Clinical Radiographic Evaluation of 3Mixtatin and MTA in Primary Teeth Pulpotomies: A Randomized Controlled

Rakesh K Chak, Rajeev K Singh, Jhansi Mutyala, Nidesh K Killi, Rakesh K Chak, Rajeev K Singh, Jhansi Mutyala, Nidesh K Killi

Abstract

Introduction: The present study evaluates the efficiency of 3Mixtatin (a combination of Simvastatin and 3Mix antibiotics) in comparison with Mineral Trioxide Aggregate in primary molars pulpotomy.

Materials and methods: A total of 64 deciduous molar teeth with caries requiring pulpotomy procedure were selected and randomly divided into two treatment groups, Group I- MTA (n = 32), Group II- 3Mixtatin (n = 32). Restoration with Glass Ionomer Cement followed by stainless steel crowns was done after pulpotomy procedure. The clinical and radiographical analysis was done in the subsequent follow-up periods of 3, 6, 9, and12 months simultaneously.

Result: Both groups showed equal success rates, without any significant difference between the MTA and 3mixtatin groups clinically (success rate of 93.8%)and radiographically higher success rate was seen with 3Mixtatin (78% success rate).

Conclusion: 3mixtatin showed similar clinical and better radiographical success rate to MTA. Therefore, 3mixtatin may be a potential alternate pulpotomy medicament in primary teeth.

Key messages: In the present study based on the radiographic findings, 78% success rate was seen in the teeth treated with 3Mixtatin, which was higher than the radiographic success rate of MTA (75%). Therefore, it is reasonable to assume the use of 3Mix with Simvastatin to treat pulpotomized primary molars by 3Mixtatin.

How to cite this article: Chak RK, Singh RK, Mutyala J, et al. Clinical Radiographic Evaluation of 3Mixtatin and MTA in Primary Teeth Pulpotomies: A Randomized Controlled Trial. Int J Clin Pediatr Dent 2022;15(S-1):S80-S86.

Keywords: 3Mixtatin; Biodentin; Primary molars; Pulpotomy.

Conflict of interest statement

Source of support: Nil Conflict of interest: None

Copyright © 2022; The Author(s).

Figures

Figs. 1A to H
Figs. 1A to H
(A) Preoperative photograph; (B) Intraoperative view after removal of coronal pulp tissue; (C) Intraoperative view showing MTA; (D) Preoperative radiograph; (E) 3rd month radiograph; (F) 6th month radiograph; (G) 9th month radiograph; (H) 12th month radiograph
Figs. 2A to I
Figs. 2A to I
(A) Preoperative photograph; (B) Intraoperative view after removal of coronal pulp tissue; (C) Intraoperative view showing 3mixtatin; (D) Intraoperative view showing 3mixtatin placement over radicular pulp; (E) Preoperative radiograph; (F) 3rd month radiograph; (G) 6th month radiograph; (H) 9th month radiograph; (I) 12th month radiograph
Fig. 3
Fig. 3
Success rate of MTA and 3Mixtatin as pulpotomy medicament in primary molars at a follow-up period of 3, 6, 9, and 12 months based on clinical evaluation
Fig. 4
Fig. 4
Success rate of MTA and 3Mixtatin as pulpotomy medicament in primary molars at a follow-up period of 3, 6, 9, and 12 months based on radiographical evaluation

