Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease

B E Damato, D Allan, S B Murray, W R Lee, B E Damato, D Allan, S B Murray, W R Lee

Abstract

Histological examination of 99 human lacrimal glands showed a relationship between atrophy of the secretory acini and secretory duct obstruction, ascending periductal fibrosis, and obliteration of the adjacent blood vessels caused by lymphocytic and polymorphonuclear inflammation. Investigation of the subgroups of the B lymphocytic series by immunohistochemistry did not show any statistical change with age, sex, fibrosis, or lymphocytic inflammation. The concept of senile atrophy occurring as a result of senescent involution of the lacrimal gland is challenged on the basis of the histological findings.

References

    1. Acta Ophthalmol (Copenh). 1965;43(4):567-73
    1. Medicine (Baltimore). 1965 May;44:187-231
    1. J Clin Pathol. 1970 Nov;23(8):690-4
    1. Age Ageing. 1972 Nov;1(4):197-206
    1. Br J Ophthalmol. 1973 Nov;57(11):852-8
    1. J Clin Pathol. 1974 Jul;27(7):548-57
    1. Ann Intern Med. 1975 Mar;82(3):405-10
    1. Acta Ophthalmol (Copenh). 1978 Jun;56(3):439-44
    1. N Engl J Med. 1979 Oct 4;301(14):761-3
    1. J Clin Invest. 1980 Feb;65(2):519-28
    1. Arch Ophthalmol. 1980 Jul;98(7):1211-3
    1. Trans Ophthalmol Soc U K. 1980 Apr;100(Pt 1):96-7
    1. Arthritis Rheum. 1982 Feb;25(2):156-60
    1. Br Med J. 1951 May 26;1(4716):1183-5
    1. Trans Opthal Soc U K. 1955;75:101-19
    1. Trans Opthal Soc U K. 1955;75:435-52
    1. J Pathol Bacteriol. 1966 Jan;91(1):53-64

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