Dengue seroprevalence in a cohort of schoolchildren and their siblings in Yucatan, Mexico (2015-2016)

Norma Pavía-Ruz, Gloria Abigail Barrera-Fuentes, Salha Villanueva-Jorge, Azael Che-Mendoza, Julio César Campuzano-Rincón, Pablo Manrique-Saide, Diana Patricia Rojas, Gonzalo M Vazquez-Prokopec, M Elizabeth Halloran, Ira M Longini, Héctor Gómez-Dantés, Norma Pavía-Ruz, Gloria Abigail Barrera-Fuentes, Salha Villanueva-Jorge, Azael Che-Mendoza, Julio César Campuzano-Rincón, Pablo Manrique-Saide, Diana Patricia Rojas, Gonzalo M Vazquez-Prokopec, M Elizabeth Halloran, Ira M Longini, Héctor Gómez-Dantés

Abstract

Background: The implementation of vector control interventions and potential introduction new tools requires baseline data to evaluate their direct and indirect effects. The objective of the study is to present the seroprevalence of dengue infection in a cohort of children 0 to 15 years old followed during 2015 to 2016, the risk factors and the role of enhanced surveillance strategies in three urban sites (Merida, Ticul and Progreso) in Yucatan, Mexico.

Methods: A cohort of school children and their family members was randomly selected in three urban areas with different demographic, social conditions and levels of transmission. We included results from 1,844 children aged 0 to 15 years. Serum samples were tested for IgG, NS1 and IgM. Enhanced surveillance strategies were established in schools (absenteeism) and cohort families (toll-free number).

Results: Seroprevalence in children 0 to 15 years old was 46.8 (CI 95% 44.1-49.6) with no difference by sex except in Ticul. Prevalence increased with age and was significantly lower in 0 to 5 years old (26.9%, 95% CI:18.4-35.4) compared with 6 to 8 years old (43.9%, 95% CI:40.1-47.7) and 9 to 15 years old (61.4%, 95% CI:58.0-64.8). Sharing the domestic space with other families increased the risk 1.7 times over the individual families that own or rented their house, while risk was significantly higher when kitchen and bathroom were outside. Complete protection with screens in doors and windows decreased risk of infection. Seroprevalence was significantly higher in the medium and high risk areas.

Conclusions: The prevalence of antibodies in children 0 to 15 years in three urban settings in the state of Yucatan describe the high exposure and the heterogenous transmission of dengue virus by risk areas and between schools in the study sites. The enhanced surveillance strategy was useful to improve detection of dengue cases with the coincident transmission of chikungunya and Zika viruses.

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1. Cohort of families and school…
Fig 1. Cohort of families and school children aged 0 to 15 years old, 2015–2016.
Percent represents blood samples coverage of 0 to 15 years old.
Fig 2. Seroprevalence of school children by…
Fig 2. Seroprevalence of school children by age group and risk areas, Yucatan, 2016.
Seroprevalence is represented by percentage and 95% CI.
Fig 3. Seroprevalence by schools and risk…
Fig 3. Seroprevalence by schools and risk areas, Yucatan, 2016.
Seroprevalence is represented by percentage and 95% CI.

