Rhinosinusitis: Establishing definitions for clinical research and patient care

Eli O Meltzer, Daniel L Hamilos, James A Hadley, Donald C Lanza, Bradley F Marple, Richard A Nicklas, Claus Bachert, James Baraniuk, Fuad M Baroody, Michael S Benninger, Itzhak Brook, Badrul A Chowdhury, Howard M Druce, Stephen Durham, Berrylin Ferguson, Jack M Gwaltney Jr, Michael Kaliner, David W Kennedy, Valerie Lund, Robert Naclerio, Ruby Pawankar, Jay F Piccirillo, Patricia Rohane, Ronald Simon, Raymond G Slavin, Alkis Togias, Ellen R Wald, S James Zinreich, American Academy of Allergy, Asthma and Immunology, American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American College of Allergy, Asthma and Immunology, American Rhinologic Society, Eli O Meltzer, Daniel L Hamilos, James A Hadley, Donald C Lanza, Bradley F Marple, Richard A Nicklas, Claus Bachert, James Baraniuk, Fuad M Baroody, Michael S Benninger, Itzhak Brook, Badrul A Chowdhury, Howard M Druce, Stephen Durham, Berrylin Ferguson, Jack M Gwaltney Jr, Michael Kaliner, David W Kennedy, Valerie Lund, Robert Naclerio, Ruby Pawankar, Jay F Piccirillo, Patricia Rohane, Ronald Simon, Raymond G Slavin, Alkis Togias, Ellen R Wald, S James Zinreich, American Academy of Allergy, Asthma and Immunology, American Academy of Otolaryngic Allergy, American Academy of Otolaryngology-Head and Neck Surgery, American College of Allergy, Asthma and Immunology, American Rhinologic Society

Abstract

Background: There is a need for more research on all forms of rhinosinusitis. Progress in this area has been hampered by a lack of consensus definitions and the limited number of published clinical trials.

Objectives: To develop consensus definitions for rhinosinusitis and outline strategies useful in clinical trials.

Study design: Five national societies, The American Academy of Allergy, Asthma and Immunology; The American Academy of Otolaryngic Allergy; The American Academy of Otolaryngology Head and Neck Surgery; The American College of Allergy, Asthma and Immunology; and the American Rhinologic Society formed an expert panel from multiple disciplines. Over two days, the panel developed definitions for rhinosinusitis and outlined strategies for design of clinical trials.

Results: Committee members agreed to adopt the term “rhinosinusitis” and reached consensus on definitions and strategies for clinical research on acute presumed bacterial rhinosinusitis, chronic rhinosinusitis without polyposis, chronic rhinosinusitis with polyposis, and classic allergic fungal rhinosinusitis. Symptom and objective criteria, measures for monitoring research progress, and use of symptom scoring tools, quality-of-life instruments, radiologic studies, and rhinoscopic assessment were outlined for each condition.

Conclusions: The recommendations from this conference should improve accuracy of clinical diagnosis and serve as a starting point for design of rhinosinusitis clinical trials.

Figures

Fig 1
Fig 1
Sinus CT scan of a patient with viral rhinosinusitis showing abnormalities of the maxillary and ethmoid sinuses. Reprinted with permission from Arch Otolaryngol Head Neck Surg 1994;120:144. Copyrighted © 1994, American Medical Association. All Rights reserved.
Fig 2
Fig 2
Coronal CT scan of the maxillary sinus of an adult with a common cold. A, Fourth day of illness showing multiple bubbles in the sinus cavity (white arrows), occlusion of the infundibulum (black arrowhead), and homogeneous abnormality along the medial wall and floor of the sinus cavity (black arrow). B, Seventh day of the illness showing occlusion of the infundibulum (black arrowhead) and homogenous abnormaility of the lower two thirds of the sinus cavity (black arrow). Few bubbles are still present in this material, but most of those present earlier have burst (white arrow). Reprinted with permission from Gwaltney JM, Jr, Hendley JO, Phillips CD, et al. Nose blowing propels nasal fluid into the paranasal sinuses. Clin Infect Dis 2000;30(2):387–92. Published by The University of Chicago Press. © 2000 by the Infectious Diseases Society of America.
Fig 3
Fig 3
Intranasal pressure time histories for a representative nose blow, coughing bout, and sneeze shown on the same scale for comparison (dashed line, nose blow; solid line, coughing bout; dotted line, sneeze). Reprinted with permission from Gwaltney JM, Jr, Hendley JO, Phillips CD, et al. Nose blowing propels nasal fluid into the paranasal sinuses. Clin Infect Dis 2000;30(2):387–92. Published by The University of Chicago Press. © 2000 by the Infectious Diseases Society of America.
Fig 4
Fig 4
Sinus CT scan of an adult after instillation of contrast medium into the nasopharynx, followed by nose blowing. A, Contrast in an anterior ethmoid sinus cell (short arrow) and in the floor of the nasal cavities (long arrow). B, Contrast in the infundibulum bilaterally (short arrows) and in the maxillary sinus outlining a bubble (long arrows). C, Contrast in the posterior ethmoid sinus (arrow). D, Contrast in the sphenoid sinus outlining a bubble (arrow). Reprinted with permission from Gwaltney JM, Jr, Hendley JO, Phillips CD, et al. Nose blowing propels nasal fluid into the paranasal sinuses. Clin Infect Dis 2000;30(2):387–92. Published by The University of Chicago Press. © 2000 by the Infectious Diseases Society of America.
Fig 5
Fig 5
Soft tissue algorithm CT scan showing findings typical of AFRS. Note the heterogenous appearance within involved paranasal sinuses.
Fig 6
Fig 6
Sinus pressure thresholds (mean ± 95% CI) decreased from the healthy control (non-chronic fatigue syndrome/no rhinosinusitis) to chronic fatigue syndrome/CRS group. Significant differences were found from non-chronic fatigue syndrome/no rhinosinusitis (*P < 0.05, **P < 0.001, ***P < 0.00001, and ****P < 0.0000001), chronic fatigue syndrome/CRS (#P < 0.01, ##P < 0.0001), and chronic fatigue syndrome/no rhinosinusitis (@.07 < P < 0.05, @@P < 0.02). Sinus thresholds were significantly reduced in both subjects with chronic fatigue syndrome and subjects without chronic fatigue syndrome with acute rhinosinusitis and CRS compared with the non-chronic fatigue syndrome/no rhinosinusitis control group. CFS, Chronic fatigue syndrome; sinusitis, rhinosinusitis.
Fig 7
Fig 7
Two distinct histologic subsets of CRS. Glandular hypertrophy-hyperplasia is noted in May class III, with an increase in the percentage of the mucosal area occupied by mucous glands. In contrast, visually observed and histologic polypoid degeneration occurs in an exclusive and nonoverlapping group. Massive polyposis is found in pansinusitis (May class IV).
Fig 8
Fig 8
Proposed subclassification of CRS.

References

    1. Post J.C. Direct evidence of bacterial biofilms in otitis media. Laryngoscope. 2001;111:2083–2094.
    1. Khalid A.N., Hunt J., Perloff J.R., Kennedy D.W. The role of bone in chronic rhinosinusitis. Laryngoscope. 2002;112:1951–1957.
    1. Kennedy D.W., Senior B.A., Gannon F.H., Montone K.T., Hwang P., Lanza D.C. Histology and histomorphometry of ethmoid bone in chronic rhinosinusitis. Laryngoscope. 1998;108:502–507.
    1. Perloff J.R., Gannon F.H., Bolger W.E., Montone K.T., Orlandi R., Kennedy D.W. Bone involvement in sinusitis: an apparent pathway for the spread of disease. Laryngoscope. 2000;110:2095–2099.
    1. Hofer M.F., Harbeck R.J., Schlievert P.M., Leung D.Y. Staphylococcal toxins augment specific IgE responses by atopic patients exposed to allergen. J Invest Dermatol. 1999;112:171–176.
    1. Jabara H.H., Geha R.S. The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching. Int Immunol. 1996;8:1503–1510.
    1. Vennewald I., Henker M., Klemm E., Seebacher Fungal colonization of the paranasal sinuses. Mycosis. 1999;42:33–36.
    1. Ponikau J.U., Sherris D.A., Kern E.B. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc. 1999;74:877–884.
    1. Catten M., Murr A., Goldstein J., Mhatre A., Lalwani A. Detection of fungi in the nasal mucosal using polymerase chain reaction. Laryngoscope. 2001;111:399–403.
    1. International Rhinosinusitis Advisory Board Infectious rhinosinusitis in adults: classification, etiology and management. Ear Nose Throat J. 1997;76:5–22.
    1. Medicode. ICD-9-CM Expert for Hospitals. 6th ed. Ingenix-St Anthony’s Press; 2003. p. 137–l9.
    1. Lanza D.C., Kennedy D.W. Adult rhinosinusitis defined. Otolaryngol Head Neck Surg. 1997;117(suppl):S1–S7.
    1. Bachert C., Gevaert P., Holtappels G., Johansson S.G., van Cauwenberge P. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol. 2001;107:607–614.
    1. Bone R.C., Balk R.A., Cerra F.B., The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992;101:1644–1655.
    1. Chensue S., Ward P. Inflammation. In: Damjanov I., Linder J., editors. Anderson’s pathology. 10th ed. Mosby; St Louis: 1996.
