Involvement of ICU families in decisions: fine-tuning the partnership

Elie Azoulay, Marine Chaize, Nancy Kentish-Barnes, Elie Azoulay, Marine Chaize, Nancy Kentish-Barnes

Abstract

Families of patients are not simple visitors to the ICU. They have just been separated from a loved one, often someone they live with, either abruptly or, in nearly half the cases, because a chronic condition has suddenly worsened. They must cope with a serious illness of a loved one, while having to adapt to the unfamiliar and intimidating ICU environment. In many cases, the outcome of the critical illness is uncertain, a situation that causes considerable distress to the relatives. As shown by our research group and others, families exhibit symptoms of anxiety (70%) and depression (35%) in the first few days after admission, as well as symptoms of stress (33%) and difficulty understanding the information delivered by the healthcare staff (50%). Furthermore, relatives of patients who die in the ICU are at risk for psychiatric syndromes such as generalized anxiety, panic attacks, depression, and posttraumatic stress syndrome. In this setting of psychological distress, families are asked to consider sharing in healthcare decisions about their loved one in the ICU. This article aims to foster the debate about the shared decision-making process. We have three objectives: to transcend the overly simplistic position that opposes paternalism and autonomy, to build a view founded only on an evaluation of actual practice and experience in the field, and to keep the focus squarely on the patient. Families want information and communication time from the staff. Nurses and physicians need to understand that families can share in decisions only if the entire ICU staff actively promotes family involvement and, of course, if the family wants to participate in all or part of the decision-making process.

Keywords: Bereavement; Communication; End of life; Information; Randomized controlled trials.

