Correlation of Linezolid Hair Concentrations with Plasma Exposure in Patients with Drug-Resistant Tuberculosis

Sean Wasserman, Shu Huo, Karina Ky, Ysabella Noelle Malig, Ali Esmail, Keertan Dheda, Peter Bacchetti, Roy Gerona, Gary Maartens, Monica Gandhi, John Metcalfe, Sean Wasserman, Shu Huo, Karina Ky, Ysabella Noelle Malig, Ali Esmail, Keertan Dheda, Peter Bacchetti, Roy Gerona, Gary Maartens, Monica Gandhi, John Metcalfe

No abstract available

Keywords: MDR-TB; hair drug concentrations; linezolid.

Figures

FIG 1

Scatter plot of linezolid (LZD) plasma AUCs and geometric mean hair concentrations. Each point represents a linezolid AUC value and a geometric mean hair concentration for an individual participant. Solid line represents the linear regression line. Labeled points are participants with undetectable plasma linezolid predose concentrations; patient N2026 had poor treatment adherence.