    1. Collins T. Acute and chronic inflammation. In: Cotran R., Kumar V., Collins T., editors. Robbins’ pathologic basis of disease. W. B. Saunders; Philadelphia: 1999.
    1. Szekanecz Z., Koch A. Inflammation: cells, cytokines, and other mediators. In: Humes H., editor. Kelley’s textbook of internal medicine. 4th edition. Lippincott Williams & Wilkins; Philadelphia: 2000.
    1. Gwaltney J. Historical eras of the common cold. In: Sande M., Root T., editors. Contemporary issues in infectious disease. Churchill Livingstone; New York: 1993. pp. 1–13.
    1. Gwaltney J., Heinz B. Rhinovirus. In: Richman D., Whitley R., Hayden F., editors. Clinical virology. 2nd ed. ASM Press; Portland (OR): 2002. pp. 995–1018.
    1. Hendley J.O., Gwaltney J.M., Jr. Mechanisms of transmission of rhinovirus infections. Epidemiol Rev. 1988;10:243–258.
    1. Winther B., Gwaltney J.M., Jr, Mygind N., Turner R.B., Hendley J.O. Sites of rhinovirus recovery after point inoculation of the upper airway. JAMA. 1986;256:1763–1767.
    1. Winther B., Innes D.J. The human adenoid. A morphologic study. Arch Otolaryngol Head Neck Surg. 1994;120:144–149.
    1. Winther B., Greve J.M., Gwaltney J.M., Jr Surface expression of intercellular adhesion molecule 1 on epithelial cells in the human adenoid. J Infect Dis. 1997;176:523–525.
    1. Gwaltney J.M., Jr, Hayden F.G. Psychological stress and the common cold. N Engl J Med. 1992;326:644–646.
    1. Harris J.M., 2nd, Gwaltney J.M., Jr. Incubation periods of experimental rhinovirus infection and illness. Clin Infect Dis. 1996;23:1287–1290.
    1. Gwaltney J.M., Jr, Phillips C.D., Miller R.D., Riker D.K. Computed tomographic study of the common cold. N Engl J Med. 1994;330:25–30.
    1. Puhakka T., Makela M.J., Alanen A. Sinusitis in the common cold. J Allergy Clin Immunol. 1998;102:403–408.
    1. Kristo A., Uhari M., Luotonen J. Paranasal sinus findings in children during respiratory infection evaluated with magnetic resonance imaging. Pediatrics. 2003;111:e586–e589.
    1. Mogensen C., Tos M. Quantitative histology of the maxillary sinus. Rhinology. 1977;15:129–140.
    1. Mogensen C., Tos M. Quantitative histology of the normal sphenoidal sinus. Rhinology. 1978;16:203–213.
    1. Gwaltney J.M., Jr, Hendley J.O., Phillips C.D., Bass C.R., Mygind N., Winther B. Nose blowing propels nasal fluid into the paranasal sinuses. Clin Infect Dis. 2000;30:387–391.
    1. Gwaltney J.M., Jr. Acute community-acquired sinusitis. Clin Infect Dis. 1996;23:1209–1225.
    1. Gwaltney J.M., Jr, Wiesinger B.A., Patrie J.T. Acute community-acquired bacterial sinusitis: the value of antimicrobial treatment and the natural history. Clin Infect Dis. 2004;38:227–233.
    1. Arruda E., Boyle T.R., Winther B., Pevear D.C., Gwaltney J.M., Jr, Hayden F.G. Localization of human rhinovirus replication in the upper respiratory tract by in situ hybridization. J Infect Dis. 1995;171:1329–1333.
    1. Evans F.O., Jr, Sydnor J.B., Moore W.E. Sinusitis of the maxillary antrum. N Engl J Med. 1975;293:735–739.
    1. Wald E.R., Milmoe G.J., Bowen A., Ledesma-Medina J., Salamon N., Bluestone C.D. Acute maxillary sinusitis in children. N Engl J Med. 1981;304:749–754.
    1. Wald E.R., Reilly J.S., Casselbrant M. Treatment of acute maxillary sinusitis in childhood: a comparative study of amoxicillin and cefaclor. J Pediatr. 1984;104:297–302.
    1. Wald E.R., Byers C., Guerra N., Casselbrant M., Beste D. Subacute sinusitis in children. J Pediatr. 1989;115:28–32.
    1. Brook I. Bacteriologic features of chronic sinusitis in children. JAMA. 1981;246:967–969.
    1. Brook I., Yocum P., Shah K. Aerobic and anaerobic bacteriology of concurrent chronic otitis media with effusion and chronic sinusitis in children. Arch Otolaryngol Head Neck Surg. 2000;126:174–176.
    1. Otten F.W., Grote J.J. Treatment of chronic maxillary sinusitis in children. Int J Pediatr Otorhinolaryngol. 1988;15:269–278.
    1. Otten F.W. Conservative treatment of chronic maxillary sinusitis in children. Long-term follow-up. Acta Otorhinolaryngol Belg. 1997;51:173–175.
    1. Orobello P.W., Jr, Park R.I., Belcher L.J. Microbiology of chronic sinusitis in children. Arch Otolaryngol Head Neck Surg. 1991;117:980–983.
    1. Don D.M., Yellon R.F., Casselbrant M.L., Bluestone C.D. Efficacy of a stepwise protocol that includes intravenous antibiotic therapy for the management of chronic sinusitis in children and adolescents. Arch Otolaryngol Head Neck Surg. 2001;127:1093–1098.
    1. Muntz H.R., Lusk R.P. Bacteriology of the ethmoid bullae in children with chronic sinusitis. Arch Otolaryngol Head Neck Surg. 1991;117:179–181.
    1. Tinkelman D.G., Silk H.J. Clinical and bacteriologic features of chronic sinusitis in children. Am J Dis Child. 1989;143:938–941.
    1. Slack C.L., Dahn K.A., Abzug M.J., Chan K.H. Antibiotic-resistant bacteria in pediatric chronic sinusitis. Pediatr Infect Dis J. 2001;20:247–250.
    1. Felmingham D., Washington J. Trends in the antimicrobial susceptibility of bacterial respiratory tract pathogens—findings of the Alexander Project 1992–1996. J Chemother. 1999;11(suppl 1):5–21.
    1. Pfaller M.A., Jones R.N., Doern G.V., Kugler K. Bacterial pathogens isolated from patients with bloodstream infection: frequencies of occurrence and antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (United States and Canada, 1997) Antimicrob Agents Chemother. 1998;42:1762–1770.
    1. Bach A., Boehrer H., Schmidt H., Geiss H.K. Nosocomial sinusitis in ventilated patients. Nasotracheal versus orotracheal intubation. Anaesthesia. 1992;47:335–339.
    1. Mevio E., Benazzo M., Quaglieri S., Mencherini S. Sinus infection in intensive care patients. Rhinology. 1996;34:232–236.
    1. O’Reilly M.J., Reddick E.J., Black W. Sepsis from sinusitis in nasotracheally intubated patients. A diagnostic dilemma. Am J Surg. 1984;147:601–604.
    1. Arens J.F., LeJeune F.E., Jr, Webre D.R. Maxillary sinusitis, a complication of nasotracheal intubation. Anesthesiology. 1974;40:415–416.
    1. Caplan E.S., Hoyt N.J. Nosocomial sinusitis. JAMA. 1982;247:639–641.
    1. Kronberg F.G., Goodwin W.J., Jr. Sinusitis in intensive care unit patients. Laryngoscope. 1985;95:936–938.
    1. Miner J.D., Elliott C.L., Johnson C.W., McSoley T., Spahn J.G., Spahn T. Nosocomial sinusitis. Indiana Med. 1988;81:684–686.
    1. Doyle P.W., Woodham J.D. Evaluation of the microbiology of chronic ethmoid sinusitis. J Clin Microbiol. 1991;29:2396–2400.
    1. Hoyt W.H., 3rd Bacterial patterns found in surgery patients with chronic sinusitis. J Am Osteopath Assoc. 1992;92:209–212.
    1. Hsu J., Lanza D.C., Kennedy D.W. Antimicrobial resistance in bacterial chronic sinusitis. Am J Rhinol. 1998;12:243–248.
    1. Biel M.A., Brown C.A., Levinson R.M. Evaluation of the microbiology of chronic maxillary sinusitis. Ann Otol Rhinol Laryngol. 1998;107:942–945.
    1. Brook I., Frazier E.H. Correlation between microbiology and previous sinus surgery in patients with chronic maxillary sinusitis. Ann Otol Rhinol Laryngol. 2001;110:148–151.
    1. Jiang R.S., Lin J.F., Hsu C.Y. Correlation between bacteriology of the middle meatus and ethmoid sinus in chronic sinusitis. J Laryngol Otol. 2002;116:443–446.
    1. Finegold S.M., Flynn M.J., Rose F.V. Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults. Clin Infect Dis. 2002;35:428–433.
    1. Gordts F., Halewyck S., Pierard D., Kaufman L., Clement P.A. Microbiology of the middle meatus: a comparison between normal adults and children. J Laryngol Otol. 2000;114:184–188.
    1. Nadel D.M., Lanza D.C., Kennedy D.W. Endoscopically guided cultures in chronic sinusitis. Am J Rhinol. 1998;12:233–241.
