, Pilozzi A, Alamanni F, Tremoli E. Molecular pathways activation in coronary artery bypass surgery: which role for pump avoidance? J Cardiovasc Med. 2016;17:54–61.
    1. Davì G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357:2482–2494.
    1. Cavalca V, Rocca B, Veglia F, Petrucci G, Porro B, Myasoedova V, De Cristofaro R, Turnu L, Bonomi A, Songia P, Cavallotti L, Zanobini M, Carmera M, Alamanni F, Parolari A, Patrono C, Tremoli E. On‐pump cardiac surgery enhances platelet renewal and impairs aspirin pharmacodynamics: effects of improved dosing regimens. Clin Pharmacol Ther. 2017;102:849–858.
    1. Zimmermann N, Kurt M, Wenk A, Winter J, Gams E, Hohlfeld T. Is cardiopulmonary bypass a reason for aspirin resistance after coronary artery bypass grafting? Eur J Cardiothorac Surg. 2005;27:606–610.
    1. Bochsen L, Rosengaard LB, Nielsen AB, Steinbrüchel DA, Johansson PI. Platelet hyperreactivity in response to on‐ and off‐pump coronary artery bypass grafting. J Extra Corpor Technol. 2009;41:15–19.
    1. Gielen CLI, Brand A, van Heerde WL, Stijnen T, Klautz RJM, Eikenboom J. Hemostatic alterations during coronary artery bypass grafting. Thromb Res. 2016;140:140–146.
    1. Ivert T, Dalén M, Ander C, Stålesen R, Näsman P, Lordkipanidzé M, Hjemdahl P. Platelet function one and three months after coronary bypass surgery in relation to once or twice daily dosing of acetylsalicylic acid. Thromb Res. 2017;149:64–69.
    1. Paikin JS, Hirsh J, Ginsberg JS, Weitz JI, Chan NC, Whitlock RP, Pare G, Eikelboom JW. Once versus twice daily aspirin after coronary bypass surgery: a randomized trial. J Thromb Haemost. 2017;15:889–896.
    1. Shroyer AL, Grover FL, Hattler B, Collins JF, McDonald GO, Kozora E, Lucke JC, Baltz JH, Novitzky D; Veterans Affairs Randomized On/Off Bypass (ROOBY) Study Group . On‐pump versus off‐pump coronary‐artery bypass surgery. N Engl J Med. 2009;361:1827–1837.
    1. Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Straka Z, Piegas LS, Avezum A, Akar AR, Lanas Zanetti F, Jain AR, Noiseux N, Padmanabhan C, Bahamondes J‐C, Novick RJ, Tao L, Olavegogeascoechea PA, Airan B, Sulling T‐A, Whitlock RP, Ou Y, Gao P, Pettit S, Yusuf S. Five‐year outcomes after off‐pump or on‐pump coronary‐artery bypass grafting. N Engl J Med. 2016;375:2359–2368.
    1. Shroyer AL, Hattler B, Wagner TH, Collins JF, Baltz JH, Quin JA, Almassi GH, Kozora E, Bakaeen F, Cleveland JC, Bishawi M, Grover FL. Five‐year outcomes after on‐pump and off‐pump coronary‐artery bypass. N Engl J Med. 2017;377:623–632.
    1. Diegeler A, Börgermann J, Kappert U, Breuer M, Böning A, Ursulescu A, Rastan A, Holzhey D, Treede H, Rieß F‐C, Veeckmann P, Asfoor A, Reents W, Zacher M, Hilker M; GOPCABE Study Group . Off‐pump versus on‐pump coronary‐artery bypass grafting in elderly patients. N Engl J Med. 2013;368:1189–1198.
    1. Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Paolasso E, Straka Z, Piegas LS, Akar AR, Jain AR, Noiseux N, Padmanabhan C, Bahamondes J‐C, Novick RJ, Vaijyanath P, Reddy SK, Tao L, Olavegogeascoechea PA, Airan B, Sulling T‐A, Whitlock RP, Ou Y, Pogue J, Chrolavicius S, Yusuf S; CORONARY Investigators . Effects of off‐pump and on‐pump coronary‐artery bypass grafting at 1 year. N Engl J Med. 2013;368:1179–1188.
    1. Polomsky M, He X, O'Brien SM, Puskas JD. Outcomes of off‐pump versus on‐pump coronary artery bypass grafting: impact of preoperative risk. J Thorac Cardiovasc Surg. 2013;145:1193–1198.
