A 6MWT index to predict O2 flow correcting exercise induced SpO2 desaturation in ILD
Josuel Ora, Luigino Calzetta, Gabriella Pezzuto, Lucia Senis, Gregorino Paone, Alessia Mari, Silvia Portalone, Paola Rogliani, Ermanno Puxeddu, Cesare Saltini, Josuel Ora, Luigino Calzetta, Gabriella Pezzuto, Lucia Senis, Gregorino Paone, Alessia Mari, Silvia Portalone, Paola Rogliani, Ermanno Puxeddu, Cesare Saltini
Abstract
Introduction: Ambulatory oxygen (O2) is prescribed to interstitial lung disease (ILD) patients with mild hypoxemia, breathlessness and dyspnea on exertion. Oxygen titration is generally done with the 6 minute walk test (6MWT) to determine the O2 flow preventing oxygen saturation by pulse oximetry (SpO2) from falling below 88%. His study was designed to generate a 6MWT index predicting the O2 flow allowing completion of the 6MWT without oxygen desaturation.
Methods: Oxygen titration data from a group of 66 ILD patients and 30 controls, were used to generate the algorithm determining an index (O2-GAP) predicting oxygen flow required to complete a 6MWT without desaturation below 88%. This index was validated in a group of 93 ILD patients.
Results: The O2-GAP index, as obtained from the derivation population, (r(2) = 0.97, p < 0.001) was shown to correctly predict the oxygen flow required to complete the 6MWT without SpO2 falling below 88% validated in the validation population (r(2) = 0.842; p < 0.001).
Conclusions: The O2-GAP index appears to be a useful tool to titrate ambulatory O2 with a single 6MWT on room air in ILD patients with breathlessness and dyspnea on exertion.
Keywords: 6-min walk test; Exercise testing; Interstitial lung disease; Oxygen therapy.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Source: PubMed