    1. Frederick J., Braude A. Anaerobic infections of the paranasal sinuses. N Engl J Med. 1974;290:135–137.
    1. Carenfelt C., Lundberg C., Nord C.E., Wretlind B. Bacteriology of maxillary sinusitis in relation to quality of the retained secretion. Acta Otolaryngol. 1978;86:298–302.
    1. Brook I. Bacteriology of chronic maxillary sinusitis in adults. Ann Otol Rhinol Laryngol. 1989;98:426–428.
    1. Mustafa E., Tahsin A., Mustafa Ö., Nedret K. Bacteriology of antrum in adults with chronic maxillary sinusitis. Laryngoscope. 1994;104:321–324.
    1. Nord C.E. The role of anaerobic bacteria in recurrent episodes of sinusitis and tonsillitis. Clin Infect Dis. 1995;20:1512–1524.
    1. Klossek J.M., Dubreuil L., Richet H., Richet B., Beutter P. Bacteriology of chronic purulent secretions in chronic rhinosinusitis. J Laryngol Otol. 1998;112:1162–1166.
    1. Van Cauwenberge P.B., Ingels K.J., Bachert C., Wang D.Y. Microbiology of chronic sinusitis. Acta Otorhinolaryngol Belg. 1997;51:239–246.
    1. Wald E.R. Chronic sinusitis in children. J Pediatr. 1995;127:339–347.
    1. Stringer S., Ryan M.W. Chronic invasive fungal rhinosinusitis. Otolaryngol Clin North Am. 2000;33:375–387.
    1. Schell W.A. Unusual fungal pathogens in fungal rhinosinusitis. Otolaryngol Clin North Am. 2000;33:367–373.
    1. Miloshev B., Davidson C.M., Gentles J.C., Sandison A.T. Aspergilloma of paranasal sinuses and orbit in Northern Sudanese. Lancet. 1966;1:746–747.
    1. Marple B.F., Mabry R.L. Allergic fungal sinusitis: learning from our failures. Am J Rhinol. 2000;14:223–226.
    1. Horst M., Hejjaoui A., Horst V., Michel F.B., Bousquet J. Double-blind, placebo-controlled rush immunotherapy with a standardized Alternaria extract. J Allergy Clin Immunol. 1990;85:460–472.
    1. Downs S., Mitkakis T., Marks G. Clinical importance of Alternaria exposure in children. Am J Respir Crit Care Med. 2001;164:455–459.
    1. Manning S.C., Vuitch F., Weinberg A.G., Brown O.E. Allergic aspergillosis: a newly recognized form of sinusitis in the pediatric population. Laryngoscope. 1989;99:681–685.
    1. Marple B.F., Gibbs S.R., Newcomer M.T., Mabry R.L. Allergic fungal sinusitis-induced visual loss. Am J Rhinol. 1999;13:191–195.
    1. Manning S.C., Schaefer S.D., Close L.G., Vuitch F. Culture-positive allergic fungal sinusitis. Arch Otolaryngol Head Neck Surg. 1991;117:174–178.
    1. Marple B. Allergic fungal sinusitis. Curr Opin Otolaryngol. 1999;7:383–387.
    1. Manning S.C., Holman M. Further evidence for allergic pathophysiology in allergic fungal sinusitis. Laryngoscope. 1998;108:1485–1496.
    1. Mukherji S.K., Figueroa R.E., Ginsberg L.E. Allergic fungal sinusitis: CT findings. Radiology. 1998;207:417–422.
    1. Nussenbaum B., Marple B.F., Schwade N.D. Characteristics of bony erosion in allergic fungal rhinosinusitis. Otolaryngol Head Neck Surg. 2001;124:150–154.
    1. Zinreich S.J., Kennedy D.W., Malat J. Fungal sinusitis: diagnosis with CT and MR imaging. Radiology. 1988;169:439–444.
    1. Manning S.C., Merkel M., Kriesel K., Vuitch F., Marple B. Computed tomography and magnetic resonance diagnosis of allergic fungal sinusitis. Laryngoscope. 1997;107:170–176.
    1. Mabry R.L., Manning S. Radioallergosorbent microscreen and total immunoglobulin E in allergic fungal sinusitis. Otolaryngol Head Neck Surg. 1995;113:721–723.
    1. Manning S.C., Mabry R.L., Schaefer S.D., Close L.G. Evidence of IgE-mediated hypersensitivity in allergic fungal sinusitis. Laryngoscope. 1993;103:717–721.
    1. Chrzanowski R.R., Rupp N.T., Kuhn F.A., Phillips A.E., Dolen W.K. Allergenic fungi in allergic fungal sinusitis. Ann Allergy Asthma Immunol. 1997;79:431–435.
    1. Schubert M.S., Goetz D.W. Evaluation and treatment of allergic fungal sinusitis. I. Demographics and diagnosis. J Allergy Clin Immunol. 1998;102:387–394.
    1. Marple B.F., Mabry R.L. Comprehensive management of allergic fungal sinusitis. Am J Rhinol. 1998;12:263–268.
    1. Corey J.P. Allergic fungal sinusitis. Otolaryngol Clin North Am. 1992;25:225–230.
    1. Schnadig V.J., Rassekh C.H., Gourley W.K. Allergic fungal sinusitis. A report of two cases with diagnosis by intraoperative aspiration cytology. Acta Cytol. 1999;43:268–272.
    1. Torres C., Ro J.Y., el-Naggar A.K., Sim S.J., Weber R.S., Ayala A.G. Allergic fungal sinusitis: a clinicopathologic study of 16 cases. Hum Pathol. 1996;27:793–799.
    1. Miller J., Johnston A., Lamb D. Allergic aspergillosis of the maxillary sinuses. Proc Scott Thorac Soc. 1981;36:710–715.
    1. Lamb D., Miller J., Johnston A. Allergic aspergillosis of the paranasal sinuses. J Pathol. 1982;137:56.
    1. Katzenstein A.L., Sale S.R., Greenberger P.A. Allergic Aspergillus sinusitis: a newly recognized form of sinusitis. J Allergy Clin Immunol. 1983;72:89–93.
    1. Taylor M.J., Ponikau J.U., Sherris D.A. Detection of fungal organisms in eosinophilic mucin using a fluorescein-labeled chitin-specific binding protein. Otolaryngol Head Neck Surg. 2002;127:377–383.
    1. Loury M.C., Leopold D.A., Schaefer S.D. Allergic Aspergillus sinusitis. Arch Otolaryngol Head Neck Surg. 1993;119:1042–1043.
    1. Bent J.P., 3rd, Kuhn F.A. Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg. 1994;111:580–588.
    1. Ponikau J.U., Sherris D.A., Kita H., Kern E.B. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2002;110:862–866.
    1. Kita H. Presented at: 57th AAAAI Annual Meeting; March 2001; New Orleans (LA).
    1. Berrettini S., Carabelli A., Sellari-Franceschini S. Perennial allergic rhinitis and chronic sinusitis: correlation with rhinologic risk factors. Allergy. 1999;54:242–248.
    1. Holzmann D., Willi U., Nadal D. Allergic rhinitis as a risk factor for orbital complication of acute rhinosinusitis in children. Am J Rhinol. 2001;15:387–390.
    1. Blair C., Nelson M., Thompson K. Allergic inflammation enhances bacterial sinusitis in mice. J Allergy Clin Immunol. 2001;108:424–429.
    1. Kennedy D.W., Wright E.D., Goldberg A.N. Objective and subjective outcomes in surgery for chronic sinusitis. Laryngoscope. 2000;110:29–31.
    1. Settipane G.A., Chafee F.H. Nasal polyps in asthma and rhinitis. A review of 6,037 patients. J Allergy Clin Immunol. 1977;59:17–21.
    1. Keith P.K., Conway M., Evans S. Nasal polyps: effects of seasonal allergen exposure. J Allergy Clin Immunol. 1994;93:567–574.
    1. Drake-Lee A.B., McLaughlan P. Clinical symptoms, free histamine and IgE in patients with nasal polyposis. Int Arch Allergy Appl Immunol. 1982;69:268–271.
    1. Bernstein J.M., Ballow M., Schlievert P.M., Rich G., Allen C., Dryja D. A superantigen hypothesis for the pathogenesis of chronic hyperplastic sinusitis with massive nasal polyposis. Am J Rhinol. 2003;17:321–326.
    1. Bachert C., van Cauwenberge P. Nasal polyposis and sinusitis. In: Adkinson N., Yunginger J., Busse W., Bochner B., Holgate S., Simons E., editors. Allergy: principles and practice. 6th ed. Mosby; St Louis: 2003.
    1. Demoly P., Crampette L., Mondain M., Enander I., Jones I., Bousquet J. Myeloperoxidase and interleukin-8 levels in chronic sinusitis. Clin Exp Allergy. 1997;27:672–675.
    1. Ghaffar O., Durham S., Al-Ghamdi K. Expression of IgE heavy chain transcripts in the sinus mucosa of atopic and nonatopic patients with chronic sinusitis. Am J Respir Cell Mol Biol. 1998;18:706–711.
    1. Rhyoo C., Sanders S.P., Leopold D.A., Proud D. Sinus mucosal IL-8 gene expression in chronic rhinosinusitis. J Allergy Clin Immunol. 1999;103:395–400.