References

    1. Gubler DJ. Dengue, Urbanization and Globalization: The Unholy Trinity of the 21st Century. Trop Med Health. 2011;39(4SUPPLEMENT):S3–11.
    1. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496:504–7.
    1. Capeding MR, Chua MN, Hadinegoro SR, Hussain IIHM, Nallusamy R, Pitisuttithum P, et al. Dengue and other common causes of acute febrile illness in Asia: an active surveillance study in children. PLoS Negl Trop Dis. 2013;7(7):e2331
    1. Perkins TA, Paz-Soldan VA, Stoddard ST, Morrison AC, Forshey BM, Long KC, et al. Calling in sick: impacts of fever on intra-urban human mobility. Proc R Soc B Biol Sci. 2016;283(1834):20160390.
    1. Chávez-Arias NP, Villegas-Chim JE, Wejebe-Shanahan M, Barrera-Buenfil DJ, Rafful-Ceballos MJ, Ramos-Valencia JE, et al. Studying sociocultural factors associated with dengue fever in elementary school children in Yucatan, Mexico. SAGE Research Methods Cases. 2017.
    1. Sarti E, Cox H, Besada-Lombana S, Tapia-Maruri L. Dengue Awareness in Latin American Populations: A Questionnaire Study. Infect Dis Ther. 2015;4(2):199–211.
    1. Balmaseda A, Standish K, Mercado JC, Matute JC, Tellez Y, Saborío S, et al. Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua. J Infec Dis. 2010;201(1):5–14.
    1. Yoon I-K, Rothman AL, Tannitisupawong Darunee, Anon S, Jarman RG, Aldstadt J, Nisalak A, et al. Underrecognized mildly symptomatic viremic dengue virus infections in rural thai schools and villages. J Infect Dis. 2012;206(3):389–98.
    1. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, et al. Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol. 2002;156(1):40–51.
    1. Kikuti M, Cunha GM, Paploski IA, Kasper AM, Silva MM, Tavares AS, et al. Spatial distribution of dengue in a brazilian urban slum setting: role of socioeconomic gradient in disease risk. PLoS Negl Trop Dis. 2015;9(7):e0003937
    1. Cromwell EA, Stoddard ST, Barker CM, Van-Rie A, Messer WB, Meshnick SR, et al. The relationship between entomological indicators of Aedes aegypti abundance and dengue virus infection. PLoS Negl Trop Dis. 2017;11(3):e0005429
    1. Salje H, Lessler J, Berry IM, Melendrez MC, Endy T, Kalayanarooj S, et al. Dengue diversity across spatial and temporal scales: local structure and the effect of host population size. Science (80-). 2017;355:1302–6.
    1. Souza LS, Barradas-Barata R de C. Intra-urbandiferentials in dengue distribution, Cuiabá, 2007–2008. Rev Bras Epidemiol. 2012;15(4):761–70.
    1. Morrison AC, Minnick SL, Rocha C, Forshey BM, Stoddard ST, Getis A, et al. Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. PLoS Negl Trop Dis. 2010;4(5):e670
    1. Luz PM, Codeço CT, Massad E, Struchiner CJ. Uncertainties regarding dengue modeling in Rio de Janeiro, Brazil. Mem Inst Oswaldo Cruz. 2003;98(7):871–8.
    1. Yoksan S, Tubthong K, Kanitwithayanun W, Jirakanjanakit N. Laboratory assays and field dengue vaccine evaluation at Ratchaburi province, Thailand: a preliminary result. J Clin Virol. 2009;46:S13–5.
    1. Endy TP, Yoon I, Mammen MP. Prospective cohort studies of dengue viral transmission and severity of disease En: Rothman AL, editor. Dengue virus, current topics in microbiology and immunology. Springer-Verlag; Berlin Heildelberg; 2010. p. 1–13.
    1. Mammen MP, Pimgate C, Koenraadt CJM, Rothman AL, Aldstadt J, Nisalak A, et al. Spatial and temporal clustering of dengue virus transmission in thai villages. Plos Med. 2008;5(11):e205