    1. Kuss O, von Salviati B, Börgermann J. Off‐pump versus on‐pump coronary artery bypass grafting: a systematic review and meta‐analysis of propensity score analyses. J Thorac Cardiovasc Surg. 2010;140:829–835, 835.e1–13.
    1. Lattouf OM, Thourani VH, Kilgo PD, Halkos ME, Baio KT, Myung R, Cooper WA, Guyton RA, Puskas JD. Influence of on‐pump versus off‐pump techniques and completeness of revascularization on long‐term survival after coronary artery bypass. Ann Thorac Surg. 2008;86:797–805.
    1. Di Mauro M, Gagliardi M, Iacò AL, Contini M, Bivona A, Bosco P, Gallina S, Calafiore AM. Does off‐pump coronary surgery reduce postoperative acute renal failure? The importance of preoperative renal function. Ann Thorac Surg. 2007;84:1496–1502.
    1. Kirmani BH, Holmes MV, Muir AD. Long‐term survival and freedom from reintervention after off‐pump coronary artery bypass grafting: a propensity‐matched study. Circulation. 2016;134:1209–1220.
    1. Filardo G, Grayburn PA, Hamilton C, Hebeler RF, Cooksey WB, Hamman B. Comparing long‐term survival between patients undergoing off‐pump and on‐pump coronary artery bypass graft operations. Ann Thorac Surg. 2011;92:571–578.
    1. Filardo G, Hamman BL, da Graca B, Sass DM, Machala NJ, Ismail S, Pollock BD, Collinsworth AW, Grayburn PA. Efficacy and effectiveness of on‐ versus off‐pump coronary artery bypass grafting: a meta‐analysis of mortality and survival. J Thorac Cardiovasc Surg. 2018;155:172–179.
    1. Smart NA, Dieberg G, King N. Long‐term outcomes of on‐ versus off‐pump coronary artery bypass grafting. J Am Coll Cardiol. 2018;71:983–991.
    1. Kowalewski M, Pawliszak W, Malvindi PG, Bokszanski MP, Perlinski D, Raffa GM, Kowalkowska ME, Zaborowska K, Navarese EP, Kolodziejczak M, Kowalewski J, Tarelli G, Taggart DP, Anisimowicz L. Off‐pump coronary artery bypass grafting improves short‐term outcomes in high‐risk patients compared with on‐pump coronary artery bypass grafting: meta‐analysis. J Thorac Cardiovasc Surg. 2016;151:58–60.
    1. Puskas JD, Thourani VH, Kilgo P, Cooper W, Vassiliades T, Vega JD, Morris C, Chen E, Schmotzer BJ, Guyton RA, Lattouf OM. Off‐pump coronary artery bypass disproportionately benefits high‐risk patients. Ann Thorac Surg. 2009;88:1142–1147.
    1. Dhurandhar V, Saxena A, Parikh R, Vallely MP, Wilson MK, Butcher JK, Black DA, Tran L, Reid CM, Bannon PG. Outcomes of on‐pump versus off‐pump coronary artery bypass graft surgery in the high risk (AusSCORE > 5). Heart Lung Circ. 2015;24:1216–1224.
    1. Keeling WB, Williams ML, Slaughter MS, Zhao Y, Puskas JD. Off‐pump and on‐pump coronary revascularization in patients with low ejection fraction: a report from the Society of Thoracic Surgeons national database. Ann Thorac Surg. 2013;96:83–89.
    1. Ueki C, Miyata H, Motomura N, Sakaguchi G, Akimoto T, Takamoto S. Off‐pump versus on‐pump coronary artery bypass grafting in patients with left ventricular dysfunction. J Thorac Cardiovasc Surg. 2016;151:1092–1098.
    1. Jarral OA, Saso S, Athanasiou T. Off‐pump coronary artery bypass in patients with left ventricular dysfunction: a meta‐analysis. Ann Thorac Surg. 2011;92:1686–1694.
    1. Shahian DM, O'Brien SM, Filardo G, Ferraris VA, Haan CK, Rich JB, Normand S‐LT, DeLong ER, Shewan CM, Dokholyan RS, Peterson ED, Edwards FH, Anderson RP; Society of Thoracic Surgeons Quality Measurement Task Force . The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 1–coronary artery bypass grafting surgery. Ann Thorac Surg. 2009;88:S2–S22.