    1. Nonoyama T., Harada T., Shinogi J., Yoshimura E., Sakakura Y. Immunohistochemical localization of cytokines and cell adhesion molecules in maxillary sinus mucosa in chronic sinusitis. Auris Nasus Larynx. 2000;27:51–58.
    1. Bachert C., Wagenmann M., Rudack C. The role of cytokines in infectious sinusitis and nasal polyposis. Allergy. 1998;53:2–13.
    1. Rudack C., Stoll W., Bachert C. Cytokines in nasal polyposis, acute and chronic sinusitis. Am J Rhinol. 1998;12:383–388.
    1. Bachert C., Wagenmann M., Hauser U., Rudack C. IL-5 synthesis is upregulated in human nasal polyp tissue. J Allergy Clin Immunol. 1997;99:837–842.
    1. Roben P.W., Salem A.N., Silverman G.J. VH3 family antibodies bind domain D of staphylococcal protein A. J Immunol. 1995;154:6437–6445.
    1. Bachert C., Gevaert P., van Cauwenberge P. Staphylococcus aureus enterotoxins: a key in airway disease? Allergy. 2002;57:480–487.
    1. Bachert C., Gevaert P., Howarth P., Holtappels G., van Cauwenberge P., Johansson S.G. IgE to Staphylococcus aureus enterotoxins in serum is related to severity of asthma. J Allergy Clin Immunol. 2003;111:1131–1132.
    1. Baraniuk J.N. Neurogenic mechanisms in rhinosinusitis. Curr Allergy Asthma Rep. 2001;1:252–261.
    1. Baraniuk J., Staevska M. Perennial nonallergic rhinitis. In: Lichtenstein L., Busse W., Geha R., editors. Current therapy in allergy immunology and rheumatology. 6th ed. Mosby; St Louis: 2003.
    1. Biedlingmaier J.F., Trifillis A. Comparison of CT scan and electron microscopic findings on endoscopically harvested middle turbinates. Otolaryngol Head Neck Surg. 1998;118:165–173.
    1. Barrow C. Hemisphere Publishing; Washington (DC): 1986. Toxicology of the nasal passages.
    1. Baraniuk J., Naranch K., Maibach H., Clauw D. Irritant rhinitis in allergic, nonallergic, control and chronic fatigue syndrome populations. J Chronic Fatigue Syndr. 2000;7:3–31.
    1. Baraniuk J., Naranch K., Maibach H., Clauw D. Tobacco sensitivity in chronic fatigue syndrome. J Chronic Fatigue Syndr. 2000;7:33–52.
    1. Baraniuk J.N., Ali M., Yuta A., Fang S.Y., Naranch K. Hypertonic saline nasal provocation stimulates nociceptive nerves, substance P release, and glandular mucous exocytosis in normal humans. Am J Respir Crit Care Med. 1999;160:655–662.
    1. Gunthorpe M.J., Benham C.D., Randall A., Davis J.B. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci. 2002;23:183–191.
    1. Naranch K., Park Y.J., Repka-Ramirez M.S., Velarde A., Clauw D., Baraniuk J.N. A tender sinus does not always mean rhinosinusitis. Otolaryngol Head Neck Surg. 2002;127:387–397.
    1. Sanico A.M., Koliatsos V.E., Stanisz A.M., Bienenstock J., Togias A. Neural hyperresponsiveness and nerve growth factor in allergic rhinitis. Int Arch Allergy Immunol. 1999;118:154–158.
    1. Stevenson D., Simon R. Sensitivity to aspirin and non-steroidal anti-inflammatory drugs. In: Middleton E., Reed C., Ellis E., Adkinson N., Yunginger J., Busse W., editors. Allergy: principles and practice. 6th ed. Mosby; St Louis: 2003.
    1. Bianco S., Petrini G. Aspirin induced tolerance in aspirin-asthma detected by a new challenge test. J Med Sci. 1977;5:129–136.
    1. Schmitz-Schumann V., Juhl E., Costabel U. Analgesic asthma-provocation challenge with acetylsalicylic acid. Atemw Lungenkrkh Jahrgang. 1985;10:479–485.
    1. Phillips G.D., Foord R., Holgate S.T. Inhaled lysine-aspirin as a bronchoprovocation procedure in aspirin-sensitive asthma: its repeatability, absence of a late-phase reaction, and the role of histamine. J Allergy Clin Immunol. 1989;84:232–241.
    1. Melillo G., Padovano A., Cocco G., Masi C. Dosimeter inhalation test with lysine acetylsalicylate for the detection of aspirin-induced asthma. Ann Allergy. 1993;71:61–65.
    1. Milewski M., Mastalerz L., Nizankowska E., Szczeklik A. Nasal provocation test with lysine-aspirin for diagnosis of aspirin-sensitive asthma. J Allergy Clin Immunol. 1998;101:581–586.
    1. Patriarca G., Nucera E., DiRienzo V., Schiavino D., Pellegrino S., Fais G. Nasal provocation test with lysine acetylsalicylate in aspirin-sensitive patients. Ann Allergy. 1991;67:60–62.
    1. Pawlowicz A., Williams W.R., Davies B.H. Inhalation and nasal challenge in the diagnosis of aspirin-induced asthma. Allergy. 1991;46:405–409.
    1. Szczeklik A., Serwonska M. Inhibition of idiosyncratic reactions to aspirin in asthmatic patients by clemastine. Thorax. 1979;34:654–657.
    1. Nizankowska E., Szczeklik A. Glucocorticosteroids attenuate aspirin-precipitated adverse reactions in aspirin-intolerant patients with asthma. Ann Allergy. 1989;63:159–162.
    1. Pauls J.D., Simon R.A., Daffern P.J., Stevenson D.D. Lack of effect of the 5-lipoxygenase inhibitor zileuton in blocking oral aspirin challenges in aspirin-sensitive asthmatics. Ann Allergy Asthma Immunol. 2000;85:40–45.
    1. Stevenson D.D., Simon R.A., Mathison D.A., Christiansen S.C. Montelukast is only partially effective in inhibiting aspirin responses in aspirin-sensitive asthmatics. Ann Allergy Asthma Immunol. 2000;85:477–482.
    1. Koufman J.A. Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear Nose Throat J. 2002;81:7–9.
    1. Koufman J.A., Belafsky P.C., Bach K.K., Daniel E., Postma G.N. Prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. Laryngoscope. 2002;112:1606–1609.
    1. Richter J.E. Extraesophageal presentations of gastroesophageal reflux disease: an overview. Am J Gastroenterol. 2000;95(suppl):S1–S3.
    1. Theodoropoulos D.S., Ledford D.K., Lockey R.F. Prevalence of upper respiratory symptoms in patients with symptomatic gastroesophageal reflux disease. Am J Respir Crit Care Med. 2001;164:72–76.
    1. Richter J.E. Extraesophageal presentations of gastroesophageal reflux disease. Semin Gastrointest Dis. 1997;8:75–89.
    1. Orlando R.C. The pathogenesis of gastroesophageal reflux disease: the relationship between epithelial defense, dysmotility, and acid exposure. Am J Gastroenterol. 1997;92(Suppl 4):3S–5S.
    1. Richter J.E., Bradley L.A., DeMeester T.R., Wu W.C. Normal 24-hr ambulatory esophageal pH values. Influence of study center, pH electrode, age, and gender. Dig Dis Sci. 1992;37:849–856.
    1. Belafsky P.C., Postma G.N., Amin M.R. Symptoms and findings of laryngopharyngeal reflux. Ear Nose Throat J. 2002;81(9 Suppl 2):10–13.
    1. Vaezi M.F., Schroeder P.L., Richter J.E. Reproducibility of proximal probe pH parameters in 24-hour ambulatory esophageal pH monitoring. Am J Gastroenterol. 1997;92:825–829.
    1. Phipps C.D., Wood W.E., Gibson W.S., Cochran W.J. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg. 2000;126:831–836.
    1. DiBaise J.K., Olusola B.F., Huerter J.V., Quigley E.M. Role of GERD in chronic resistant sinusitis: a prospective, open label, pilot trial. Am J Gastroenterol. 2002;97:843–850.
    1. Spector S.L., Bernstein I.L., Li J.T. Parameters for the diagnosis and management of sinusitis. J Allergy Clin Immunol. 1998;102(suppl):S107–S144.
    1. Bachert C., Verhaeghe B. Differential diagnosis of rhinosinusitis. Fam Prac Recert. 2002;24(suppl):S8–S13.
    1. Kaliner M.A., Osguthorpe J.D., Fireman P. Sinusitis: bench to bedside. Current findings, future directions. J Allergy Clin Immunol. 1997;99(suppl):S829–S848.
    1. Jones N.S. Current concepts in the management of paediatric rhinosinusitis. J Laryngol Otol. 1999;113:1–9.
    1. Desrosiers M., Frenkiel S., Hamid Q.A. Acute bacterial sinusitis in adults: management in the primary care setting. J Otolaryngol. 2002;31(suppl 2):2S–14S.
    1. Mucha S.M., Baroody F.M. Sinusitis update. Curr Opin Allergy Clin Immunol. 2003;3:33–38.
    1. Dykewicz M.S. 7. Rhinitis and sinusitis. J Allergy Clin Immunol. 2003;111(suppl):S520–S529.
    1. Malekzadeh S., Hamburger M.D., Whelan P.J., Biedlingmaier J.F., Baraniuk J.N. Density of middle turbinate subepithelial mucous glands in patients with chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2002;127:190–195.
