Efficacy and safety of 1565-nm non-ablative fractional laser versus long-pulsed 1064-nm Nd:YAG laser in treating enlarged facial pores

Ying Wang, Yuxin Zheng, Suiqing Cai, Ying Wang, Yuxin Zheng, Suiqing Cai

Abstract

Facial pores are visible openings of pilosebaceous follicles, and they are one of the major factors influencing facial skin appearance. This article aims to evaluate and compare the efficacy and safety of 1565-nm non-ablative fractional laser (NAFL) and long-pulsed 1064-nm Nd:YAG laser (LPNY) in treating enlarged facial pores. All subjects were treated with NAFL on their left faces and LPNY on their right. Five treatments were administered at 2-week intervals, with one follow-up session 2 months after the final treatment. Treatment efficacy was evaluated by subjective (pore improvement and subject satisfaction ratings) assessments and objective (pore number) assessments. At each appointment, any side effects or complications were recorded to evaluate the safety of the two lasers. A total of 18 individuals participated in this study. At the 2-month follow-up, NAFL and LPNY sides had significant reduction in pores (p < 0.0001 and p < 0.0001, respectively). However, there was no statistically significant difference in the mean number of pore reductions on either side (p > 0.05). There was no significant difference in pore improvement ratings and satisfaction ratings between the two sides (p > 0.05 and p > 0.05, respectively). Both lasers showed minimal side effects. Both lasers effectively treated enlarged facial pores and were well tolerated. The side effects of the 1064-nm LPNY were less severe than those of the 1565-nm NAFL. ClinicalTrial.gov Identifier: NCT05360043.

Keywords: Enlarged facial pores; Long-pulsed Nd:YAG laser; Non-ablative fractional laser.

Conflict of interest statement

The authors declare no competing interests.

© 2022. The Author(s).

Figures

Fig. 1
Fig. 1
Average VISIA pore counts from baseline through 2-month follow-up visit (2 M FU). N = 18. Tx, treatment. NAFL, 1565-nm non-ablative fractional laser; LPNY, long-pulsed 1064-nm Nd:YAG laser
Fig. 2
Fig. 2
Split-face comparison of pores of a 25-year-old woman at baseline and 2-month follow-up visit with the VISIA system, highlighting the pores available for counting. a LPNY-treated side at baseline. b NAFL-treated side at baseline. c LPNY-treated side at 2-month follow-up, pore number decreased by 28.9% compared to baseline. d NAFL-treated side at 2-month follow-up, pore number decreased by 43% compared to baseline. NAFL, 1565-nm non-ablative fractional laser; LPNY, long-pulsed 1064-nm Nd:YAG laser
Fig. 3
Fig. 3
Pores of a 36-year-old woman pretreatment and at a 2-month follow-up visit after five treatments with the VISIA system. a LPNY-treated side at baseline. b NAFL-treated side at baseline. c LPNY-treated side at 2-month follow-up. d NAFL-treated side at 2-month follow-up. Visible pores were reduced after both laser treatments. More apparent improvement of pores can be observed in NAFL-treated side. NAFL, 1565-nm non-ablative fractional laser; LPNY, long-pulsed 1064-nm Nd:YAG laser
Fig. 4
Fig. 4
Subjective assessments. Participants rated improvement in appearance of pores after each treatment (Tx) and at 2-month follow-up (2 M FU). N = 18. Avg, average; NAFL, 1565-nm non-ablative fractional laser; LPNY, long-pulsed 1064-nm Nd:YAG laser