References

    1. Gazi-coklica V, Muretic Z, Brcic R, et al. Craniofacial parameters during growth from the deciduous to permanent dentition—a longitudinal study. Eur J Orthod. 1997;19(6):S80–S86. doi: 10.1093/ejo/19.6.681.
    1. Nanda RS. The rates of growth of several facial components measured from serial cephalometric roentgenograms. Am J Orthod Dentofacial Orthop. 1955;41(09):658–673. doi: 10.1016/0002-9416(55)90112-3.
    1. Dawood A, Patel S, Brown J. Cone beam CT in dental practice. Br Dent J. 2009;207(01):23. doi: 10.1038/sj.bdj.2009.560.
    1. Dhillon JK, Kalra G. Cone beam computed tomography: an innovative tool in pediatric dentistry. J Pediatr Dent. 2013;1(02):27. doi: 10.4103/WKMP-0028.117440.
    1. De Moraes ME, Hollender LG, Chen CS, et al. Evaluating craniofacial asymmetry with digital cephalometric images and cone-beam computed tomography. Am J Orthod Dentofacial Orthop. 2011;139(06):e523–531. doi: 10.1016/j.ajodo.2010.10.020.
    1. Cevidanes LH, Oliveira AE, Grauer D, et al. Clinical application of 3D imaging for assessment of treatment outcomes. Semin Orthod. 2011;17(01):72–80. doi: 10.1053/j.sodo.2010.08.012. WBSaunders.
    1. Damstra J, Fourie Z, Ren Y. Comparison between two-dimensional and midsagittal three dimensional cephalometric measurements of dry human skulls. Br J Oral Maxillofac Surg. 2011;49(05):392–395. doi: 10.1016/j.bjoms.2010.06.006.
    1. Gribel BF, Gribel MN, Manzi FR, et al. From 2D to 3D: an algorithm to derive normal values for 3-dimensional computerized assessment. Angle Orthod. 2011;81(01):3–10. doi: 10.2319/032910-173.1.
    1. Fuyamada M, Nawa H, Shibata M, et al. Reproducibility of landmark identification in the jaw and teeth on 3-dimensional cone-beam computed tomography images: a preliminary study oftentative methods compared to those based on cephalometric definitions. Angle Orthod. 2011;81(05):843–849. doi: 10.2319/010711-5.1.
    1. Rossini G, Cavallini C, Cassetta M, et al. 3D cephalometric analysis obtained from computed tomography. Review of the literature. Ann Stomatol (Roma) 2011;2(3–4):31.
    1. Schlicher W, Nielsen I, Huang JC, et al. Consistency and precision of landmark identification in three dimensiona lcone beam computed tomography scans. Eur J Orthod. 2012;34(03):263–275. doi: 10.1093/ejo/cjq144.
    1. Tarazona B, Llamas JM, Cibrian R, et al. A comparison between dental measurements taken from CBCT models and those taken from a digital method. Eur J Orthod. 2013;35(01):1–6. doi: 10.1093/ejo/cjr005.
    1. Holan G, Eidelman E, Fuks AB. Long-term evaluation of pulpotomy in primary molars using mineral trioxide aggregate or formocresol. Pediatr Dent. 2005;27(02):129–136.
    1. Sushynski JM, Zealand CM, Botero TM, et al. Comparison of gray mineral trioxide aggregate and diluted formocresol in pulpotomized primary molars: a 6-to 24-month observation. Pediatr Dent. 2012;34(05):120–128. ;
    1. Doyle WA. Formocresol versus calcium hydroxide in pulpotomy. J Den Child. 1962;29:86–97. doi: 10.1177/00220345650440050401.
    1. Duarte MA, Demarchi AC, Yamashita JC, et al. pH and calcium ion release of 2 root-end filling materials. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(03):345–347. doi: 10.1067/moe.2003.12.
    1. Monteiro Bramante C, Demarchi AC, de Moraes IG, et al. Presence of arsenic in different types of MTA and white and gray Portland cement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(06):909–913. doi: 10.1016/j.tripleo.2008.07.018.
    1. Camilleri J. Characterization of hydration products of mineral trioxide aggregate. Int Endod J. 2008;41(05):408–417. doi: 10.1111/j.1365-2591.2007.01370.x.
    1. Torabinejad M, Parirokh M, Dummer PM. Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview–part II: other clinical applications and complications. Int Endod J. 2018;51(03):284–317. doi: 10.1111/iej.12843.
    1. Okamoto Y, Sonoyama W, Ono M, et al. Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo. J Endod. 2009;35(03):367–372. doi: 10.1016/j.joen.2008.11.024.
    1. Jung IY, Lee SJ, Hargreaves KM. Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series. J Endod. 2008;34(07):876–887. doi: 10.1016/j.joen.2008.03.023.
    1. Aminabadi NA, Huang B, Samiei M, et al. A randomized trial using 3Mixtatin compared to MTA in primary molars with inflammatory root resorption: a novel endodontic biomaterial. J Clin Pediatr Dent. 2016;40(02):95–102. doi: 10.17796/1053-4628-40.2.95.
    1. Aminabadi NA, Satrab S, Najafpour E, et al. A randomized trial of direct pulp capping in primary molars using MTA compared to 3Mixtatin: a novel pulp capping biomaterial. Int J Paediatr Dent. 2016;26(04):281–290. doi: 10.1111/ipd.12196.
    1. Gruythuysen RJ, Weerheijm KL. Calcium hydroxide pulpotomy with a light-cured cavity-sealing material after two years. ASDC J Dent Child. 1997;64(04):251–253.

Source: PubMed

Спонсоры и соавторы

Заболевания

Медикаментозные вмешательства

Подписаться