    1. May M., Levine H., Schaitkin B. Results of surgery. In: Levine H., May M., editors. Rhinology and sinusology. Thieme Medical Publishing; New York: 1993. pp. 105–125.
    1. Berger G., Kattan A., Bernheim J., Ophir D. Polypoid mucosa with eosinophilia and glandular hyperplasia in chronic sinusitis: a histopathological and immunohistochemical study. Laryngoscope. 2002;112:738–745.
    1. Kramer M.F., Ostertag P., Pfrogner E., Rasp G. Nasal interleukin-5, immunoglobulin E, eosinophilic cationic protein, and soluble intercellular adhesion molecule-1 in chronic sinusitis, allergic rhinitis, and nasal polyposis. Laryngoscope. 2000;110:1056–1062.
    1. Eichel B.S. A proposal for a staging system for hyperplastic rhinosinusitis based on the presence or absence of intranasal polyposis. Ear Nose Throat J. 1999;78 268–52.
    1. Fang S.Y., Jin Y.T. Application of endoscopic sinus surgery to primary atrophic rhinitis? A clinical trial. Rhinology. 1998;36:122–127.
    1. Georgitis J.W., Matthews B.L., Stone B. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. Int Arch Allergy Immunol. 1995;106:416–421.
    1. Stierna P., Carlsoo B. Histopathological observations in chronic maxillary sinusitis. Acta Otolaryngol. 1990;110:450–458.
    1. Jankowski R., Bouchoua F., Coffinet L., Vignaud J.M. Clinical factors influencing the eosinophil infiltration of nasal polyps. Rhinology. 2002;40:173–178.
    1. Stoop A.E., van der Heijden H.A., Biewenga J., van der Baan S. Eosinophils in nasal polyps and nasal mucosa: an immunohistochemical study. J Allergy Clin Immunol. 1993;91:616–622.
    1. Kakoi H., Hiraide F. A histological study of formation and growth of nasal polyps. Acta Otolaryngol. 1987;103:137–144.
    1. Taylor M. Histochemical studies on nasal polypi. J Laryngol Otol. 1963;77:326–341.
    1. Mygind N., Dahl R., Bachert C. Nasal polyposis, eosinophil dominated inflammation, and allergy. Thorax. 2000;55(suppl 2):S79–S83.
    1. Bachert C., Gevaert P., Holtappels G., Cuvelier C., van Cauwenberge P. Nasal polyposis: from cytokines to growth. Am J Rhinol. 2000;14:279–290.
    1. Persson C. Mucosal exudation mechanisms. Allergy Clin Immunol News. 1991;5:142.
    1. Hamilos D.L., Leung D.Y., Wood R. Chronic hyperplastic sinusitis: association of tissue eosinophilia with mRNA expression of granulocyte-macrophage colony-stimulating factor and interleukin-3. J Allergy Clin Immunol. 1993;92:39–48.
    1. Hamilos D.L. Nasal polyps as immunoreactive tissue. Allergy Asthma Proc. 1996;17:293–296.
    1. Bucholtz G.A., Salzman S.A., Bersalona F.B. PCR analysis of nasal polyps, chronic sinusitis, and hypertrophied turbinates for DNA encoding bacterial 16S rRNA. Am J Rhinol. 2002;16:169–173.
    1. Hamilos D.L., Leung D.Y., Muro S. GRbeta expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone. J Allergy Clin Immunol. 2001;108:59–68.
    1. Seki H., Otsuka H., Pawankar R. Nippon Jibiinkoka Gakkai Kaiho. 1992;95:1012–1021. [Studies on the function of mast cells infiltrating in nasal polyps]
    1. Sanchez-Segura A., Brieva J.A., Rodriguez C. T lymphocytes that infiltrate nasal polyps have a specialized phenotype and produce a mixed TH1/TH2 pattern of cytokines. J Allergy Clin Immunol. 1998;102:953–960.
    1. Hamilos D.L., Leung D.Y., Huston D.P., Kamil A., Wood R., Hamid Q. GM-CSF, IL-5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP) Clin Exp Allergy. 1998;28:1145–1152.
    1. Hamilos D.L., Leung D.Y., Wood R. Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) is associated with endothelial VCAM-1 upregulation and expression of TNF-alpha. Am J Respir Cell Mol Biol. 1996;15:443–450.
    1. Jahnsen F.L., Haraldsen G., Aanesen J.P., Haye R., Brandtzaeg P. Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps. Am J Respir Cell Mol Biol. 1995;12:624–632.
    1. Beck L.A., Stellato C., Beall L.D. Detection of the chemokine RANTES and endothelial adhesion molecules in nasal polyps. J Allergy Clin Immunol. 1996;98:766–780.
    1. Nonaka M., Pawankar R., Saji F., Yagi T. Eotaxin synthesis by nasal polyp fibroblasts. Acta Otolaryngol. 1999;119:816–820.
    1. Pawankar R. Nasal polyposis: an update. Curr Opin Allergy Clin Immunol. 2003;3:1–6. editorial review.
    1. Wang Q.P., Escudier E., Roudot-Thoraval F., Abd-Al Samad I., Peynegre R., Coste A. Myofibroblast accumulation induced by transforming growth factor-beta is involved in the pathogenesis of nasal polyps. Laryngoscope. 1997;107:926–931.
    1. Molet S.M., Hamid Q.A., Hamilos D.L. IL-11 and IL-17 expression in nasal polyps: relationship to collagen deposition and suppression by intranasal fluticasone propionate. Laryngoscope. 2003;113:1803–1812.
    1. Coste A., Brugel L., Maitre B. Inflammatory cells as well as epithelial cells in nasal polyps express vascular endothelial growth factor. Eur Respir J. 2000;15:367–372.
    1. Xing Z., Jordana M., Braciak T., Ohtoshi T., Gauldie J. Lipopolysaccharide induces expression of granulocyte/macrophage colony-stimulating factor, interleukin-8, and interleukin-6 in human nasal, but not lung, fibroblasts: evidence for heterogeneity within the respiratory tract. Am J Respir Cell Mol Biol. 1993;9:255–263.
    1. Elovic A., Wong D.T., Weller P.F., Matossian K., Galli S.J. Expression of transforming growth factors-alpha and beta 1 messenger RNA and product by eosinophils in nasal polyps. J Allergy Clin Immunol. 1994;93:864–869.
    1. Chang C.H., Chai C.Y., Ho K.Y. Expression of transforming growth factor-beta 1 and alpha-smooth muscle actin of myofibroblast in the pathogenesis of nasal polyps. Kaohsiung J Med Sci. 2001;17:133–138.
    1. Pawankar R. Mast cells in rhinitis. In: Watanabe T., Timmerman H., Yanai K., editors. Histamine research in the new millennium. Elsevier Science; Amsterdam: 2001. pp. 369–374.
    1. Di Lorenzo G., Drago A., Esposito Pellitteri M. Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis. Int Arch Allergy Immunol. 2001;125:164–175.
    1. Kim Y.K., Uno M., Hamilos D.L. Immunolocalization of CD34 in nasal polyposis. Effect of topical corticosteroids. Am J Respir Cell Mol Biol. 1999;20:388–397.
    1. Simon H.U., Yousefi S., Schranz C., Schapowal A., Bachert C., Blaser K. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol. 1997;158:3902–3908.
    1. Hamilos D.L., Thawley S.E., Kramper M.A., Kamil A., Hamid Q.A. Effect of intranasal fluticasone on cellular infiltration, endothelial adhesion molecule expression, and proinflammatory cytokine mRNA in nasal polyp disease. J Allergy Clin Immunol. 1999;103:79–87.
    1. Minshall E.M., Cameron L., Lavigne F. Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Am J Respir Cell Mol Biol. 1997;17:683–690.
    1. Hamilos D.L., Leung D.Y., Wood R. Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol. 1995;96:537–544.
    1. Nonaka M., Pawankar R., Saji F., Yagi T. Distinct expression of RANTES and GM-CSF by lipopolysaccharide in human nasal fibroblasts but not in other airway fibroblasts. Int Arch Allergy Immunol. 1999;119:314–321.
    1. Gevaert P., Bachert C., Holtappels G. Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis. Allergy. 2003;58:371–379.
    1. Miller C.H., Pudiak D.R., Hatem F., Looney R.J. Accumulation of interferon gamma-producing TH1 helper T cells in nasal polyps. Otolaryngol Head Neck Surg. 1994;111:51–58.
    1. Wagenmann M., Gärtner-Ackerboom M., Helmig P. Increased production of typ-2 and type-1 cytokines in nasal polyps. J Allergy Clin Immunol. 2000;105(suppl):S210.
    1. Davidsson A., Danielsen A., Viale G. Positive identification in situ of mRNA expression of IL-6, and IL-12, and the chemotactic cytokine RANTES in patients with chronic sinusitis and polypoid disease. Clinical relevance and relation to allergy. Acta Otolaryngol. 1996;116:604–610.
    1. Adkins T.N., Goodgold H.M., Hendershott L., Slavin R.G. Does inhaled pollen enter the sinus cavities? Ann Allergy Asthma Immunol. 1998;81:181–184.