References

    1. Uhoda E, Pierard-Franchimont C, Petit L, Pierard GE. The conundrum of skin pores in dermocosmetology. Dermatol. 2005;210(1):3–7. doi: 10.1159/000081474.
    1. Phillips TJ, Gottlieb AB, Leyden JJ, Lowe NJ, Lew-Kaya DA, Sefton J, et al. Efficacy of 0.1% tazarotene cream for the treatment of photodamage :a 12-month multicenter, randomized trial. Arch Dermatol . 2002;138(11):1486–93. doi: 10.1001/archderm.138.11.1486.
    1. Hernandez-Perez E, Khawaja HA, Alvarez TYM. Oral isotretinoin as part of the treatment of cutaneous aging. Dermatol Surg. 2000;26(7):649–52 . doi: 10.1046/j.1524-4725.2000.99210.x.
    1. Barros B, Thiboutot D. Hormonal therapies for acne. Clin Dermatol. 2017;35(2):168–72. doi: 10.1016/j.clindermatol.2016.10.009.
    1. Rose AE, Goldberg DJ. Safety and efficacy of intradermal injection of botulinum toxin for the treatment of oily skin. Dermatol Surg. 2013;39(3 Pt 1):443–448. doi: 10.1111/dsu.12097.
    1. Kakudo N, Kushida S, Tanaka N, Minakata T, Suzuki K, Kusumoto K. A novel method to measure conspicuous facial pores using computer analysis of digital-camera-captured images: the effect of glycolic acid chemical peeling. Skin Res Technol. 2011;17(4):427–433. doi: 10.1111/j.1600-0846.2011.00514.x.
    1. Lee SJ, Seok J, Jeong SY, Park KY, Li K, Seo SJ. Facial pores: definition, causes, and treatment options. Dermatol Surg. 2016;42(3):277–285. doi: 10.1097/DSS.0000000000000657.
    1. Hong JS, Park SY, Seo KK, Goo BL, Hwang EJ, Park GY, et al. Long pulsed 1064 nm Nd:YAG laser treatment for wrinkle reduction and skin laxity: evaluation of new parameters. Int J Dermatol. 2015;54(9):e345–e350. doi: 10.1111/ijd.12626.
    1. Lee YB, Shin JY, Cheon MS, Oh ST, Cho BK, Park HJ. Photorejuvenation using long-pulsed alexandrite and long-pulsed neodymium:yttrium-aluminum-garnet lasers: a pilot study of clinical outcome and patients’ satisfaction in Koreans. J Dermatol. 2012;39(5):425–429. doi: 10.1111/j.1346-8138.2011.01465.x.
    1. Taylor MB, Prokopenko I. Split-face comparison of radiofrequency versus long-pulse Nd-YAG treatment of facial laxity. J Cosmet Laser Ther. 2006;8(1):17–22. doi: 10.1080/14764170600607285.
    1. Roh MR, Chung HJ, Chung KY. Effects of various parameters of the 1064 nm Nd:YAG laser for the treatment of enlarged facial pores. J Dermatolog Treat. 2009;20(4):223–8. doi: 10.1080/09546630802647244.
    1. Wattanakrai P, Rojhirunsakool S, Pootongkam S. Split-face comparison of long-pulse-duration neodymium-doped yttrium aluminum garnet (Nd:YAG) 1,064-nm laser alone and combination long-pulse and Q-switched Nd:YAG 1,064-nm laser with carbon photoenhancer lotion for the treatment of enlarged pores in Asian women. Dermatol Surg. 2010;36(11):1672–80. doi: 10.1111/j.1524-4725.2010.01717.x.
    1. Yu W, Zhu J, Ma G, Yang J, Qiu Y, Chen Y, et al. Randomized split-face, controlled comparison of treatment with 1565-nm nonablative fractional laser for enlarged facial pores. Br J Dermatol. 2018;178(4):e271–e2. doi: 10.1111/bjd.16115.
    1. Jung JY, Cho SB, Chung HJ, Shin JU, Lee KH, Chung KY. Treatment of periorbital wrinkles with 1550- and 1565-nm Er:glass fractional photothermolysis lasers: a simultaneous split-face trial. J Eur Acad Dermatol Venereol. 2011;25(7):811–818. doi: 10.1111/j.1468-3083.2010.03870.x.
    1. Schmults CD, Phelps R, Goldberg DJ. Nonablative facial remodeling: erythema reduction and histologic evidence of new collagen formation using a 300-microsecond 1064-nm Nd:YAG laser. Arch Dermatol. 2004;140(11):1373–1376. doi: 10.1001/archderm.140.11.1373.
    1. Dayan S, Damrose JF, Bhattacharyya TK, Mobley SR, Patel MK, O'Grady K, et al. Histological evaluations following 1,064-nm Nd:YAG laser resurfacing. Lasers Surg Med. 2003;33(2):126–31. doi: 10.1002/lsm.10194.
    1. Kim M, Kim J, Jeong SW, Jo H, Park HJ. Long-pulsed 1064-nm Nd: YAG laser ameliorates LL-37-induced rosacea-like skin lesions through promoting collagen remodeling in BALB/c mice. Lasers Med Sci. 2018;33(2):393–397. doi: 10.1007/s10103-017-2410-8.
    1. Sadick NS. Update on non-ablative light therapy for rejuvenation: a review. Lasers Surg Med. 2003;32(2):120–128. doi: 10.1002/lsm.10127.
    1. Dang YY, Ren QS, Liu HX, Ma JB, Zhang JS. Comparison of histologic, biochemical, and mechanical properties of murine skin treated with the 1064-nm and 1320-nm Nd:YAG lasers. Exp Dermatol. 2005;14(12):876–882. doi: 10.1111/j.1600-0625.2005.00371.x.
    1. Roh M, Goo B, Jung J, Chung H, Chung K. Treatment of enlarged pores with the quasi long-pulsed versus Q-switched 1064 nm Nd:YAG lasers: a split-face, comparative, controlled study. Laser Ther. 2011;20(3):175–80. doi: 10.5978/islsm.20.175.
    1. Zaleski-Larsen LA, Jones IT, Guiha I, Wu DC, Goldman MP. A comparison study of the nonablative fractional 1565-nm Er: glass and the picosecond fractional 1064/532-nm Nd: YAG lasers in the treatment of striae alba: a split body double-blinded trial. Dermatol Surg. 2018;44(10):1311–1316. doi: 10.1097/DSS.0000000000001555.
    1. Guertler A, Reinholz M, Poetschke J, Steckmeier S, Schwaiger H, Gauglitz GG. Objective evaluation of the efficacy of a non-ablative fractional 1565 nm laser for the treatment of deliberate self-harm scars. Lasers Med Sci. 2017;33(2):241–250. doi: 10.1007/s10103-017-2348-x.
    1. Munavalli G. A split-face assessment of the synergistic potential of sequential Q-switched Nd:YAG laser and 1565 nm fractional nonablative laser treatment for facial rejuvenation in Fitzpatrick skin type II-V patients. J Drugs Dermatol. 2016;15(11):1335–1342.

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