    1. Khan H, Uzzaman M, Benedetto U, Butt S, Raja SG. On‐ or off‐pump coronary artery bypass grafting for octogenarians: a meta‐analysis of comparative studies involving 27,623 patients. Int J Surg. 2017;47:42–51.
    1. Houlind K, Kjeldsen BJ, Madsen SN, Rasmussen BS, Holme SJ, Nielsen PH, Mortensen PE; DOORS Study Group . On‐pump versus off‐pump coronary artery bypass surgery in elderly patients: results from the Danish on‐pump versus off‐pump randomization study. Circulation. 2012;125:2431–2439.
    1. Cavallaro P, Itagaki S, Seigerman M, Chikwe J. Operative mortality and stroke after on‐pump vs off‐pump surgery in high‐risk patients: an analysis of 83,914 coronary bypass operations. Eur J Cardiothorac Surg. 2014;45:159–164.
    1. Edwards FH, Carey JS, Grover FL, Bero JW, Hartz RS. Impact of gender on coronary bypass operative mortality. Ann Thorac Surg. 1998;66:125–131.
    1. Hannan EL, Bernard HR, Kilburn HC, O'Donnell JF. Gender differences in mortality rates for coronary artery bypass surgery. Am Heart J. 1992;123:866–872.
    1. Puskas JD, Kilgo PD, Kutner M, Pusca SV, Lattouf O, Guyton RA. Off‐pump techniques disproportionately benefit women and narrow the gender disparity in outcomes after coronary artery bypass surgery. Circulation. 2007;116:I192–I199.
    1. Puskas JD, Edwards FH, Pappas PA, O'Brien S, Peterson ED, Kilgo P, Ferguson TB. Off‐pump techniques benefit men and women and narrow the disparity in mortality after coronary bypass grafting. Ann Thorac Surg. 2007;84:1447–1456.
    1. Attaran S, Harling L, Ashrafian H, Moscarelli M, Casula R, Anderson J, Punjabi P, Athanasiou T. Off‐pump versus on‐pump revascularization in females: a meta‐analysis of observational studies. Perfusion. 2014;29:385–396.
    1. O'Brien SM, Shahian DM, Filardo G, Ferraris VA, Haan CK, Rich JB, Normand S‐LT, DeLong ER, Shewan CM, Dokholyan RS, Peterson ED, Edwards FH, Anderson RP; Society of Thoracic Surgeons Quality Measurement Task Force . The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2–isolated valve surgery. Ann Thorac Surg. 2009;88:S23–S42.
    1. Edwards FH, Ferraris VA, Shahian DM, Peterson E, Furnary AP, Haan CK, Bridges CR; Society of Thoracic Surgeons . Gender‐specific practice guidelines for coronary artery bypass surgery: perioperative management. Ann Thorac Surg. 2005;79:2189–2194.
    1. Mishra M, Malhotra R, Karlekar A, Mishra Y, Trehan N. Propensity case‐matched analysis of off‐pump versus on‐pump coronary artery bypass grafting in patients with atheromatous aorta. Ann Thorac Surg. 2006;82:608–614.
    1. Sharony R, Grossi EA, Saunders PC, Galloway AC, Applebaum R, Ribakove GH, Culliford AT, Kanchuger M, Kronzon I, Colvin SB. Propensity case‐matched analysis of off‐pump coronary artery bypass grafting in patients with atheromatous aortic disease. J Thorac Cardiovasc Surg. 2004;127:406–413.
    1. Zembala MO, Filipiak K, Ciesla D, Pacholewicz J, Hrapkowicz T, Knapik P, Przybylski R, Zembala M. Surgical treatment of left main disease and severe carotid stenosis: does the off‐pump technique provide a better outcome? Eur J Cardiothorac Surg. 2013;43:541–548; discussion 548.
    1. Mishra Y, Wasir H, Kohli V, Meharwal ZS, Malhotra R, Mehta Y, Trehan N. Concomitant carotid endarterectomy and coronary bypass surgery: outcome of on‐pump and off‐pump techniques. Ann Thorac Surg. 2004;78:2037–2043.
    1. Halkos ME, Puskas JD, Lattouf OM, Kilgo P, Guyton RA, Thourani VH. Impact of preoperative neurologic events on outcomes after coronary artery bypass grafting. Ann Thorac Surg. 2008;86:504–510; discussion 510.