    1. Braunstahl G.J., Kleinjan A., Overbeek S.E., Prins J.B., Hoogsteden H.C., Fokkens W.J. Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients. Am J Respir Crit Care Med. 2000;161:2051–2057.
    1. Braunstahl G.J., Overbeek S.E., Kleinjan A., Prins J.B., Hoogsteden H.C., Fokkens W.J. Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways. J Allergy Clin Immunol. 2001;107:469–476.
    1. Braunstahl G.J., Overbeek S.E., Fokkens W.J. Segmental bronchoprovocation in allergic rhinitis patients affects mast cell and basophil numbers in nasal and bronchial mucosa. Am J Respir Crit Care Med. 2001;164:858–865.
    1. Baroody F., deTineo M., Haney L., Clark K., Blair C., Naclerio R.A. Influx of eosinophils into the maxillary sinus after nasal challenge with allergen. J Allergy Clin Immunol. 2000;105(suppl):S70. [abstract]
    1. Bachert C., van Zele T., Gevaert P., De Schrijver L., Van Cauwenberge P. Superantigens and nasal polyps. Curr Allergy Asthma Rep. 2003;3:523–531.
    1. Calenoff E., McMahan J.T., Herzon G.D., Kern R.C., Ghadge G.D., Hanson D.G. Bacterial allergy in nasal polyposis. A new method for quantifying specific IgE. Arch Otolaryngol Head Neck Surg. 1993;119:830–836.
    1. Holtzman M.J., Morton J.D., Shornick L.P. Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm. Physiol Rev. 2002;82:19–46.
    1. Sampath D., Castro M., Look D.C., Holtzman M.J. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J Clin Invest. 1999;103:1353–1361.
    1. Watelet J.B., Bachert C., Claeys C., Van Cauwenberge P. Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis. Allergy. 2004;59:54–60.
    1. Pawankar R., Watanabe S., Nonaka M. Differential expression of MMP-2 and 9 in the allergic nasal mucosa and nasal polyps. J Allergy Clin Immunol. 2004;113(2):S332. [abstract]
    1. Bhattacharyya N., Vyas D.K., Fechner F.P., Gliklich R.E., Metson R. Tissue eosinophilia in chronic sinusitis: quantification techniques. Arch Otolaryngol Head Neck Surg. 2001;127:1102–1105.
    1. Subramanian H.N., Schechtman K.B., Hamilos D.L. A retrospective analysis of treatment outcomes and time to relapse after intensive medical treatment for chronic sinusitis. Am J Rhinol. 2002;16:303–312.
    1. Ferguson B. Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope. 2000;110:799–813.
    1. Braun H., Stammberger H., Buzina W., Freudenschuss K., Lackner A., Beham A. Incidence and detection of fungi and eosinophilic granulocytes in chronic rhinosinusitis. Laryngorhinootologie. 2003;82:330–340.
    1. Ferguson B. Definitions of fungal rhinosinusitis. Otolaryngol Clin North Am. 2000;33:227–235.
    1. Lund V.J., Kennedy D.W. Quantification for staging sinusitis. The Staging and Therapy Group. Ann Otol Rhinol Laryngol Suppl. 1995;167:17–21.
    1. Shapiro G.G., Rachelefsky G.S. Introduction and definition of sinusitis. J Allergy Clin Immunol. 1992;90:417–418.
    1. Meltzer E.O., Orgel H.A., Backhaus J.W. Intranasal flunisolide spray as an adjunct to oral antibiotic therapy for sinusitis. J Allergy Clin Immunol. 1993;92:812–823.
    1. Lund V., Gwaltney J., Baquero F. Infectious rhinosinusitis in adults: classification, etiology and management. Ear Nose Throat J. 1997;76(suppl):S5–S22.
    1. Williams J.W., Jr, Simel D.L. Does this patient have sinusitis? Diagnosing acute sinusitis by history and physical examination. JAMA. 1993;270:1242–1246.
    1. Bhattacharyya N. The economic burden and symptom manifestations of chronic rhinosinusitis. Am J Rhinol. 2003;17:27–32.
    1. Levine H.L. Patients with headache and visual disturbance: a differentiation between migraine and sinonasal headache. Arch Otolaryngol Head Neck Surg. 2000;126:234–235.
    1. Spector S.L., Nicklas R.A., Chapman J.A. Symptom severity assessment of allergic rhinitis: part 1. Ann Allergy Asthma Immunol. 2003;91:105–114.
    1. Pemberton E. Technique for measuring the optimum rating scale for opinion measures. Sociol Soc Res. 1933;17:470–472.
    1. Miller G.A. The magical number seven plus or minus two: some limits on our capacity for processing information. Psychol Rev. 1956;63:81–97.
    1. Juniper E.F., Guyatt G.H., Andersson B., Ferrie P.J. Comparison of powder and aerosolized budesonide in perennial rhinitis: validation of rhinitis quality of life questionnaire. Ann Allergy. 1993;70:225–230.
    1. Roper W.L., Winkenwerder W., Hackbarth G.M., Krakauer H. Effectiveness in health care. An initiative to evaluate and improve medical practice. N Engl J Med. 1988;319:1197–1202.
    1. Piccirillo J.F. Outcomes research and otolaryngology. Otolaryngol Head Neck Surg. 1994;111:764–769.
    1. Clancy C.M., Eisenberg J.M. Outcomes research: measuring the end results of health care. Science. 1998;282:245–246.
    1. Gliklich R.E., Metson R. Techniques for outcomes research in chronic sinusitis. Laryngoscope. 1995;105:387–390.
    1. Feinstein A.R. Clinical biostatistics. XLI. Hard science, soft data, and the challenges of choosing clinical variables in research. Clin Pharmacol Ther. 1977;22:485–498.
    1. Cella D.F. Quality of life: concepts and definition. J Pain Symptom Manage. 1994;9:186–192.
    1. Covinsky K.E., Wu A.W., Landefeld C.S. Health status versus quality of life in older patients: does the distinction matter? Am J Med. 1999;106:435–440.
    1. Guyatt G.H. Making sense of quality-of-life data. Med Care. 2000;38:II175–II179.
    1. Gill T.M., Feinstein A.R. A critical appraisal of the quality of quality-of-life measurements. JAMA. 1994;272:619–626.
    1. Lara-Munoz C., Feinstein A.R. How should quality of life be measured? J Investig Med. 1999;47:17–24.
    1. Yueh B., Feinstein A.R. Abstruse comparisons: the problems of numerical contrasts of two groups. J Clin Epidemiol. 1999;52:13–18.
    1. Streiner D., Norman G. Oxford University Press; New York: 1995. Health Measurement Scales.
    1. Ware J., Snow K., Kosinski M., Gandek B. The Health Institute; Boston, MA: 1999. SF-36 Health Survey. Manual and Interpretation Guide.
    1. Lund V.J., Holmstrom M., Scadding G.K. Functional endoscopic sinus surgery in the management of chronic rhinosinusitis. An objective assessment. J Laryngol Otol. 1991;105:832–835.
    1. Piccirillo J., Edwards D., Haiduk A., Yonan C., Thawley S. Psychometric and clinimetric validity of the 31-item rhinosinusitis outcome measure (RSOM-31) Am J Rhinol. 1995;9:297–306.
    1. Piccirillo J.F., Merritt M.G., Jr, Richards M.L. Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20) Otolaryngol Head Neck Surg. 2002;126:41–47.
    1. Benninger M.S., Senior B.A. The development of the Rhinosinusitis Disability Index. Arch Otolaryngol Head Neck Surg. 1997;123:1175–1179.
    1. Ware J.E., Brook R., Davies-Avery A. The RAND Corporation; Santa Monica (CA): 1980. Conceptualization and measurement of health for adults in the Health Insurance Study. Volume I: Model of health and methodology.
    1. Gliklich R.E., Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg. 1995;113:104–109.
    1. Hwang P.H., Irwin S.B., Griest S.E., Caro J.E., Nesbit G.M. Radiologic correlates of symptom-based diagnostic criteria for chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2003;128:489–496.
    1. Gray L.P. Deviated nasal septum. Incidence and etiology. Ann Otol Rhinol Laryngol Suppl. 1978;87:3–20.
    1. Stankiewicz J.A., Chow J.M. Nasal endoscopy and the definition and diagnosis of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2002;126:623–627.
    1. Lanza D. Diagnosis of chronic rhinosinusitis. Ann Otol Rhinol Laryngol. 2004;113:10–14.
    1. Nadel D.M., Lanza D.C., Kennedy D.W. Endoscopically guided sinus cultures in normal subjects. Am J Rhinol. 1999;13:87–90.
    1. Stammberger H., Wolf G. Headaches and sinus disease: the endoscopic approach. Ann Otol Rhinol Laryngol Suppl. 1988;134:3–23.
    1. Gungor A., Baroody F.M., Naclerio R.M., White S.R., Corey J.P. Decreased neuropeptide release may play a role in the pathogenesis of nasal polyps. Otolaryngol Head Neck Surg. 1999;121:585–590.
    1. Fang S.Y., Shen C.L., Ohyama M. Presence of neuropeptides in human nasal polyps. Acta Otolaryngol. 1994;114:324–328.
    1. Vogan J.C., Bolger W.E., Keyes A.S. Endoscopically guided sinonasal cultures: a direct comparison with maxillary sinus aspirate cultures. Otolaryngol Head Neck Surg. 2000;122:370–373.
