Outpatient parenteral antimicrobial therapy in Germany: a prospective cohort study protocol

Nadine Scholten, Charlotte Leisse, Vanessa Brandes, Charlotte Oberröhrmann, Peter Ihle, Sophie Peter, Anna Hagemeier, Martin Hellmich, Christoph H Lindemann, Christina Samel, Holger Pfaff, Clara Lehmann, Nadine Scholten, Charlotte Leisse, Vanessa Brandes, Charlotte Oberröhrmann, Peter Ihle, Sophie Peter, Anna Hagemeier, Martin Hellmich, Christoph H Lindemann, Christina Samel, Holger Pfaff, Clara Lehmann

Abstract

Introduction: Outpatient parenteral antimicrobial therapy (OPAT) means intravenous administration of antibiotics outside the hospital. The antibiotics are administered at the patient's home. The advantages are the shortening of the inpatient stay, which means that patients can remain in their familiar environment, the reduction of nosocomial infections as well as the reduction of hospital and therapy costs. Nevertheless, OPAT is rarely performed in Germany, despite its international application. Therefore, systematic data on OPAT are not available in Germany. The project objective is to investigate the medical care using OPAT under medical, epidemiological and economic aspects within the framework of the Cologne Network of Infectious Diseases.

Methods and analysis: Observational study with mixed-methods approach, qualitative analysis to identify physician-side factors to assess the attitude of general practitioners in Cologne with regard to possible implementation barriers of an OPAT. Longitudinal analysis of an OPAT patient cohort with respect to clinical and patient-relevant outcomes using descriptive and conclusive statistics.

Ethics and dissemination: The study has been approved by the Institutional Review Board of the University of Cologne, Germany (19-1284-1). Written informed consent was obtained from all participants. The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences.

Trial registration number: NCT04002453.

Keywords: GENERAL MEDICINE (see Internal Medicine); INFECTIOUS DISEASES; Organisation of health services; Quality in health care.

Conflict of interest statement

Competing interests: None declared.

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Figures

Figure 1
Figure 1
Scheme of therapy and study procedure. OPAT, outpatient parenteral antimicrobial therapy.

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