References

    1. Cassell EJ, Leon AC, Kaufman SG. Preliminary evidence of impaired thinking in sick patients. Ann Intern Med. 2001;134:1120–1123. doi: 10.7326/0003-4819-134-12-200106190-00012.
    1. Ferrand E, Bachoud-Levi AC, Rodrigues M, Maggiore S, Brun-Buisson C, Lemaire F. Decision-making capacity and surrogate designation in French ICU patients. Intensive Care Med. 2001;27:1360–1364. doi: 10.1007/s001340100982.
    1. Long AC, Kross EK, Engelberg RA, Downey L, Nielsen EL, Back AL, Curtis JR: Quality of dying in the ICU: is it worse for patients admitted from the hospital ward compared to those admitted from the emergency department?Intensive Care Med 2014, 2014:13.
    1. Upadya A, Muralidharan V, Thorevska N, Amoateng-Adjepong Y, Manthous CA. Patient, physician, and family member understanding of living wills. Am J Respir Crit Care Med. 2002;166:1430–1435. doi: 10.1164/rccm.200206-503OC.
    1. Azoulay E, Cattaneo I, Ferrand E, Pochard F. L'Information au patient de Réanimation et à ses proches: le point de vue de la SRLF. Reanimation. 2001;10:571–581. doi: 10.1016/S1164-6756(01)00120-7.
    1. Azoulay E, Pochard F. Communication with family members of patients dying in the intensive care unit. Curr Opin Crit Care. 2003;9:545–550. doi: 10.1097/00075198-200312000-00014.
    1. Azoulay E, Pochard F, Chevret S, Adrie C, Annane D, Bleichner G, Bornstain C, Bouffard Y, Cohen Y, Feissel M, Goldgran-Toledano D, Guitton C, Hayon J, Iglesias E, Joly LM, Jourdain M, Laplace C, Lebert C, Pingat J, Poisson C, Renault A, Sanchez O, Selcer D, Timsit JF, Le Gall JR. Schlemmer B; FAMIREA Study Group: Half the family members of intensive care unit patients do not want to share in the decision-making process: a study in 78 French intensive care units. Crit Care Med. 2004;32:1832–1838. doi: 10.1097/01.CCM.0000139693.88931.59.
    1. Azoulay E, Pochard F, Chevret S, Arich C, Brivet F, Brun F, Charles PE, Desmettre T, Dubois D, Galliot R, Garrouste-Orgeas M, Goldgran-Toledano D, Herbecq P, Joly LM, Jourdain M, Kaidomar M, Lepape A, Letellier N, Marie O, Page B, Parrot A, Rodie-Talbere PA, Sermet A, Tenaillon A, Thuong M, Tulasne P, Le Gall JR, Schlemmer B. Family participation in care to the critically ill: opinions of families and staff. Intensive Care Med. 2003;29:1498–1504. doi: 10.1007/s00134-003-1904-y. Epub 2003 Jul 1410.
    1. Bouju P, Tadie JM, Uhel F, Letheulle J, Fillatre P, Lavoue S, Camus C, Le Tulzo Y, Gacouin A. Internet use by family members of intensive care unit patients: a pilot study. Intensive Care Med. 2014;40:1175–1176. doi: 10.1007/s00134-014-3371-z.
    1. Prendergast T. Research agenda or (North) American cultural hegemony? Crit Care Med. 2001;29:2024–2025. doi: 10.1097/00003246-200110000-00030.
    1. Sprung CL, Cohen SL, Sjokvist P, Baras M, Bulow HH, Hovilehto S, Ledoux D, Lippert A, Maia P, Phelan D, Schobersberger W, Wennberg E, Woodcock T. End-of-life practices in European intensive care units: the Ethicus study. Jama. 2003;290:790–797. doi: 10.1001/jama.290.6.790.
    1. Barnato AE, Tate JA, Rodriguez KL, Zickmund SL, Arnold RM. Norms of decision making in the ICU: a case study of two academic medical centers at the extremes of end-of-life treatment intensity. Intensive Care Med. 2012;38:1886–1896. doi: 10.1007/s00134-012-2661-6.
    1. Bulow HH, Sprung CL, Baras M, Carmel S, Svantesson M, Benbenishty J, Maia PA, Beishuizen A, Cohen S, Nalos D. Are religion and religiosity important to end-of-life decisions and patient autonomy in the ICU? The Ethicatt study. Intensive Care Med. 2012;38:1126–1133. doi: 10.1007/s00134-012-2554-8.
    1. Azoulay E, Sprung CL. Family-physician interactions in the intensive care unit. Crit Care Med. 2004;32:2323–2328.
    1. Cook D. Patient autonomy versus parentalism. Crit Care Med. 2001;29:N24–N25. doi: 10.1097/00003246-200102001-00005.
    1. Chassin MR, Brook RH, Park RE, Keesey J, Fink A, Kosecoff J, Kahn K, Merrick N, Solomon DH. Variations in the use of medical and surgical services by the Medicare population. N Engl J Med. 1986;314:285–290. doi: 10.1056/NEJM198601303140505.
    1. Forte DN, Vincent JL, Velasco IT, Park M. Association between education in EOL care and variability in EOL practice: a survey of ICU physicians. Intensive Care Med. 2012;38:404–412. doi: 10.1007/s00134-011-2400-4.
    1. Azoulay E, Chevret S, Leleu G, Pochard F, Barboteu M, Adrie C, Canoui P, Le Gall JR, Schlemmer B. Half the families of intensive care unit patients experience inadequate communication with physicians. Crit Care Med. 2000;28:3044–3049. doi: 10.1097/00003246-200008000-00061.
    1. Rodriguez RM, Navarrete E, Schwaber J, McKleroy W, Clouse A, Kerrigan SF, Fortman J. A prospective study of primary surrogate decision makers' knowledge of intensive care. Crit Care Med. 2008;36:1633–1636. doi: 10.1097/CCM.0b013e31816a0784.
    1. Verceles AC, Corwin DS, Afshar M, Friedman EB, McCurdy MT, Shanholtz C, Oakjones K, Zubrow MT, Titus J, Netzer G. Half of the family members of critically ill patients experience excessive daytime sleepiness. Intensive Care Med. 2014;40:1124–1131. doi: 10.1007/s00134-014-3347-z.
    1. Zier LS, Sottile PD, Hong SY, Weissfield LA, White DB. Surrogate decision makers' interpretation of prognostic information: a mixed-methods study. Ann Intern Med. 2012;156:360–366. doi: 10.7326/0003-4819-156-5-201203060-00008.