    1. Talbot G.H., Kennedy D.W., Scheld W.M., Granito K. Rigid nasal endoscopy versus sinus puncture and aspiration for microbiologic documentation of acute bacterial maxillary sinusitis. Clin Infect Dis. 2001;33:1668–1675.
    1. Araujo E., Palombini B.C., Cantarelli V., Pereira A., Mariante A. Microbiology of middle meatus in chronic rhinosinusitis. Am J Rhinol. 2003;17:9–15.
    1. Tantilipikorn P., Fritz M., Tanabodee J., Lanza D.C., Kennedy D.W. A comparison of endoscopic culture techniques for chronic rhinosinusitis. Am J Rhinol. 2002;16:255–260.
    1. American Academy of Pediatrics, Subcommittee on Management of Sinusitis and Committee on Quality Improvement Clinical practice guideline: management of sinusitis. Pediatrics. 2001;108:798–808.
    1. Gordts F., Abu Nasser I., Clement P.A., Pierard D., Kaufman L. Bacteriology of the middle meatus in children. Int J Pediatr Otorhinolaryngol. 1999;48:163–167.
    1. Klossek J.M., Dubreuil L., Richet H., Richet B., Sedallian A., Beutter P. Bacteriology of the adult middle meatus. J Laryngol Otol. 1996;110:847–849.
    1. Gold S.M., Tami T.A. Role of middle meatus aspiration culture in the diagnosis of chronic sinusitis. Laryngoscope. 1997;107:1586–1589.
    1. Winther B., Vicery C., Gross C., Hendley O. Microbiology of the maxillary sinus in adults with chronic sinus disease. Am J Rhinol. 1996;10:347–350.
    1. Kountakis S.E., Skoulas I.G. Middle meatal vs antral lavage cultures in intensive care unit patients. Otolaryngol Head Neck Surg. 2002;126:377–381.
    1. Belden C.J., Zinreich S.J. Orbital imaging techniques. Semin Ultrasound CT MR. 1997;18:413–422.
    1. Klose K.C., Elies W., Sondermann U. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 1991;155:199–206. [The accuracy of plain-film radiology in demonstrating the shadows of the pneumatic spaces of the skull—a comparison with computed tomography]
    1. Melhem E.R., Oliverio P.J., Benson M.L., Leopold D.A., Zinreich S.J. Optimal CT evaluation for functional endoscopic sinus surgery. AJNR Am J Neuroradiol. 1996;17:181–188.
    1. Zinreich S., Kennedy D., Kumar A., Rosenbaum A., Arrington J., Johns M. MR imaging of the normal nasal cycle: comparison with sinus pathology. J Comput Assist Tomogr. 1988;12:1014–1019.
    1. Kennedy D.W. Prognostic factors, outcomes and staging in ethmoid sinus surgery. Laryngoscope. 1992;102:1–18.
    1. Metson R., Gliklich R.E., Stankiewicz J.A. Comparison of sinus computed tomography staging systems. Otolaryngol Head Neck Surg. 1997;117:372–379.
    1. Lund V.J., Mackay I.S. Staging in rhinosinusitis. Rhinology. 1993;31:183–184.
    1. Lloyd G.A., Lund V.J., Scadding G.K. CT of the paranasal sinuses and functional endoscopic surgery: a critical analysis of 100 symptomatic patients. J Laryngol Otol. 1991;105:181–185.
    1. Friedman W.H., Katsantonis G.P., Bumpous J.M. Staging of chronic hyperplastic rhinosinusitis: treatment strategies. Otolaryngol Head Neck Surg. 1995;112:210–214.
    1. Bhattacharyya T., Piccirillo J., Wippold F.J., 2nd Relationship between patient-based descriptions of sinusitis and paranasal sinus computed tomographic findings. Arch Otolaryngol Head Neck Surg. 1997;123:1189–1192.
    1. Levine H.L. Functional endoscopic sinus surgery: evaluation, surgery, and follow-up of 250 patients. Laryngoscope. 1990;100:79–84.
    1. Bhattacharyya N. Test-retest reliability of computed tomography in the assessment of chronic rhinosinusitis. Laryngoscope. 1999;109:1055–1058.
    1. Senior B.A., Kennedy D.W., Tanabodee J., Kroger H., Hassab M., Lanza D. Long-term results of functional endoscopic sinus surgery. Laryngoscope. 1998;108:151–157.
    1. Shields G., Seikaly H., LeBoeuf M. Correlation between facial pain or headache and computed tomography in rhinosinusitis in Canadian and U.S. subjects. Laryngoscope. 2003;113:943–945.
    1. Som P.M., Dillon W.P., Curtin H.D., Fullerton G.D., Lidov M. Hypointense paranasal sinus foci: differential diagnosis with MR imaging and relation to CT findings. Radiology. 1990;176:777–781.
    1. Baroody F.M., Gungor A., deTineo M., Haney L., Blair C., Naclerio R.M. Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine. J Appl Physiol. 1999;87:1038–1047.
    1. Pelikan Z., Pelikan-Filipek M. Role of nasal allergy in chronic maxillary sinusitis—diagnostic value of nasal challenge with allergen. J Allergy Clin Immunol. 1990;86:484–491.
    1. Baroody F., Saengpanich S., deTineo M., Haney L., Votypka V., Naclerio R. Nasal allergen challenge leads to bilateral maxillary sinus eosinophil influx. J Allergy Clin Immunol. 2002;109(suppl):S84. [abstract]
    1. Baroody F., Mucha S., de Tineo M., Malecker B., Naclerio R. Evidence of maxillary sinus inflammation in seasonal allergic rhinitis (SAR) [abstract] J Allergy Clin Immunol. 2003;111(suppl):S124.
    1. Casadevall J., Ventura P.J., Mullol J., Picado C. Intranasal challenge with aspirin in the diagnosis of aspirin intolerant asthma: evaluation of nasal response by acoustic rhinometry. Thorax. 2000;55:921–924.
    1. Togias A. Rhinitis and asthma: evidence for respiratory system integration. J Allergy Clin Immunol. 2003;111:1171–1183.
    1. Djukanovic R., Lai C.K., Wilson J.W. Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls. Eur Respir J. 1992;5:538–544.
    1. Townley R.G., Ryo U.Y., Kolotkin B.M., Kang B. Bronchial sensitivity to methacholine in current and former asthmatic and allergic rhinitis patients and control subjects. J Allergy Clin Immunol. 1975;56:429–442.
    1. Leynaert B., Bousquet J., Neukirch C., Liard R., Neukirch F. Perennial rhinitis: an independent risk factor for asthma in nonatopic subjects: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol. 1999;104:301–304.
    1. Settipane R.J., Hagy G.W., Settipane G.A. Long-term risk factors for developing asthma and allergic rhinitis: a 23-year follow-up study of college students. Allergy Proc. 1994;15:21–25.
    1. Linneberg A., Henrik Nielsen N., Frolund L., Madsen F., Dirksen A., Jorgensen T. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy. 2002;57:1048–1052.
    1. Guerra S., Sherrill D.L., Martinez F.D., Barbee R.A. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol. 2002;109:419–425.
    1. Kapsali T., Horowitz E., Togias A. Rhinitis is ubiquitous in allergic asthmatics. J Allergy Clin Immunol. 1997;99(suppl):S138. [abstract]
    1. Simon R.A. The allergy-asthma connection. Allergy Asthma Proc. 2002;23(4):219–222.
    1. Stephens L., Proud D., Togias A. Nasal cold, dry air (CDA) challenge results in stronger nasal and pulmonary responses in asthmatics compared to patients with rhinitis. J Allergy Clin Immunol. 1996;97:A315. [abstract]
    1. Gaga M., Lambrou P., Papageorgiou N. Eosinophils are a feature of upper and lower airway pathology in non-atopic asthma, irrespective of the presence of rhinitis. Clin Exp Allergy. 2000;30:663–669.
    1. Huse D., Hartz S., Russell M., Piercey G., Weiss S. Allergic rhinitis may worsen asthma symptoms in children: the international asthma outcomes registry. Am J Respir Crit Care Med. 1996;153:A860. [abstract]
    1. Huse D., Hartz S., Klaus D., Piercey G., Richner R., Weiss S. Does allergic rhinitis exacerbate asthma symptoms in adults? The asthma outcomes registry. Eur Respir J. 1996;9(suppl):351S. [abstract]
    1. Huse D., Russell M., Miller J., Weiss S., Hartz S. Asthma treatment costs are increased in children with allergic rhinitis. Eur Respir J. 1998;12(suppl):50S.
    1. Huse D., Hartz S., Klaus D., Kuriyama N., Piercey G., Weiss S. Do symptoms of allergic rhinitis exacerbate asthma symptoms in adults? The asthma outcomes registry. Eur Respir J. 1998;12(suppl):50S.
    1. Halpern M., Richner R., Guo C., de Lissovoy G., Togias A. Allergic rhinitis: a potential cause of increased asthma medication use, costs, and morbidity. J Asthma. 2004;41:117–126.
    1. Chanez P., Vignola A.M., Vic P. Comparison between nasal and bronchial inflammation in asthmatic and control subjects. Am J Respir Crit Care Med. 1999;159:588–595.
