Feasibility and effectiveness of prone position ventilation technique for postoperative acute lung injury in infants with congenital heart disease: study protocol for a prospective randomized study

Yu-Lu Xu, Ya-Ping Mi, Meng-Xin Zhu, Yue-Hong Ren, Wei-Juan Gong, Wei-Jia Fu, Hui-Mei Wang, Lan Ye, Yin Wang, Xiao-Yan Zhou, Yan Chen, Yan-Yan Chen, Li-Qiong Gu, Ying Gu, Bing Jia, Jing Hu, Xiao-Jing Hu, Yu-Lu Xu, Ya-Ping Mi, Meng-Xin Zhu, Yue-Hong Ren, Wei-Juan Gong, Wei-Jia Fu, Hui-Mei Wang, Lan Ye, Yin Wang, Xiao-Yan Zhou, Yan Chen, Yan-Yan Chen, Li-Qiong Gu, Ying Gu, Bing Jia, Jing Hu, Xiao-Jing Hu

Abstract

Background: Prone position ventilation is a widely used lung protection ventilation strategy. The strategy is more convenient to implement in children compared to adults. Due to the precise mechanism of improving oxygenation function, development of pediatric prone ventilation technology has been largely focused on children with acute respiratory distress syndrome. There is a paucity of high-quality studies investigating the effects of prone position ventilation after pediatric cardiac surgery. The purpose of this study is to evaluate the feasibility and effectiveness of prone position ventilation in infants who develop postoperative acute lung injury after surgery for congenital heart disease.

Methods: A single-center, randomized controlled trial of pediatric patients with acute lung injury after surgery for congenital heart disease who will receive prone position ventilation or usual care (control group). A total of 68 children will be enrolled according to the inclusion criteria. The main outcome measures will be lung compliance and oxygenation index. The secondary outcomes will be duration of mechanical ventilation, length of stay in cardiac intensive care unit, reintubation rate, and complication rate.

Discussion: This study will investigate the feasibility and effectiveness of prone position ventilation techniques in children who develop postoperative acute lung injury after surgery for congenital heart disease. The results may help inform strategies to improve airway management after surgery for congenital heart disease.

Trial registration: ClinicalTrials.gov NCT04607993 . Initially registered on 29 October 2020.

Keywords: Congenital heart disease; Pediatric; Prone position ventilation.

Conflict of interest statement

The authors declare that they have no competing interests.

© 2021. The Author(s).

Figures

Fig. 1
Fig. 1
Flow chart providing an overview of important trial steps. First, understand the research situation and methods of this study at home and abroad through the literature, and then conduct a pre-test, correct the research deviation through the pre-test, and randomly group according to the allowance standard, determine the intervention group and the control group, and conduct data collection. Entry and statistical analysis

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Source: PubMed

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