The influence of the choroid on the onset and development of myopia: from perspectives of choroidal thickness and blood flow

Yilin Liu, Lijun Wang, Yanyun Xu, Zuoxiang Pang, Guoying Mu, Yilin Liu, Lijun Wang, Yanyun Xu, Zuoxiang Pang, Guoying Mu

Abstract

Myopia is the most common type of refractive errors characterized by excessive elongation of the ocular globe. With the increasing prevalence of myopia, improved knowledge of factors involved in myopia development is of particular importance. There are growing evidence suggesting that the choroid plays an important role in the regulation of eye growth and the development of myopia. Studies have demonstrated that thinning choroid is a structural feature of myopia, with a negative correlation between choroidal thickness and axial length, suggesting that the change in choroidal thickness may be a predictive biomarker for long-term changes in ocular elongation. Given the fact that the choroid is primarily a vascular structure capable of rapidly changing blood flow, variations of choroidal thickness might be primarily caused by changes in choroidal blood flow. Considering that hypoxia is associated with myopia and choroidal blood flow is the main source of oxygen and nourishment supply, apart from the effect on myopia possibly by changing choroidal thickness, decreasing choroidal blood flow may contribute to scleral ischaemia and hypoxia, resulting in alterations in the scleral structure and thus leading to myopia. This review aims to provide an overview of recent work exploring the influence of the choroid on myopia from perspectives of choroidal thickness and blood flow, which may present new predictive indicators for the onset of myopia and new targets for the development of novel therapeutic approaches for myopia.

Keywords: choroid; choroidal blood flow; choroidal thickness; myopia.

© 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

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