    1. Corren J., Adinoff A.D., Irvin C.G. Changes in bronchial responsiveness following nasal provocation with allergen. J Allergy Clin Immunol. 1992;89:611–618.
    1. Tran N., Proud D., Scichilone N., Kosmas E., Togias A. The effect of multiple nasal antigen challenges on the asthmatic airways. J Allergy Clin Immunol. 2000;105(suppl):S282–S283.
    1. Noureddine G., Thompson M., Brennan F. Nasal antigen challenge in asthmatics: effects of cetirizine on nasal and pulmonary responses. J Allergy Clin Immunol. 1994;93:177. [abstract]
    1. Henriksen J.M., Wenzel A. Effect of an intranasally administered corticosteroid (budesonide) on nasal obstruction, mouth breathing, and asthma. Am Rev Respir Dis. 1984;130:1014–1018.
    1. Welsh P.W., Stricker W.E., Chu C.P. Efficacy of beclomethasone nasal solution, flunisolide, and cromolyn in relieving symptoms of ragweed allergy. Mayo Clin Proc. 1987;62:125–134.
    1. Corren J., Adinoff A.D., Buchmeier A.D., Irvin C.G. Nasal beclomethasone prevents the seasonal increase in bronchial responsiveness in patients with allergic rhinitis and asthma. J Allergy Clin Immunol. 1992;90:250–256.
    1. Watson W.T., Becker A.B., Simons F.E. Treatment of allergic rhinitis with intranasal corticosteroids in patients with mild asthma: effect on lower airway responsiveness. J Allergy Clin Immunol. 1993;91:97–101.
    1. Wood R.A., Eggleston P.A. The effects of intranasal steroids on nasal and pulmonary responses to cat exposure. Am J Respir Crit Care Med. 1995;151:315–320.
    1. Foresi A., Pelucchi A., Gherson G., Mastropasqua B., Chiapparino A., Testi R. Once daily intranasal fluticasone propionate (200 micrograms) reduces nasal symptoms and inflammation but also attenuates the increase in bronchial responsiveness during the pollen season in allergic rhinitis. J Allergy Clin Immunol. 1996;98:274–282.
    1. Pelucchi A., Chiapparino A., Mastropasqua B., Marazzini L., Hernandez A., Foresi A. Effect of intranasal azelastine and beclomethasone dipropionate on nasal symptoms, nasal cytology, and bronchial responsiveness to methacholine in allergic rhinitis in response to grass pollens. J Allergy Clin Immunol. 1995;95:515–523.
    1. Dahl R., Baker R., Pauwels R. Seasonal rhinitis and asthma. Effects of topical nasal and/or orally inhaled fluticasone proponiate. The SPIRA study (FNM40001) J Allergy Clin Immunol. 2001;107(suppl):S154. [abstract]
    1. Crystal-Peters J., Neslusan C., Crown W.H., Torres A. Treating allergic rhinitis in patients with comorbid asthma: the risk of asthma-related hospitalizations and emergency department visits. J Allergy Clin Immunol. 2002;109:57–62.
    1. Bresciani M., Paradis L., Des Roches A. Rhinosinusitis in severe asthma. J Allergy Clin Immunol. 2001;107:73–80.
    1. Harlin S.L., Ansel D.G., Lane S.R., Myers J., Kephart G.M., Gleich G.J. A clinical and pathologic study of chronic sinusitis: the role of the eosinophil. J Allergy Clin Immunol. 1988;81:867–875.
    1. Jankowski R., Moneret-Vautrin D.A., Goetz R., Wayoff M. Incidence of medico-surgical treatment for nasal polyps on the development of associated asthma. Rhinology. 1992;30:249–258.
    1. Jankowski R., Pigret D., Decroocq F. Comparison of functional results after ethmoidectomy and nasalization for diffuse and severe nasal polyposis. Acta Otolaryngol. 1997;117:601–608.
    1. Rachelefsky G.S., Katz R.M., Siegel S.C. Chronic sinus disease with associated reactive airway disease in children. Pediatrics. 1984;73:526–529.
    1. Johansson S.G., Hourihane J.O., Bousquet J. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy. 2001;56:813–824.
    1. Garbutt J.M., Goldstein M., Gellman E., Shannon W., Littenberg B. A randomized, placebo-controlled trial of antimicrobial treatment for children with clinically diagnosed acute sinusitis. Pediatrics. 2001;107:619–625.
    1. Werning J.W., Preston T.W., Khuder S. Physician specialty is associated with differences in the evaluation and management of acute bacterial rhinosinusitis. Arch Otolaryngol Head Neck Surg. 2002;128:123–130.
    1. Wasserfallen J.B., Gold K., Schulman K.A., Baraniuk J.N. Development and validation of a rhinoconjunctivitis and asthma symptom score for use as an outcome measure in clinical trials. J Allergy Clin Immunol. 1997;100:16–22.
    1. Rosenfeld R.M. Pilot study of outcomes in pediatric rhinosinusitis. Arch Otolaryngol Head Neck Surg. 1995;121:729–736.
    1. Bucknall C.E. Definitions of severity and outcome measures. Respir Med. 1996;90:447–452.
    1. Harvey R.P., Comer C., Sanders B. Model for outcomes assessment of antihistamine use for seasonal allergic rhinitis. J Allergy Clin Immunol. 1996;97:1233–1241.
    1. Fahmy F.F., McCombe A., McKiernan D.C. Sino nasal assessment questionnaire, a patient focused, rhinosinusitis specific outcome measure. Rhinology. 2002;40:195–197.
    1. Senior B.A., Glaze C., Benninger M.S. Use of the Rhinosinusitis Disability Index (RSDI) in rhinologic disease. Am J Rhinol. 2001;15:15–20.
    1. Druce H.M. Diagnosis of sinusitis in adults: history, physical examination, nasal cytology, echo, and rhinoscope. J Allergy Clin Immunol. 1992;90:436–441.
    1. Fokkens W.J. Thoughts on the pathophysiology of nonallergic rhinitis. Curr Allergy Asthma Rep. 2002;2:203–209.
    1. Hamilos D.L. Chronic sinusitis. J Allergy Clin Immunol. 2000;106:213–227.
    1. Druce H.M., Bonner R.F., Patow C., Choo P., Summers R.J., Kaliner M.A. Response of nasal blood flow to neurohormones as measured by laser-Doppler velocimetry. J Appl Physiol. 1984;57:1276–1283.
    1. Havas T.E., Motbey J.A., Gullane P.J. Prevalence of incidental abnormalities on computed tomographic scans of the paranasal sinuses. Arch Otolaryngol Head Neck Surg. 1988;114:856–859.
    1. Mudgil S.P., Wise S.W., Hopper K.D., Kasales C.J., Mauger D., Fornadley J.A. Correlation between presumed sinusitis-induced pain and paranasal sinus computed tomographic findings. Ann Allergy Asthma Immunol. 2002;88:223–226.
    1. Sinus and Allergy Health Partnership Antimicrobial treatment guidelines for acute bacterial sinusitis. Otolaryngol Head Neck Surg. 2000;123(suppl):S4–S31.
    1. Hickner J.M., Bartlett J.G., Besser R.E., Gonzales R., Hoffman J.R., Sande M.A. Principles of appropriate antibiotic use for acute rhinosinusitis in adults: background. Ann Intern Med. 2001;134:498–505.
    1. Georgitis J.W., Druce H.M., Goldstein S., Upper Airway Allergy Committee Rhinopharyngolaryngoscopy. J Allergy Clin Immunol. 1993;91:961–962.
    1. Lund V.J., Kennedy D.W. Staging for rhinosinusitis. Otolaryngol Head Neck Surg. 1997;117(suppl):S35–S40.
    1. Slavin R.G., Leipzig J.R., Goodgold H.M. “Allergic sinusitis” revisited. Ann Allergy Asthma Immunol. 2000;85:273–276.
    1. Mings R., Friedman W., Linford P. Five-year follow-up of the effects of bilateral intranasal sphenoethmoidectomy in patients with sinusitis and asthma. Am J Rhinol. 1988;2:13–16.
    1. Friedman W.H. Surgery for chronic hyperplastic rhinosinusitis. Laryngoscope. 1975;85:1999–2011.
    1. Chambers D.W., Davis W.E., Cook P.R., Nishioka G.J., Rudman D.T. Long-term outcome analysis of functional endoscopic sinus surgery: correlation of symptoms with endoscopic examination findings and potential prognostic variables. Laryngoscope. 1997;107:504–510.
    1. Jakobsen J., Svendstrup F. Functional endoscopic sinus surgery in chronic sinusitis—a series of 237 consecutively operated patients. Acta Otolaryngol Suppl. 2000;543:158–161.
    1. Blomqvist E.H., Lundblad L., Anggard A., Haraldsson P.O., Stjarne P. A randomized controlled study evaluating medical treatment versus surgical treatment in addition to medical treatment of nasal polyposis. J Allergy Clin Immunol. 2001;107:224–228.
    1. Benninger M., Ferguson B., Hadley J. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg. 2003;129(suppl):S1–S32.
    1. Anon J., Jacobs M., Poole M. Antimicrobial treatment guidelines for acute bacterial rhinosinusitis. Otolaryngol Head Neck Surg. 2004;130:1–45.

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