    1. Ratanawong P, Kittayapong P, Olanratmanee P, Wilder-smith A, Byass P, Tozan Y, et al. Spatial variations in denguetransmission in schools in Thailand. PLoS One. 2016;11(9):e0161895
    1. Lee J, Mogasale V, Lim JK, Carabali M, Sirivichayakul K, Tho LH, et al. A multi-country study of the household willingness-to-pay for dengue vaccines: household surveys in Vietnam, Thailand, and Colombia. PLoS Negl Trop Dis. 2015;9(6):e0003810
    1. Instituto Nacional de Estadística y Geogragía (INEGI). Anuario de estadísticas por entidad federativa 2010. México; 2010.
    1. Escobar-Mesa J, Gómez-Dantés H. Determinantes de la transmisión de dengue en Veracruz: un abordaje ecológico para su control. Salud Publica Mex. 2003;45(1):43–53.
    1. CYD-TDV Dengue Vaccine Working Group. Efficacy and long-term safety of a dengue vaccine in regions of endemic disease. N Engl J Med. 2015;373:1195–206.
    1. Balmaseda A, Hammond SN, Tellez Y, Imhoff L, Rodriguez Y, Saira I, et al. High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Trop Med Int Heal. 2006;11(6):935–42.
    1. Balmaseda A, Standish K, Mercado JC, Matute JC, Tellez Y, Saborío S, et al. Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua. J Infect Dis. 2010;201(1):5–14.
    1. Castanha PMS, Cordeiro MT, Martelli CMT, Souza WV, Marques ETA, Braga C. Force of infection of dengue serotypes in a population-based study in the northeast of Brazil. Epidemiol Infect. 2013;141:1080–8.
    1. Garg S, Chakravarti A, Singh R, Masthi NRR, Chandra R, Rajesh G, et al. International Journal of Infectious Diseases Dengue serotype-specific seroprevalence among 5- to 10-year-old children in India: a community-based cross-sectional study. Int J Infect Dis. 2017;54:25–30.
    1. Graham RR, Juffrie M, Tan R, Hayes CG, Laksono I, Roef CMA, et al. A prospective seroepidemiologic study on dengue in children four to nine years of age in Yogyakarta, Indonesia I. Studies in 1995–1996. Am J Trop Med Hyg. 1999;61(3):412–9.
    1. Jeewandara C, Gomes L, Paranavitane SA, Tantirimudalige M, Panapitiya SS, Jayewardene A, et al. Change in dengue and japanese encephalitis seroprevalence rates in Sri Lanka. PLoS One. 2015;10(12):e0144799
    1. Thai KTD, Binh TQ, Giao PT, Phuong HL, Hung LQ, Nam VN, et al. Seroprevalence of dengue antibodies, annual incidence and risk factors among children in southern Vietnam. Trop Med Int Heal. 2005;10(4):379–86.
    1. Loroño-Pino MA, Farfán-Ale JA, Rosado-Paredes E del P, Arjona-Torres AI, Flores-Flores L-F, Cabrera-Manzano LA, et al. Prevalencia de anticuerpos contra virus dengue en Yucatán, México, 1985. Rev Lat-amer Microbiol. 1985;31:259–62.
    1. Farfán-Ale JA, Loroño-Pinto MA. The incidence of dengue virus infection in children 8 to 14 years old residing in the urban and rural areas of the city of Mérida, Yucatán. Bol Med Hosp Infant Mex. 1991;48(11):780–4.
    1. Gómez-Caro S, Méndez-Domínguez N, Méndez-Galván JF. Dengue seropositivity in a randomly selected sample from Yucatan analyzed in the context of dengue cases reported between 1996 and 2006. J Epidemiol Res. 2017;3(1):23–7.
    1. Amaya-Larios IY, Martínez-Vega RA, Mayer S V, Galeana-Hernández M, Comas-García A, Sepúlveda-Salinas KJ, et al. Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico. Am J Trop Med Hyg. 2014;91(5):1057–65.
    1. Halstead SB. Dengue in the Americas and Southeast Asia: do they differ? Rev Panam Salud Pública. 2006;20(6):407–15.
