Immunoglobulin G kappa [IgG kappa] and IgG lambda paraproteinemia in a child with AIDS and response to highly active antiretroviral therapy

Abstract

We report an 8-year-old boy with AIDS, extremely elevated serum immunoglobulin G (IgG) concentration and IgG kappa [IgG(kappa)] and IgG lambda [IgG(lambda)] paraproteinemia. This paraproteinemia partially responded to highly active antiretroviral therapy. This case emphasizes the importance of controlling B-cell activation.

Figures

FIG. 1.

Immunofixation of (A) the patient's serum prior to treatment (age, 7.5 years old) and (B) the patient's serum after treatment (age, 8 years old). Prior to treatment, the serum contained three IgG monoclonal bands: two monoclonal IgG(κ) bands and one monoclonal IgG(λ) band. After treatment, one of the previously identified monoclonal IgG(κ) bands is no longer identifiable. The letters at the top of the figure represent the following: ELP, electrophoresis; G, IgG; A, IgA; M, IgM; K, kappa light chain; L, lambda light chain.