    1. Kozora E, Kongs S, Collins JF, Hattler B, Baltz J, Hampton M, Grover FL, Novitzky D, Shroyer AL. Cognitive outcomes after on‐ versus off‐pump coronary artery bypass surgery. Ann Thorac Surg. 2010;90:1134–1141.
    1. Kim HJ, Kim JB, Jung S‐H, Choo SJ, Lee JW, Chung CH. Coronary artery bypass grafting in patients with severe chronic kidney disease: a propensity score‐weighted analysis on the impact of on‐pump versus off‐pump strategies. Eur J Cardiothorac Surg. 2017;52:937–944.
    1. Wang Y, Zhu S, Gao P, Zhou J, Zhang Q. Off‐pump versus on‐pump coronary surgery in patients with chronic kidney disease: a meta‐analysis. Clin Exp Nephrol. 2018;22:99–109.
    1. Chen J‐J, Lin L‐Y, Yang Y‐H, Hwang J‐J, Chen P‐C, Lin J‐L, Chi N‐H. On pump versus off pump coronary artery bypass grafting in patients with end‐stage renal disease and coronary artery disease—a nation‐wide, propensity score matched database analyses. Int J Cardiol. 2017;227:529–534.
    1. Lim JY, Deo SV, Jung SH, Altarabsheh SE, Erwin PJ, Dillon JJ, Park SJ. Does off‐pump coronary artery bypass confer any advantage in patients with end‐stage renal failure? A systematic review and meta‐analysis. Hear Lung Circ. 2015;24:55–61.
    1. Gopaldas RR, Chu D, Cornwell LD, Dao TK, Lemaire SA, Coselli JS, Bakaeen FG. Cirrhosis as a moderator of outcomes in coronary artery bypass grafting and off‐pump coronary artery bypass operations: a 12‐year population‐based study. Ann Thorac Surg. 2013;96:1310–1315.
    1. Hattler B, Messenger JC, Shroyer AL, Collins JF, Haugen SJ, Garcia JA, Baltz JH, Cleveland JC, Novitzky D, Grover FL. Off‐Pump coronary artery bypass surgery is associated with worse arterial and saphenous vein graft patency and less effective revascularization: results from the Veterans Affairs Randomized On/Off Bypass (ROOBY) trial. Circulation. 2012;125:2827–2835.
    1. Puskas JD, Williams WH, O'Donnell R, Patterson RE, Sigman SR, Smith AS, Baio KT, Kilgo PD, Guyton RA. Off‐pump and on‐pump coronary artery bypass grafting are associated with similar graft patency, myocardial ischemia, and freedom from reintervention: long‐term follow‐up of a randomized trial. Ann Thorac Surg. 2011;91:1836–1843.
    1. Kobayashi J, Tashiro T, Ochi M, Yaku H, Watanabe G, Satoh T, Tagusari O, Nakajima H, Kitamura S; Japanese Off‐Pump Coronary Revascularization Investigation (JOCRI) Study Group . Early outcome of a randomized comparison of off‐pump and on‐pump multiple arterial coronary revascularization. Circulation. 2005;112:I338–I343.
    1. Magee MJ, Alexander JH, Hafley G, Ferguson TB, Gibson CM, Harrington RA, Peterson ED, Califf RM, Kouchoukos NT, Herbert MA, Mack MJ; PREVENT IV Investigators . Coronary artery bypass graft failure after on‐pump and off‐pump coronary artery bypass: findings from PREVENT IV. Ann Thorac Surg. 2008;85:494–500.
    1. Zhang B, Zhou J, Li H, Liu Z, Chen A, Zhao Q. Comparison of graft patency between off‐pump and on‐pump coronary artery bypass grafting: an updated meta‐analysis. Ann Thorac Surg. 2014;97:1335–1341.
    1. Deppe A‐C, Arbash W, Kuhn EW, Slottosch I, Scherner M, Liakopoulos OJ, Choi Y‐H, Wahlers T. Current evidence of coronary artery bypass grafting off‐pump versus on‐pump: a systematic review with meta‐analysis of over 16,900 patients investigated in randomized controlled trials†. Eur J Cardiothorac Surg. 2016;49:1031–1041; discussion 1041.
