Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 studies
Dominic E Dwyer, INSIGHT Influenza Study Group, Dominic E Dwyer, Richard T Davey, Marcello H Losso, Ruth Lynfield, Alessandro Cozzi-Lepri, Daniela Gey, Kathy Herman-Lamin, Anne Hoppe, H Clifford Lane, Jens D Lundgren, James D Neaton, Sarah L Pett, Barbara Standridge, Timothy M Uyeki, Deborah Wentworth, David Munroe, Claire Rappoport, Siegfried Schwarze, Bitten Aagaard, Dejan Adzic, Jesper Grarup, Patricia Herrero, Per Jansson, Jesper Kjær, Marie Louise Jakobsen, Birgitte Jensen, Karoline B Jensen, Heidi Juncher, Paco Lopez, Amanda Mocroft, Mary Pearson, Begoña Portas, Caroline Sabin, Klaus Tillmann, Abdel Babiker, Nafisah Braimah, Yolanda Collaco-Moraes, Fleur Hudson, Ischa Kummeling, Filippo Pacciarini, Nick Paton, Alain DuChene, Michelle George, Merrie Harrison, Eric Krum, Gregg Larson, Ray Nelson, Kien Quan, Siu-Fun Quan, Cavan Reilly, Terri Schultz, Greg Thompson, Nicole Wyman, Anchalee Avihingsanon, Lara Cassar, Kanlaya Charoentonpuban, Sean Emery, Kobkeaw Laohajinda, Thidarat Jupimai, Isabel Lanusse, Alejandra Moricz, Ines Otegui, Kiat Ruxrungtham, Rose Robson, Elizabeth Finley, Fred Gordin, Adriana Sanchez, Michael Vjecha, John Baxter, Shawn Brown, Elodie Ghedin, Rebecca Halpin, Marie Hoover, Beth Baseler, Julia A Metcalf, Nancy Cox, Larisa Gubareva, Kathy Hancock, Jackie Katz, Alexander Klimov, Michael Shaw, Lewis Rubinson, Laura Barcan, Jorge Alberto Corral, Daniel Omar David, Hector Enrique Laplume, Maria Beatriz Lasala, Gustavo Daniel Lopardo, Marcelo H Losso, Sergio Lupo, Eduardo Warley, Mark Bloch, Dominic E Dwyer, Richard Moore, Sarah L Pett, Norman Roth, Tuck Meng Soo, Emanuel Vlahakis, Heinz Burgmann, Nathan Clumeck, Stephan De Wit, Eric Florence, Kabamba Kabeya, Jozef Weckx, Carlos Perez, Marcelo J Wolff, Jan Gerstoft, Jens D Lundgren, Lars Østergaard, Kai Zilmer, Johannes R Bogner, Norbert H Brockmeyer, Gerd Faetkenheuer, Hartwig Klinker, Andreas Plettenberg, Juergen Rockstroh, Christoph Stephan, Anastasia Antoniadou, Georgios Koratzanis, Nikolaos Koulouris, Vlassis Polixronopoulos, Helen Sambatakou, Nikolaos Vasilopoulos, Saulius Caplinskas, Alberto La Rosa, Fernando Mendo, Raul Salazar, Jorge Valencia, Elzbieta Bakowska, Andrzej Horban, Brygida Knysz, Francisco Antunes, Manuela Doroana, Nesri Padayatchi, David Dalmau, Eduardo Fernandez-Cruz, Jose Maria Gatell, Jesus Sanz Sanz, Vincent Soriano, Ploenchan Chetchotisakd, Kiat Ruxrungtham, Gompol Suwanpimolkul, Clifford L S Leen, Calvin Cohen, David L Cohn, Jack A DeHovitz, Wafaa El-Sadr, Marshall Glesby, Fred M Gordin, Sally Hodder, Norman Markowitz, Richard M Novak, Robert Schooley, Gary L Simon, Ellen Marie Tedaldi, Zelalem Temesgen, Joseph Timpone, Daniel Z Uslan, Barbara Heeter, Laura Barcan, Jorge Alberto Corral, Daniel Omar David, Hector Enrique Laplume, Maria Beatriz Lasala, Gustavo Daniel Lopardo, Marcelo H Losso, Eduardo Warley, Dominic E Dwyer, Julian Elliott, Pam Konecny, John McBride, Sarah L Pett, Heinz Burgmann, Nathan Clumeck, Stephan De Wit, Philippe Jorens, Kabamba Kabeya, Marcelo J Wolff, Tak Chiu, Wu, Jan Gerstoft, Lars Mathiesen, Henrik Nielsen, Lars Ostergaard, Svend Stenvang, Pedersen, Frank Bergmann, Johannes R Bogner, Norbert H Brockmeyer, Gerd Faetkenheuer, Hartwig Klinker, Juergen