Moderate-to-vigorous physical activity as a mediator between sedentary behavior and cardiometabolic risk in Spanish healthy adults: a mediation analysis

Antonio García-Hermoso, Vicente Martínez-Vizcaíno, Mairena Sánchez-López, Jose I Recio-Rodriguez, Manuel A Gómez-Marcos, Luis García-Ortiz, EVIDENT Group, L Garcia Ortiz, M A Gómez Marcos, J I Recio Rodriguez, M C Patino Alonso, M C Castaño Sánchez, C Rodríguez Martín, C Agudo Conde, E Rodríguez Sánchez, L J González Elena, C Herrero Rodríguez, B Sánchez Salgado, A de Cabo Laso, J A Maderuelo Fernández, C Martín Cantera, J Canales Reina, E Rodrigo de Pablo, M L Lasaosa Medina, M J Calvo Aponte, A Rodríguez Franco, E Briones Carrio, C Martin Borras, A Puig Ribera, R Colominas Garrido, J Anton Alvarez, Ma T Vidal Sarmiento, Á Viaplana Serra, S Bermúdez Chillida, A Tanasa, M Romaguera Bosch, M M Domingo, A Girona, N Curos, F J Mezquiriz, L Torrent, A Cabrejas Sánchez, M T Pérez Rodríguez, M L García García, J L Bartolomé, F Salcedo Aguilar, C Fernández Alonso, A Gómez Arranz, E Ibáñez Jalón, A de la Cal de la Fuente, N Gutiérrez, L Muñoz, M Menéndez, I Repiso, R Sanz Cantalapiedra, L M Quintero González, S de Francisco Velasco, M Á Diez García, E Sierra Quintana, M Cáceres, N González Viejo, J F Magdalena Belio, L Otegui Ilarduya, F Ja Rubio Galán, A Melguizo Bejar, C I Sauras Yera, Ma J Gil Train, M Iribarne Ferrer, M Á Lafuente Ripolles, G Grandes, A Sanchez, N Guenaga, V Arce, M S Arietaleanizbealoa, E Iturregui San Nicolás, R A Martín Santidrián, A Zuazagoitia, Antonio García-Hermoso, Vicente Martínez-Vizcaíno, Mairena Sánchez-López, Jose I Recio-Rodriguez, Manuel A Gómez-Marcos, Luis García-Ortiz, EVIDENT Group, L Garcia Ortiz, M A Gómez Marcos, J I Recio Rodriguez, M C Patino Alonso, M C Castaño Sánchez, C Rodríguez Martín, C Agudo Conde, E Rodríguez Sánchez, L J González Elena, C Herrero Rodríguez, B Sánchez Salgado, A de Cabo Laso, J A Maderuelo Fernández, C Martín Cantera, J Canales Reina, E Rodrigo de Pablo, M L Lasaosa Medina, M J Calvo Aponte, A Rodríguez Franco, E Briones Carrio, C Martin Borras, A Puig Ribera, R Colominas Garrido, J Anton Alvarez, Ma T Vidal Sarmiento, Á Viaplana Serra, S Bermúdez Chillida, A Tanasa, M Romaguera Bosch, M M Domingo, A Girona, N Curos, F J Mezquiriz, L Torrent, A Cabrejas Sánchez, M T Pérez Rodríguez, M L García García, J L Bartolomé, F Salcedo Aguilar, C Fernández Alonso, A Gómez Arranz, E Ibáñez Jalón, A de la Cal de la Fuente, N Gutiérrez, L Muñoz, M Menéndez, I Repiso, R Sanz Cantalapiedra, L M Quintero González, S de Francisco Velasco, M Á Diez García, E Sierra Quintana, M Cáceres, N González Viejo, J F Magdalena Belio, L Otegui Ilarduya, F Ja Rubio Galán, A Melguizo Bejar, C I Sauras Yera, Ma J Gil Train, M Iribarne Ferrer, M Á Lafuente Ripolles, G Grandes, A Sanchez, N Guenaga, V Arce, M S Arietaleanizbealoa, E Iturregui San Nicolás, R A Martín Santidrián, A Zuazagoitia

Abstract

Background: Public health strategies for cardiovascular prevention highlight the importance of physical activity, but do not consider the additional potentially harmful effects of sedentary behavior. This study was conducted between 2010 and 2012 and analyzed between 2013 and 2014. The aim of the study was to analyze the relationship between sedentary behavior and cardiometabolic risk factors in the Spanish adult population and to examine whether this relationship is mediated by moderate-to-vigorous physical activity (MVPA).

Methods: The cross-sectional study included 1122 healthy subjects belonging to the EVIDENT study. Sedentary behavior was objectively measured over 7 days using Actigraph accelerometers. We assessed waist circumference (WC), triglycerides-to-HDL-C ratio (TG/HDL-C), and mean arterial pressure (MAP), and undertook homeostasis model assessment (HOMA-IR). Linear regression models were fitted according to Baron and Kenny procedures for mediation analysis.

Results: TG/HDL-C and HOMA-IR were significantly higher in adults who spent more minutes in sedentary activities after adjusting for potential covariates. However when MVPA was added to the ANCOVA models as covariate the effect of sedentary time on HOMA-IR disappeared. In addition, MVPA acted as a full mediator of the relationship between sedentary time and HOMA-IR. In contrast, subjects with lower levels of MVPA presented worse cardiometabolic profiles than those from higher MVPA categories, even after controlling for sedentary time and other potential confounders.

Conclusions: These results suggest that both MVPA and sedentary time should be considered when developing cardiometabolic risk guidelines.

Trial registration: NCT01083082 .

Figures

Fig. 1
Fig. 1
MVPA mediation model of the relationship between sedentary time and HOMA-IR, adjusting for potential confounders, by sex. Data in roman type refer to men. Data in italics refer to women. ap ≤ 0.05; bp ≤ 0.001

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