Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis

Eugene H Chang, Amanda L Willis, Hilary C McCrary, George T Noutsios, Christopher H Le, Alexander G Chiu, Corrine J Mansfield, Danielle R Reed, Steven G Brooks, Nithin D Adappa, James N Palmer, Noam G Cohen, Debra A Stern, Stefano Guerra, Fernando D Martinez, Eugene H Chang, Amanda L Willis, Hilary C McCrary, George T Noutsios, Christopher H Le, Alexander G Chiu, Corrine J Mansfield, Danielle R Reed, Steven G Brooks, Nithin D Adappa, James N Palmer, Noam G Cohen, Debra A Stern, Stefano Guerra, Fernando D Martinez

Abstract

A retrospective, multi-center study of adults with and without chronic rhinosinusitis (CRS) identifies a significant association between rs6967330 in the viral receptor CDHR3 – known to be associated with wheezing and asthma in children – and the development of CRS.

Figures

Figure 1
Figure 1
Meta-analysis of rs6967330 from UofA and UPenn. The rs6967330 SNP is significantly associated with CRS in both additive and dominant models. This association remains significant in those without self-reported asthma (non-asthmatics). mOR was adjusted for sex and age.

Source: PubMed

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