Rockstroh, Christoph Stephan, Anastasia Antoniadou, Georgios Koratzanis, Nikolaos Koulouris, Vlassis Polixronopoulos, Helen Sambatakou, Nikolaos Vasilopoulos, Anne Maagaard, Fernando Mendo, Raul Salazar, Elzbieta Bakowska, Andrzej Horban, Nesri Padayatchi, David Dalmau, Vicente Estrada, Eduardo Fernandez-Cruz, Hernando Knobel, Freud, Rosa M Blazquez Garrido, Jose Maria Gatell, Jose Sanz Moreno, Jose Ramon Pano-Pardo, Jesus Sanz Sanz, Vincent Soriano, Ploenchan Chetchotisakd, Kiat Ruxrungtham, Gompol Suwanpimolkul, Brian J Angus, David R Chadwick, David Dockrell, Clifford L S Leen, Melanie Newport, Ed Wilkins, Harry Anderson 3rd, Jason V Baker, David L Cohn, Jack A DeHovitz, Wafaa El-Sadr, Matthew S Freiberg, Fred M Gordin, Roy Gulick, David Gurka, Sally Hodder, Norman Markowitz, Richard M Novak, Armando Paez, Namrata Patil, Annette Reboli, Michael Sands, Robert Schooley, Gary L Simon, Zelalem Temesgen, Joseph Timpone, Daniel Z Uslan, Barbara Heeter Wade, Dominic E Dwyer, INSIGHT Influenza Study Group, Dominic E Dwyer, Richard T Davey, Marcello H Losso, Ruth Lynfield, Alessandro Cozzi-Lepri, Daniela Gey, Kathy Herman-Lamin, Anne Hoppe, H Clifford Lane, Jens D Lundgren, James D Neaton, Sarah L Pett, Barbara Standridge, Timothy M Uyeki, Deborah Wentworth, David Munroe, Claire Rappoport, Siegfried Schwarze, Bitten Aagaard, Dejan Adzic, Jesper Grarup, Patricia Herrero, Per Jansson, Jesper Kjær, Marie Louise Jakobsen, Birgitte Jensen, Karoline B Jensen, Heidi Juncher, Paco Lopez, Amanda Mocroft, Mary Pearson, Begoña Portas, Caroline Sabin, Klaus Tillmann, Abdel Babiker, Nafisah Braimah, Yolanda Collaco-Moraes, Fleur Hudson, Ischa Kummeling, Filippo Pacciarini, Nick Paton, Alain DuChene, Michelle George, Merrie Harrison, Eric Krum, Gregg Larson, Ray Nelson, Kien Quan, Siu-Fun Quan, Cavan Reilly, Terri Schultz, Greg Thompson, Nicole Wyman, Anchalee Avihingsanon, Lara Cassar, Kanlaya Charoentonpuban, Sean Emery, Kobkeaw Laohajinda, Thidarat Jupimai, Isabel Lanusse, Alejandra Moricz, Ines Otegui, Kiat Ruxrungtham, Rose Robson, Elizabeth Finley, Fred Gordin, Adriana Sanchez, Michael Vjecha, John Baxter, Shawn Brown, Elodie Ghedin, Rebecca Halpin, Marie Hoover, Beth Baseler, Julia A Metcalf, Nancy Cox, Larisa Gubareva, Kathy Hancock, Jackie Katz, Alexander Klimov, Michael Shaw, Lewis Rubinson, Laura Barcan, Jorge Alberto Corral, Daniel Omar David, Hector Enrique Laplume, Maria Beatriz Lasala, Gustavo Daniel Lopardo, Marcelo H Losso, Sergio Lupo, Eduardo Warley, Mark Bloch, Dominic E Dwyer, Richard Moore, Sarah L Pett, Norman Roth, Tuck Meng Soo, Emanuel Vlahakis, Heinz Burgmann, Nathan Clumeck, Stephan De Wit, Eric Florence, Kabamba Kabeya, Jozef Weckx, Carlos Perez, Marcelo J Wolff, Jan Gerstoft, Jens D Lundgren, Lars Østergaard, Kai Zilmer, Johannes R Bogner, Norbert H Brockmeyer, Gerd Faetkenheuer, Hartwig Klinker, Andreas Plettenberg, Juergen Rockstroh, Christoph Stephan, Anastasia Antoniadou, Georgios Koratzanis, Nikolaos Koulouris, Vlassis Polixronopoulos, Helen Sambatakou, Nikolaos Vasilopoulos, Saulius Caplinskas, Alberto La Rosa, Fernando Mendo, Raul Salazar, Jorge Valencia, Elzbieta Bakowska, Andrzej Horban, Brygida Knysz, Francisco Antunes, Manuela Doroana, Nesri Padayatchi, David Dalmau, Eduardo Fernandez-Cruz, Jose Maria Gatell, Jesus