Fundamentals of Neurogastroenterology: Basic Science
Stephen Vanner, Beverley Greenwood-Van Meerveld, Gary Mawe, Terez Shea-Donohue, Elena F Verdu, Jackie Wood, David Grundy, Stephen Vanner, Beverley Greenwood-Van Meerveld, Gary Mawe, Terez Shea-Donohue, Elena F Verdu, Jackie Wood, David Grundy
Abstract
This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled ROME IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs and new areas for future research into their pathophysiology.
Keywords: enteric nervous system; mucosal barrier function; neuroimmune signaling; sensory physiology.
Conflict of interest statement
Conflicts of interest
The authors disclose no conflicts.
Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.
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Source: PubMed