    1. Takagi H, Watanabe T, Mizuno Y, Kawai N, Umemoto T; ALICE (All‐Literature Investigation of Cardiovascular Evidence) Group . A meta‐analysis of adjusted risk estimates for survival from observational studies of complete versus incomplete revascularization in patients with multivessel disease undergoing coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 2014;18:679–682.
    1. Magee MJ, Hebert E, Herbert MA, Prince SL, Dewey TM, Culica DV, Mack MJ. Fewer grafts performed in off‐pump bypass surgery: patient selection or incomplete revascularization? Ann Thorac Surg. 2009;87:1113–1118; discussion 1118.
    1. Lamy A, Devereaux PJ, Yusuf S. Five‐year outcomes after off‐pump or on‐pump coronary‐artery bypass grafting. N Engl J Med. 2017;376:894–895.
    1. Benedetto U, Caputo M, Patel NN, Fiorentino F, Bryan A, Angelini GD. Long‐term survival after off‐pump versus on‐pump coronary artery bypass graft surgery. Does completeness of revascularization play a role? Int J Cardiol. 2017;246:32–36.
    1. Benedetto U, Gaudino M, Di Franco A, Caputo M, Ohmes LB, Grau J, Glineur D, Girardi LN, Angelini GD. Incomplete revascularization and long‐term survival after coronary artery bypass surgery. Int J Cardiol. 2018;254:59–63.
    1. Caputo M, Reeves BC, Rajkaruna C, Awair H, Angelini GD. Incomplete revascularization during OPCAB surgery is associated with reduced mid‐term event‐free survival. Ann Thorac Surg. 2005;80:2141–2147.
    1. Glance LG, Dick AW, Osler TM, Mukamel DB. The relation between surgeon volume and outcome following off‐pump vs on‐pump coronary artery bypass graft surgery. Chest. 2005;128:829–837.
    1. Lapar DJ, Mery CM, Kozower BD, Kern JA, Kron IL, Stukenborg GJ, Ailawadi G. The effect of surgeon volume on mortality for off‐pump coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2012;143:854–863.
    1. Benedetto U, Altman DG, Gerry S, Gray A, Lees B, Flather M, Taggart DP; Arterial Revascularization Trial Investigators . Off‐pump versus on‐pump coronary artery bypass grafting: insights from the Arterial Revascularization Trial. J Thorac Cardiovasc Surg. 2018;155:1545–1553.e7.
    1. Bakaeen FG, Shroyer ALW, Gammie JS, Sabik JF, Cornwell LD, Coselli JS, Rosengart TK, O'Brien SM, Wallace A, Shahian DM, Grover FL, Puskas JD. Trends in use of off‐pump coronary artery bypass grafting: results from the Society of Thoracic Surgeons Adult Cardiac Surgery Database. J Thorac Cardiovasc Surg. 2014;148:856–864.
    1. Benedetto U, Lau C, Caputo M, Kim L, Feldman DN, Ohmes LB, Di Franco A, Soletti G, Angelini GD, Girardi LN, Gaudino M. Comparison of outcomes for off‐pump versus on‐pump coronary artery bypass grafting in low‐volume and high‐volume centers and by low‐volume and high‐volume surgeons. Am J Cardiol. 2018;121:552–557.
    1. Mukherjee D, Ahmed K, Baig K, Patel VM, Darzi A, Athanasiou T. Conversion and safety in off‐pump coronary artery bypass: a system failure that needs re‐emphasis. Ann Thorac Surg. 2011;91:630–639.
    1. Keeling B, Thourani V, Aliawadi G, Kim S, Cyr D, Badhwar V, Jacobs JP, Brennan JM, Meza J, Matsouaka R, Halkos ME. Conversion from off‐pump coronary artery bypass grafting to on‐pump coronary artery bypass grafting. Ann Thorac Surg. 2017;104:1267–1274.
    1. Mukherjee D, Ashrafian H, Kourliouros A, Ahmed K, Darzi A, Athanasiou T. Intra‐operative conversion is a cause of masked mortality in off‐pump coronary artery bypass: a meta‐analysis. Eur J Cardiothorac Surg. 2012;41:291–299.
    1. Stevens L‐M, Noiseux N, Avezum A, Ayapati DR, Chen X, Lucchese FA, Cacheda H, Parvathaneni S, Ou Y, Lamy A; CORONARY Investigators . Conversion after off‐pump coronary artery bypass grafting: the CORONARY trial experience. Eur J Cardiothorac Surg. 2017;51:539–546.