Sanz Sanz, Vincent Soriano, Ploenchan Chetchotisakd, Kiat Ruxrungtham, Gompol Suwanpimolkul, Clifford L S Leen, Calvin Cohen, David L Cohn, Jack A DeHovitz, Wafaa El-Sadr, Marshall Glesby, Fred M Gordin, Sally Hodder, Norman Markowitz, Richard M Novak, Robert Schooley, Gary L Simon, Ellen Marie Tedaldi, Zelalem Temesgen, Joseph Timpone, Daniel Z Uslan, Barbara Heeter, Laura Barcan, Jorge Alberto Corral, Daniel Omar David, Hector Enrique Laplume, Maria Beatriz Lasala, Gustavo Daniel Lopardo, Marcelo H Losso, Eduardo Warley, Dominic E Dwyer, Julian Elliott, Pam Konecny, John McBride, Sarah L Pett, Heinz Burgmann, Nathan Clumeck, Stephan De Wit, Philippe Jorens, Kabamba Kabeya, Marcelo J Wolff, Tak Chiu, Wu, Jan Gerstoft, Lars Mathiesen, Henrik Nielsen, Lars Ostergaard, Svend Stenvang, Pedersen, Frank Bergmann, Johannes R Bogner, Norbert H Brockmeyer, Gerd Faetkenheuer, Hartwig Klinker, Juergen Rockstroh, Christoph Stephan, Anastasia Antoniadou, Georgios Koratzanis, Nikolaos Koulouris, Vlassis Polixronopoulos, Helen Sambatakou, Nikolaos Vasilopoulos, Anne Maagaard, Fernando Mendo, Raul Salazar, Elzbieta Bakowska, Andrzej Horban, Nesri Padayatchi, David Dalmau, Vicente Estrada, Eduardo Fernandez-Cruz, Hernando Knobel, Freud, Rosa M Blazquez Garrido, Jose Maria Gatell, Jose Sanz Moreno, Jose Ramon Pano-Pardo, Jesus Sanz Sanz, Vincent Soriano, Ploenchan Chetchotisakd, Kiat Ruxrungtham, Gompol Suwanpimolkul, Brian J Angus, David R Chadwick, David Dockrell, Clifford L S Leen, Melanie Newport, Ed Wilkins, Harry Anderson 3rd, Jason V Baker, David L Cohn, Jack A DeHovitz, Wafaa El-Sadr, Matthew S Freiberg, Fred M Gordin, Roy Gulick, David Gurka, Sally Hodder, Norman Markowitz, Richard M Novak, Armando Paez, Namrata Patil, Annette Reboli, Michael Sands, Robert Schooley, Gary L Simon, Zelalem Temesgen, Joseph Timpone, Daniel Z Uslan, Barbara Heeter Wade
Abstract
The novel pandemic influenza A (H1H1) 2009 virus spread rapidly around the world in 2009. The paucity of prospective international epidemiologic data on predictors of clinical outcomes with pandemic (H1N1) 2009 virus infection stimulated the INSIGHT network, an international network of community and hospital-based investigators, to commence two worldwide clinical observational studies to describe pandemic (H1N1) 2009 virus activity. The purpose of these two studies was to estimate the percent of adult patients with illness due to laboratory-confirmed pandemic (H1N1) 2009 virus infection that experience clinically significant outcomes and to study factors related to these outcomes. Enrollment commenced in October 2009 and will continue until August 2011: as of the end of 2010, 62 sites in 14 countries in Australasia (12 sites), Europe (37) and North America (13) have enrolled 1365 adult patients, with 1049 enrollments into the FLU 002 outpatient study and 316 into the FLU 003 hospitalization study. These 'in progress' INSIGHT influenza observational studies may act as a model for obtaining epidemiological, clinical and laboratory information in future international disease outbreaks.
Conflict of interest statement
The Writing Group reports no conflicts of interest.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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Source: PubMed