Increased resting state functional connectivity in the fronto-parietal and default mode network in anorexia nervosa

Ilka Boehm, Daniel Geisler, Joseph A King, Franziska Ritschel, Maria Seidel, Yacila Deza Araujo, Juliane Petermann, Heidi Lohmeier, Jessika Weiss, Martin Walter, Veit Roessner, Stefan Ehrlich, Ilka Boehm, Daniel Geisler, Joseph A King, Franziska Ritschel, Maria Seidel, Yacila Deza Araujo, Juliane Petermann, Heidi Lohmeier, Jessika Weiss, Martin Walter, Veit Roessner, Stefan Ehrlich

Abstract

The etiology of anorexia nervosa (AN) is poorly understood. Results from functional brain imaging studies investigating the neural profile of AN using cognitive and emotional task paradigms are difficult to reconcile. Task-related imaging studies often require a high level of compliance and can only partially explore the distributed nature and complexity of brain function. In this study, resting state functional connectivity imaging was used to investigate well-characterized brain networks potentially relevant to understand the neural mechanisms underlying the symptomatology and etiology of AN. Resting state functional magnetic resonance imaging data was obtained from 35 unmedicated female acute AN patients and 35 closely matched healthy controls female participants (HC) and decomposed using spatial group independent component analyses (ICA). Using validated templates, we identified components covering the fronto-parietal "control" network, the default mode network (DMN), the salience network, the visual and the sensory-motor network. Group comparison revealed an increased functional connectivity between the angular gyrus and the other parts of the fronto-parietal network in patients with AN in comparison to HC. Connectivity of the angular gyrus was positively associated with self-reported persistence in HC. In the DMN, AN patients also showed an increased functional connectivity strength in the anterior insula in comparison to HC. Anterior insula connectivity was associated with self-reported problems with interoceptive awareness. This study, with one of the largest sample to date, shows that acute AN is associated with abnormal brain connectivity in two major resting state networks (RSN). The finding of an increased functional connectivity in the fronto-parietal network adds novel support for the notion of AN as a disorder of excessive cognitive control, whereas the elevated functional connectivity of the anterior insula with the DMN may reflect the high levels of self- and body-focused ruminations when AN patients are at rest.

Keywords: anorexia nervosa; cognitive control; default mode network; fMRI; fronto-parietal network; insula; interoceptive awareness; resting state connectivity.

Figures

Figure 1
Figure 1
Spatial maps of 10 independent components of interest grouped by network: DMN, somato-sensory, visual, fronto-parietal and salience network. Spatial maps are plotted as t-statistics thresholded at p = 0.05 (FWE).
Figure 2
Figure 2
Differences between patients with acute anorexia nervosa and healthy controls (A) in component 18, representing the frontal-parietal network and (B) in component 24, representing the default-mode network (for illustrative purposes shown at p = 0.001 uncorrected). Color bar represents t-values.

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