    1. Edgerton JR, Dewey TM, Magee MJ, Herbert MA, Prince SL, Jones KK, Mack MJ. Conversion in off‐pump coronary artery bypass grafting: an analysis of predictors and outcomes. Ann Thorac Surg. 2003;76:1138–1143.
    1. Reeves BC, Ascione R, Caputo M, Angelini GD. Morbidity and mortality following acute conversion from off‐pump to on‐pump coronary surgery. Eur J Cardiothorac Surg. 2006;29:941–947.
    1. Shiga T, Apfel CC, Wajima Z, Ohe Y. Influence of intraoperative conversion from off‐pump to on‐pump coronary artery bypass grafting on costs and quality of life: a cost‐effectiveness analysis. J Cardiothorac Vasc Anesth. 2007;21:793–799.
    1. Li Z, Amsterdam EA, Danielsen B, Hoegh H, Young JN, Armstrong EJ. Intraoperative conversion from off‐pump to on‐pump coronary artery bypass is associated with increased 30‐day hospital readmission. Ann Thorac Surg. 2014;98:16–22.
    1. Maroto Castellanos LC, Carnero M, Cobiella FJ, Alswies A, Ayaon A, Reguillo FJ, García M. Off‐pump to on‐pump emergency conversion: incidence, risk factors, and impact on short‐ and long‐term results. J Card Surg. 2015;30:735–745.
    1. Chowdhury R, White D, Kilgo P, Puskas JD, Thourani VH, Chen EP, Lattouf OM, Cooper WA, Myung RJ, Guyton RA, Halkos ME. Risk factors for conversion to cardiopulmonary bypass during off‐pump coronary artery bypass surgery. Ann Thorac Surg. 2012;93:1936–1941; discussion 1942.
    1. Mehaffey JH, Hawkins RB, Byler M, Charles EJ, Fonner C, Kron I, Quader M, Speir A, Rich J, Ailawadi G; Virginia Cardiac Services Quality Initiative . Cost of individual complications following coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2018;155:875–882.
    1. Arom KV, Emery RW, Flavin TF, Petersen RJ. Cost‐effectiveness of minimally invasive coronary artery bypass surgery. Ann Thorac Surg. 1999;68:1562–1566.
    1. Boyd WD, Desai ND, Del Rizzo DF, Novick RJ, McKenzie FN, Menkis AH. Off‐pump surgery decreases postoperative complications and resource utilization in the elderly. Ann Thorac Surg. 1999;68:1490–1493.
    1. Ascione R, Lloyd CT, Underwood MJ, Lotto AA, Pitsis AA, Angelini GD. Economic outcome of off‐pump coronary artery bypass surgery: a prospective randomized study. Ann Thorac Surg. 1999;68:2237–2242.
    1. Nathoe HM, van Dijk D, Jansen EWL, Suyker WJL, Diephuis JC, van Boven W‐J, de la Rivière AB, Borst C, Kalkman CJ, Grobbee DE, Buskens E, de Jaegere PPT; Octopus Study Group . A comparison of on‐pump and off‐pump coronary bypass surgery in low‐risk patients. N Engl J Med. 2003;348:394–402.
    1. Puskas JD, Williams WH, Mahoney EM, Huber PR, Block PC, Duke PG, Staples JR, Glas KE, Marshall JJ, Leimbach ME, McCall SA, Petersen RJ, Bailey DE, Weintraub WS, Guyton RA. Off‐pump vs conventional coronary artery bypass grafting: early and 1‐year graft patency, cost, and quality‐of‐life outcomes: a randomized trial. JAMA. 2004;291:1841–1849.
    1. Lamy A, Wang X, Farrokhyar F, Kent R. A cost comparison of off‐pump CABG versus on‐pump CABG at one‐year: the Canadian off‐pump CABG registry. Can J Cardiol. 2006;22:699–704.
    1. Chu D, Bakaeen FG, Dao TK, LeMaire SA, Coselli JS, Huh J. On‐pump versus off‐pump coronary artery bypass grafting in a cohort of 63,000 patients. Ann Thorac Surg. 2009;87:1820–1827.