    1. San-Martín JL, Brathwaite O, Zambrano B, Solórzano JO, Bouckenooghe A, Dayan GH, et al. The epidemiology of dengue in the Americas over the last three decades: a worrisome reality. Am J Trop Med Hyg. 2010;82(1):128–35.
    1. Shen S, Wei H, Fu Y, Zhang H, Mo Q, Wang X. Multiple Sources of Infection and Potential Endemic Characteristics of the Large Outbreak of Dengue in Guangdong in 2014. Nat Publ Gr. 2015;(May):1–10.
    1. Rodríguez-Barraquer I, Buathong R, Iamsirithaworn S, Nisalak A, Lessler J, Jarman RG, et al. Revisiting rayong: shifting seroprofiles of dengue in Thailand and their implications for transmission and control. Am J Epidemiol. 2014;179(3):353–60.
    1. Braga C, Feitosa-Luna C, Turchi-Martelli CM, Vieira de Souza W, Tenório-Cordeiro M, Alezander N, et al. Seroprevalence and risk factors for dengue infection in socioeconomically distinct areas of Recife, Brazil. Acta Trop. 2013;113(3):16.
    1. Mattos-Almeida MC, Teixeira-Caiaffa W, Martins-Assuncao R, Proietti FA. Spatial vulnerability to dengue in a brazilian urban area during a 7-year surveillance. J urban Heal. 2007;84(3):334–45.
    1. Barrera R, Delgado N, Jiménez M, Villalobos I, Romero I. Estratificación de una ciudad hiperendémica en dengue hemorrxgico. Rev Panam Salud Pública. 2000;8(4):225–33.
    1. Teixeira M da G, Barreto ML, Costa M da CN, Ferreira LDA, Vasconcelos PFC, Cairncross S. Dynamics of dengue virus circulation: a silent epidemic in a complex urban area. Trop Med Int Heal. 2002;7(9):757–62.
    1. Siqueira JB, Maciel IJ, Barcellos C, Souza W V, Carvalho MS, Nascimento NE, et al. Spatial point analysis based on dengue surveys at household level in central Brazil. BMC Public Health. 2008;8:361
    1. Schmidt W, Suzuki M, Thiem VD, White RG, Tsuzuki A, Yoshida L-M, et al. Population density, water supply, and the risk of dengue fever in vietnam: cohort study and spatial analysis. Plos Med. 2011;8(8):e1001082
    1. Manrique-Saide P, Coleman P, McCall PJ, Lenhart A, Vázquez-Prokopec GM, Davies CR. Multi-scale analysis of the associations among egg, larval and pupal surveys and the presence and abundance of adult female Aedes aegypti (Stegomyia aegypti) in the city of Merida, Mexico. Med Vet Entomol. 2014;28(3):264–72.
    1. Vazquez-Prokopec GM, Lenhart A, Manrique-Saide P. Housing improvement: A novel paradigm for urban vector-borne disease control? Trans R Soc Trop Med Hyg. 2016;110(10):567–9.
    1. Lindsay SW, Wilson A, Golding N, Scott TW, Takken W. Improving the built environment in urban areas to control Aedes aegypti-borne diseases. Bull World Health Organ. 2017;95(8):607–8.
    1. Wichmann O, Yoon I, Vong S, Limkittikul K, Gibbons RV, Mammen PM, et al. Dengue in Thailand and Cambodia: an assessment of the degree of underrecognized disease burden based on reported cases. PLoS Negl Trop Dis. 2011;5(3):e996
    1. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, et al. Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis. 2d. C.;5(3):e975.
    1. Rocha C, Morrison AC, Forshey BM, Blair PJ, Olson JG, Stancil JD, et al. Comparison of two active surveillance programs for the detection of clinical dengue cases in Iquitos, Peru. Am J Trop Med Hyg. 2009;80(4):656–60.
    1. Ferguson NM, Rodríguez-Barraquer I, Dorigatti I, Mier-y-Teran-Romero L, Laydon DJ, Cummings DAT. Benefits and risks of the Sanofi-Pasteur dengue vaccine: modeling optimal deployment. Science (80-). 2016;353(6303):1033–6.

Source: PubMed

Patrocinadores e Colaboradores

Condições médicas

Intervenções de drogas

3
Se inscrever