Estimation of radiation dosimetry for 68Ga-HBED-CC (PSMA-11) in patients with suspected recurrence of prostate cancer
Mark A Green, Jacob A Eitel, James W Fletcher, Carla J Mathias, Mark A Tann, Thomas Gardner, Michael O Koch, Wendy Territo, Heather Polson, Gary D Hutchins, Mark A Green, Jacob A Eitel, James W Fletcher, Carla J Mathias, Mark A Tann, Thomas Gardner, Michael O Koch, Wendy Territo, Heather Polson, Gary D Hutchins
Abstract
Introduction: This study was performed to estimate the human radiation dosimetry for [68Ga]Ga-HBED-CC (PSMA-11) (68Ga PSMA-11).
Methods: Under an RDRC-approved research protocol, we evaluated the biodistribution and pharmacokinetics of 68Ga PSMA-11 with serial PET imaging following intravenous administration to nine prostate cancer patients in whom clinical [11C]acetate PET/CT exams had been independently performed under Expanded Access IND 118,204. List-mode imaging was performed over the initial 0-10min post-injection with the pelvis in the field-of-view. Whole-body images were acquired, pelvis-to-head, at 15, 60, and 90-min post-injection. Additional images of the pelvis were acquired at 40-min and 115-min, and voided urine collected from each subject at 48-min and 120-min post-injection. Radiation dosimetry estimates were calculated from these data using the OLINDA software package.
Results: Renal uptake was high and relatively invariant, ranging from 11% to 14% of the injected dose between 15 and 90-min post-injection. Radioactivity collected in the voided urine accounted for 14% of the injected dose over a period of 120-min. Lymph nodes and skeletal metastases suspicious for prostate cancer recurrence were detected in a greater number of patients using 68Ga PSMA-11 than using 11C-acetate.
Conclusion: Kidneys are the critical organ following 68Ga PSMA-11 administration, receiving an estimated dose of 0.413mGy/MBq.
Advances in knowledge and implications for patient care: This study confirms that the kidneys will be the critical organ following intravenous administration of 68Ga PSMA-11, and provided data consistent with the expectation that 68Ga PSMA-11 will be superior to [11C]acetate for defining sites of recurrence in prostate cancer patients presenting with biochemical relapse.
Keywords: (68)Ga-DKFZ-PSMA-11; (68)Ga-HBED-CC (PSMA-11); Dosimetry; Glu-NH-CO-NH-Lys-(Ahx)-[(68)Ga(HBED-CC)]; PSMA-targeted PET/CT; Prostate cancer recurrence.
Copyright © 2016 Elsevier Inc. All rights reserved.
Source: PubMed