    1. Houlind K, Kjeldsen BJ, Madsen SN, Rasmussen BS, Holme SJ, Pallesen PA, Mortensen PE, Fenger‐Grøn M, Beck SJ, Ehlers LH; DOORS Study Group . OPCAB surgery is cost‐effective for elderly patients. Scand Cardiovasc J. 2013;47:185–192.
    1. Lamy A, Tong W, Devereaux PJ, Gao P, Gafni A, Singh K, Taggart D, Straka Z, Akar AR, Piegas L, Ou Y, Yusuf S. The cost implications of off‐pump versus on‐pump coronary artery bypass graft surgery at one year. Ann Thorac Surg. 2014;98:1620–1625.
    1. Scott BH, Seifert FC, Grimson R, Glass PSA. Resource utilization in on‐ and off‐pump coronary artery surgery: factors influencing postoperative length of stay—an experience of 1,746 consecutive patients undergoing fast‐track cardiac anesthesia. J Cardiothorac Vasc Anesth. 2005;19:26–31.
    1. Wagner TH, Hattler B, Bishawi M, Baltz JH, Collins JF, Quin JA, Grover FL, Shroyer ALW; VA #517 Randomized On/Off Bypass (ROOBY) Study Group . On‐pump versus off‐pump coronary artery bypass surgery: cost‐effectiveness analysis alongside a multisite trial. Ann Thorac Surg. 2013;96:770–777.
    1. Shinjo D, Fushimi K. Preoperative factors affecting cost and length of stay for isolated off‐pump coronary artery bypass grafting: hierarchical linear model analysis. BMJ Open. 2015;5:e008750.
    1. Seco M, Edelman JJB, Van Boxtel B, Forrest P, Byrom MJ, Wilson MK, Fraser J, Bannon PG, Vallely MP. Neurologic injury and protection in adult cardiac and aortic surgery. J Cardiothorac Vasc Anesth. 2015;29:185–195.
    1. Zhao DF, Edelman JJ, Seco M, Bannon PG, Wilson MK, Byrom MJ, Thourani V, Lamy A, Taggart DP, Puskas JD, Vallely MP. Coronary artery bypass grafting with and without manipulation of the ascending aorta: a network meta‐analysis. J Am Coll Cardiol. 2017;69:924–936.
    1. Mohr FW, Morice M‐C, Kappetein AP, Feldman TE, Ståhle E, Colombo A, Mack MJ, Holmes DR, Morel M, Van Dyck N, Houle VM, Dawkins KD, Serruys PW. Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three‐vessel disease and left main coronary disease: 5‐year follow‐up of the randomised, clinical SYNTAX trial. Lancet. 2013;381:629–638.
    1. Meyerson J, Thelin S, Gordh T, Karlsten R. The incidence of chronic post‐sternotomy pain after cardiac surgery—a prospective study. Acta Anaesthesiol Scand. 2001;45:940–944.
    1. McGinn JT, Usman S, Lapierre H, Pothula VR, Mesana TG, Ruel M. Minimally invasive coronary artery bypass grafting: dual‐center experience in 450 consecutive patients. Circulation. 2009;120:S78–S84.
    1. Bonatti J, Schachner T, Bonaros N, Lehr EJ, Zimrin D, Griffith B. Robotically assisted totally endoscopic coronary bypass surgery. Circulation. 2011;124:236–244.
    1. Puskas JD, Halkos ME, DeRose JJ, Bagiella E, Miller MA, Overbey J, Bonatti J, Srinivas VS, Vesely M, Sutter F, Lynch J, Kirkwood K, Shapiro TA, Boudoulas KD, Crestanello J, Gehrig T, Smith P, Ragosta M, Hoff SJ, Zhao D, Gelijns AC, Szeto WY, Weisz G, Argenziano M, Vassiliades T, Liberman H, Matthai W, Ascheim DD. Hybrid coronary revascularization for the treatment of multivessel coronary artery disease: a multicenter observational study. J Am Coll Cardiol. 2016;68:356–365.
    1. Bonatti J, Vetrovec G, Riga C, Wazni O, Stadler P. Robotic technology in cardiovascular medicine. Nat Rev Cardiol. 2014;11:266–275.
    1. Lapierre H, Chan V, Sohmer B, Mesana TG, Ruel M. Minimally invasive coronary artery bypass grafting via a small thoracotomy versus off‐pump: a case‐matched study. Eur J Cardiothorac Surg. 2011;40:804–810.

Source: PubMed

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