SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER)-pilot: A feasibility study

Kimberly Ann Chew, Xin Xu, Paula Siongco, Steven Villaraza, April Ka Sin Phua, Zi Xuen Wong, Chooi Yu Chung, Ning Tang, Effie Chew, Christiani Jeyakumar Henry, Edward Koo, Christopher Chen, Kimberly Ann Chew, Xin Xu, Paula Siongco, Steven Villaraza, April Ka Sin Phua, Zi Xuen Wong, Chooi Yu Chung, Ning Tang, Effie Chew, Christiani Jeyakumar Henry, Edward Koo, Christopher Chen

Abstract

Introduction: The SINGER pilot randomized controlled trial aims to examine the feasibility and acceptability of the Finnish Geriatric Intervention Study (FINGER) multi-domain lifestyle interventions compared to Singaporean adaptations.

Methods: Seventy elderly participants were recruited and randomized into FINGER (n = 36) or SINGER (n = 34) interventions; involving physical exercise, cognitive training, diet, and vascular risk factors management, for 6 months.

Results: Both intervention groups were equally feasible and acceptable with participants completing at least 80% of the interventions. Body strength improved in both groups (Pupper body = .04, P lower body = .06, P core = .05). More participants in the SINGER group attained good blood pressure control at month-6 compared to FINGER (41% vs 19%; P = .06).

Discussion: This study is the first to compare the feasibility of multi-domain interventions adapted to local culture with the FINGER interventions. The findings will be utilized for a larger study to provide evidence for the efficacy of multi-domain lifestyle interventions in preventing cognitive decline.

Keywords: cognitive impairment; dementia; feasibility; intervention; lifestyle; randomized controlled trial.

Conflict of interest statement

None declared.

© 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.

Figures

FIGURE 1
FIGURE 1
Recruitment flowchart
FIGURE 2
FIGURE 2
Timeline of study period affected by the COVID‐19 pandemic
FIGURE 3
FIGURE 3
Overall BP outcome between groups

References

    1. World Health Organisation . Dementia. World Health Organisation; 2019. . Accessed August 7, 2020.
    1. Fulop T, Larbi A, Witkowski JM, et al. Aging, frailty and age‐related diseases. Biogerontology. 2010;11(5):547‐563.
    1. Chen C, Xu X, Chew E, Henry CJ, Koo EH. Singapore intervention study to prevent cognitive impairment and disability (singer) initiative. Alzheimers Dement. 2017;13(7).
    1. United Nations, Department of Economic and Social Affairs, Population Division. New York: United Nations: World Population Ageing; 2019. (ST/ESA/SER.A/444)
    1. Klimova B, Valis M, Kuca K. Cognitive decline in normal aging and its prevention: a review on non‐pharmacological lifestyle strategies. Clin Interv Aging. 2017;12:903‐910.
    1. Moll van Charante E, Richard E, Eurelings LS, et al. Effectiveness of a 6‐year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster‐randomized controlled trial. Lancet. 2016;388:797‐805.
    1. Andrieu S, Guyonnet, S , Coley, N , et al. Effect of long‐term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomized, placebo‐controlled trial. Neurol. 2017;16:377‐389.
    1. Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at‐risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255‐2263.
    1. Kivipelto M, Mangialasche F, Snyder HM, et al. World‐wide FINGERS network: a global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020;16(7):1078‐1094.
    1. Lusardi MM, Pellecchia GL, Schulman M. Functional performance in community living older adults. J Geriatr Phy Ther. 2003;26(3):14‐22.
    1. Ministry of Health Singapore. Hypertension: MOH Clinical Practice Guidelines 01/2017. . Accessed August 7, 2020.
    1. SPRINT . Systolic Blood Pressure Intervention Trial. SPRINT Version 4.0. 2012.
    1. The SPRINT research group. A randomized trial of intensive versus standard blood‐pressure control. N Engl J Med. 2015;373:2103‐2116.
    1. Shen JHQ, Shen, Q , Yu, H , et al. Validation of an Alzheimer's disease assessment battery in Asian participants with mild to moderate Alzheimer's disease. Am J Neurodegener Dis 2014;3(3):158‐169.
    1. Sayers SP, Jette AM, Haley SM, et al. Validation of the late‐life function and disability instrument. J Am Geriatr Soc. 2004;52(9):1554‐1559.
    1. Ng TP, Ling LHA, Feng L, et al. Cognitive effects of multi‐domain interventions among pre‐frail and frail community‐living older persons: randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2018;73(6):806‐812.
    1. Malhotra R, Chan A, Malhotra C, Østbye T. Prevalence, awareness, treatment and control of hypertension in the elderly population of Singapore. Hypertens Res. 2010;33:1223‐1231.
    1. The SPRINT MIND investigators for the SPRINT research group. Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial. JAMA. 2019;321(6):553‐561.
    1. Blumenthal JA, Smith PJ, Mabe S, et al. Lifestyle and neurocognition in older adults with cognitive impairments: a randomized trial. Neurol. 2019;92(3):e212‐e223.
    1. Yusuf S, Joseph P, Rangarajan S, et al. Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high‐income, middle‐income, and low‐income countries (PURE): a prospective cohort study. Lancet. 2020;395:795‐808.
    1. Global burden of metabolic risk factors for chronic diseases collaboration. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Lancet Diabetes Endocrinol. 2014;2:634‐647.

Source: PubMed

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