Characterization of changes in total body composition for patients with head and neck cancer undergoing chemoradiotherapy using dual-energy x-ray absorptiometry
William Jackson, Neil Alexander, Matthew Schipper, Lorraine Fig, Felix Feng, Shruti Jolly, William Jackson, Neil Alexander, Matthew Schipper, Lorraine Fig, Felix Feng, Shruti Jolly
Abstract
Background: Patients with head and neck cancer experience significant weight loss secondary to concurrent chemoradiotherapy (CCRT). Using dual-energy X-ray absorptiometry (DEXA) scans, we characterize total body composition changes during and after CCRT in order to develop novel clinical care models that will improve the patient's quality of life (QOL).
Methods: Sixty DEXA scans were obtained from 12 patients undergoing CCRT for locally advanced squamous cell head and neck cancer. DEXAs were performed at baseline, during treatment, completion of CCRT, and then 1 and 2 months posttreatment.
Results: Mean weight loss by treatment end was 9.5 kg (10.2%; p = .0002). On average, lean body mass (LBM) decreased 10.2% (p = .001), and fat body mass (FBM) decreased 11.1% (p = .001) during CCRT. LBM began to normalize after completion of treatment, whereas FBM continued to decline.
Conclusion: Substantial loss of muscle and FBM occurs in patients undergoing CCRT for head and neck cancer. To prevent long-term disability and QOL decline after curative CCRT, clinical care interventions incorporating aggressive nutrition/exercise counseling are needed.
Keywords: chemoradiotherapy; dual-energy x-ray absorptiometry (DEXA); head and neck cancer; lean body mass; total body composition.
Copyright © 2013 Wiley Periodicals, Inc.
Source: PubMed