Absence of effect of trimethoprim-sulfamethoxazole on pharmacokinetics of zidovudine in patients infected with human immunodeficiency virus

E Cañas, J Pachon, F Garcia-Pesquera, J R Castillo, P Viciana, J M Cisneros, M E Jimenez-Mejias, E Cañas, J Pachon, F Garcia-Pesquera, J R Castillo, P Viciana, J M Cisneros, M E Jimenez-Mejias

Abstract

Pharmacokinetic parameters of zidovudine (ZDV) were not altered in 16 patients receiving concomitant therapy with ZDV and trimethoprim-sulfamethoxazole by oral administration. ZDV areas under the concentration-time curves were (means +/- standard deviations) 1.80 +/- 0.70 and 1.69 +/- 0.64 micrograms.h/ml in the absence and presence of trimethoprim-sulfamethoxazole, respectively. ZDV clearances were 1.57 +/- 0.61 and 1.74 +/- 0.66 liters/h/kg, respectively.

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