Clinical Correlates of Functional Motor Disorders: An Italian Multicenter Study

Michele Tinazzi, Francesca Morgante, Enrico Marcuzzo, Roberto Erro, Paolo Barone, Roberto Ceravolo, Sonia Mazzucchi, Andrea Pilotto, Alessandro Padovani, Luigi M Romito, Roberto Eleopra, Mario Zappia, Alessandra Nicoletti, Carlo Dallocchio, Carla Arbasino, Francesco Bono, Angelo Pascarella, Benedetta Demartini, Orsola Gambini, Nicola Modugno, Enrica Olivola, Vincenzo Di Stefano, Alberto Albanese, Gina Ferrazzano, Alessandro Tessitore, Maurizio Zibetti, Giovanna Calandra-Buonaura, Martina Petracca, Marcello Esposito, Antonio Pisani, Paolo Manganotti, Fabrizio Stocchi, Mario Coletti Moja, Angelo Antonini, Giovanni Defazio, Christian Geroin, Michele Tinazzi, Francesca Morgante, Enrico Marcuzzo, Roberto Erro, Paolo Barone, Roberto Ceravolo, Sonia Mazzucchi, Andrea Pilotto, Alessandro Padovani, Luigi M Romito, Roberto Eleopra, Mario Zappia, Alessandra Nicoletti, Carlo Dallocchio, Carla Arbasino, Francesco Bono, Angelo Pascarella, Benedetta Demartini, Orsola Gambini, Nicola Modugno, Enrica Olivola, Vincenzo Di Stefano, Alberto Albanese, Gina Ferrazzano, Alessandro Tessitore, Maurizio Zibetti, Giovanna Calandra-Buonaura, Martina Petracca, Marcello Esposito, Antonio Pisani, Paolo Manganotti, Fabrizio Stocchi, Mario Coletti Moja, Angelo Antonini, Giovanni Defazio, Christian Geroin

Abstract

Background: Functional motor disorders (FMDs) are abnormal movements that are significantly altered by distractive maneuvers and are incongruent with movement disorders seen in typical neurological diseases.

Objective: The objectives of this article are to (1) describe the clinical manifestations of FMDs, including nonmotor symptoms and occurrence of other functional neurological disorders (FND); and (2) to report the frequency of isolated and combined FMDs and their relationship with demographic and clinical variables.

Methods: For this multicenter, observational study, we enrolled consecutive outpatients with a definite diagnosis of FMDs attending 25 tertiary movement disorders centers in Italy. Each patient underwent a detailed clinical evaluation with a definition of the phenotype and number of FMDs (isolated, combined) and an assessment of associated neurological and psychiatric symptoms.

Results: Of 410 FMDs (71% females; mean age, 47 ± 16.1 years) the most common phenotypes were weakness and tremor. People with FMDs had higher educational levels than the general population and frequent nonmotor symptoms, especially anxiety, fatigue, and pain. Almost half of the patients with FMDs had other FNDs, such as sensory symptoms, nonepileptic seizures, and visual symptoms. Patients with combined FMDs showed a higher burden of nonmotor symptoms and more frequent FNDs. Multivariate regression analysis showed that a diagnosis of combined FMDs was more likely to be delivered by a movement disorders neurologist. Also, FMD duration, pain, insomnia, diagnosis of somatoform disease, and treatment with antipsychotics were all significantly associated with combined FMDs.

Conclusions: Our findings highlight the need for multidimensional assessments in patients with FMDs given the high frequency of nonmotor symptoms and other FNDs, especially in patients with combined FMDs.

Keywords: functional neurological disorders, functional dystonia, functional tremor, functional weakness, diagnosis.

Conflict of interest statement

The authors declare that there are no conflicts of interest to report.

© 2020 International Parkinson and Movement Disorder Society.

Figures

FIG. 1
FIG. 1
Education levels in the Italian population aged > 6 years (reference year, 2011) and the Italian Registry of FMDs population (age range 10–85) (total sample is 364; 46 missing values). FMDs, functional motor disorders.
FIG. 2
FIG. 2
Clinical symptoms reported in patients with FMDs; patients can have 1 FMD (isolated; eg, only tremor or weakness) or more FMDs (eg, weakness + tremor + gait disorders). (A) The different FMD phenomenologies and their body distribution. (B) Patient self‐reported nonmotor symptoms and other FNDs. The bar represents the percentage, whereas the number above shows the absolute value. FMDs, functional motor disorders; FND, functional neurological disorder; FS, functional symptoms; PNES, nonepileptic seizures.

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Source: PubMed

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