Mechanical Thrombectomy in Patients with Acute Ischemic Stroke and Concomitant Intracranial Hemorrhage

Johannes M Weller, Julius N Meissner, Sebastian Stösser, Franziska Dorn, Gabor C Petzold, Felix J Bode, GSR-ET investigators, A Reich, O Nikoubashman, J Röther, B Eckert, M Braun, G F Hamann, E Siebert, C H Nolte, G Bohner, R M Eckert, J Borggrefe, P Schellinger, J Berrouschot, A Bormann, C Kraemer, H Leischner, M Petersen, F Stögbauer, T Boeck-Behrens, S Wunderlich, A Ludolph, K H Henn, C Gerloff, J Fiehler, G Thomalla, A Alegiani, J H Schäfer, F Keil, S Tiedt, L Kellert, C Trumm, U Ernemann, S Poli, J Liman, M Ernst, K Gröschel, T Uphaus, Johannes M Weller, Julius N Meissner, Sebastian Stösser, Franziska Dorn, Gabor C Petzold, Felix J Bode, GSR-ET investigators, A Reich, O Nikoubashman, J Röther, B Eckert, M Braun, G F Hamann, E Siebert, C H Nolte, G Bohner, R M Eckert, J Borggrefe, P Schellinger, J Berrouschot, A Bormann, C Kraemer, H Leischner, M Petersen, F Stögbauer, T Boeck-Behrens, S Wunderlich, A Ludolph, K H Henn, C Gerloff, J Fiehler, G Thomalla, A Alegiani, J H Schäfer, F Keil, S Tiedt, L Kellert, C Trumm, U Ernemann, S Poli, J Liman, M Ernst, K Gröschel, T Uphaus

Abstract

Purpose: Intravenous thrombolysis and mechanical thrombectomy (MT) are standard of care in patients with acute ischemic stroke due to large vessel occlusion. Data on MT in patients with intracranial hemorrhage prior to intervention is limited to anecdotal reports, as these patients were excluded from thrombectomy trials.

Methods: We analyzed patients from an observational multicenter cohort with acute ischemic stroke and endovascular treatment, the German Stroke Registry-Endovascular Treatment trial, with intracranial hemorrhage before MT. Baseline characteristics, procedural parameters and functional outcome at 90 days were analyzed and compared to a propensity score matched cohort.

Results: Out of 6635 patients, we identified 32 patients (0.5%) with acute ischemic stroke due to large vessel occlusion and preinterventional intracranial hemorrhage who underwent MT. Risk factors of intracranial hemorrhage were head trauma, oral anticoagulation and intravenous thrombolysis. Overall mortality was high (50%) but among patients with a premorbid modified Rankin scale (mRS) of 0-2 (n = 15), good clinical outcome (mRS 0-2) at 90 days was achieved in 40% of patients. Periprocedural and outcome results did not differ between patients with and without preinterventional intracranial hemorrhage.

Conclusion: Preinterventional intracranial hemorrhage in acute ischemic stroke patients with large vessel occlusion is rare. The use of MT is technically feasible and a substantial number of patients achieve good clinical outcome, indicating that MT should not be withheld in patients with preinterventional intracranial hemorrhage.

Keywords: Endovascular therapy; Intravenous thrombolysis; Large vessel occlusion; Mechanical thrombectomy; Stroke.

Conflict of interest statement

F. Dorn received research funding from Cerenovus, speakers fees from Cerenovus and Acandis and serves as a proctor and consultant for Cerus Endovascular, Balt and Cerenovus. J.M. Weller, J.N. Meissner, S. Stösser, G.C. Petzold and F.J. Bode declare that they have no competing interests.

© 2022. The Author(s).

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