    1. White DB, Cua SM, Walk R, Pollice L, Weissfeld L, Hong S, Landefeld CS, Arnold RM. Nurse-led intervention to improve surrogate decision making for patients with advanced critical illness. Am J Crit Care. 2012;21:396–409. doi: 10.4037/ajcc2012223.
    1. Scheunemann LP, Arnold RM, White DB. The facilitated values history: helping surrogates make authentic decisions for incapacitated patients with advanced illness. Am J Respir Crit Care Med. 2012;186:480–486. doi: 10.1164/rccm.201204-0710CP.
    1. Schenker Y, Crowley-Matoka M, Dohan D, Tiver GA, Arnold RM, White DB. I don't want to be the one saying 'we should just let him die': intrapersonal tensions experienced by surrogate decision makers in the ICU. J Gen Intern Med. 2012;27(12):1657–1665. doi: 10.1007/s11606-012-2129-y.
    1. Murray E, Charles C, Gafni A. Shared decision-making in primary care: tailoring the Charles et al. model to fit the context of general practice. Patient Educ Couns. 2006;62:205–211. doi: 10.1016/j.pec.2005.07.003.
    1. Carlet J, Thijs LG, Antonelli M, Cassell J, Cox P, Hill N, Hinds C, Pimentel JM, Reinhart K, Thompson BT. Challenges in end-of-life care in the ICU. Statement of the 5th international consensus conference in critical care: Brussels, Belgium, April 2003. Intensive Care Med. 2004;30:770–784. doi: 10.1007/s00134-004-2241-5. Epub 2004 Apr 2020.
    1. Curtis JR, Patrick DL, Shannon SE, Treece PD, Engelberg RA, Rubenfeld GD. The family conference as a focus to improve communication about end-of-life care in the intensive care unit: opportunities for improvement. Crit Care Med. 2001;29:N26–N33. doi: 10.1097/00003246-200102001-00006.
    1. Curtis JR, White DB. Practical guidance for evidence-based ICU family conferences. Chest. 2008;134:835–843. doi: 10.1378/chest.08-0235.
    1. Lautrette A, Ciroldi M, Ksibi H, Azoulay E. End-of-life family conferences: rooted in the evidence. Crit Care Med. 2006;34:S364–S372. doi: 10.1097/01.CCM.0000237049.44246.8C.
    1. White DB, Braddock CH 3rd, Bereknyei S, Curtis JR. Toward shared decision making at the end of life in intensive care units: opportunities for improvement. Arch Intern Med. 2007;167:461–467. doi: 10.1001/archinte.167.5.461.
    1. Schwab AP. Formal and effective autonomy in healthcare. J Med Ethics. 2006;32:575–579. doi: 10.1136/jme.2005.013391.
    1. Heyland DK, Rocker GM, Dodek PM, Kutsogiannis DJ, Konopad E, Cook DJ, Peters S, Tranmer JE, O'Callaghan CJ. Family satisfaction with care in the intensive care unit: results of a multiple center study. Crit Care Med. 2002;30:1413–1418. doi: 10.1097/00003246-200207000-00002.
    1. Heyland DK, Tranmer JE. Measuring family satisfaction with care in the intensive care unit: the development of a questionnaire and preliminary results. J Crit Care. 2001;16:142–149. doi: 10.1053/jcrc.2001.30163.
    1. Wasser T, Pasquale MA, Matchett SC, Bryan Y, Pasquale M. Establishing reliability and validity of the critical care family satisfaction survey. Crit Care Med. 2001;29:192–196. doi: 10.1097/00003246-200101000-00038.
    1. Azoulay E, Pochard F, Chevret S, Lemaire F, Mokhtari M, Le Gall JR, Dhainaut JF, Schlemmer B. Meeting the needs of intensive care unit patient families: a multicenter study. Am J Respir Crit Care Med. 2001;163:135–139. doi: 10.1164/ajrccm.163.1.2005117.
    1. Schleyer AM, Curtis JR. Family satisfaction in the ICU: why should ICU clinicians care? Intensive Care Med. 2013;39:1143–1145. doi: 10.1007/s00134-013-2939-3.
    1. Jongerden IP, Slooter AJ, Peelen LM, Wessels H, Ram CM, Kesecioglu J, Schneider MM, van Dijk D. Effect of intensive care environment on family and patient satisfaction: a before-after study. Intensive Care Med. 2013;39:1626–1634. doi: 10.1007/s00134-013-2966-0.
    1. Azoulay E, Pochard F, Chevret S, Adrie C, Bollaert PE, Brun F, Dreyfuss D, Garrouste-Orgeas M, Goldgran-Toledano D, Jourdain M, Wolff M, Le Gall JR, Schlemmer B. Opinions about surrogate designation: a population survey in France. Crit Care Med. 2003;31:1711–1714. doi: 10.1097/01.CCM.0000069828.15555.09.
    1. Azoulay E, Pochard F, Kentish-Barnes N, Chevret S, Aboab J, Adrie C, Annane D, Bleichner G, Bollaert PE, Darmon M, Fassier T, Galliot R, Garrouste-Orgeas M, Goulenok C, Goldgran-Toledano D, Hayon J, Jourdain M, Kaidomar M, Laplace C, Larché J, Liotier J, Papazian L, Poisson C, Reignier J, Saidi F, Schlemmer B. Risk of post-traumatic stress symptoms in family members of intensive care unit patients. Am J Respir Crit Care Med. 2005;171:987–994. doi: 10.1164/rccm.200409-1295OC. Epub 2005 Jan 2021.
    1. Pochard F, Azoulay E, Chevret S, Lemaire F, Hubert P, Canoui P, Grassin M, Zittoun R, le Gall JR, Dhainaut JF, Schlemmer B. Symptoms of anxiety and depression in family members of intensive care unit patients: ethical hypothesis regarding decision-making capacity. Crit Care Med. 2001;29:1893–1897. doi: 10.1097/00003246-200110000-00007.
    1. Pochard F, Darmon M, Fassier T, Bollaert PE, Cheval C, Coloigner M, Merouani A, Moulront S, Pigne E, Pingat J, Zahar JR, Schlemmer B, Azoulay E. Symptoms of anxiety and depression in family members of intensive care unit patients before discharge or death. A prospective multicenter study. J Crit Care. 2005;20:90–96. doi: 10.1016/j.jcrc.2004.11.004.
    1. Siegel MD, Hayes E, Vanderwerker LC, Loseth DB, Prigerson HG. Psychiatric illness in the next of kin of patients who die in the intensive care unit. Crit Care Med. 2008;36:1722–1728. doi: 10.1097/CCM.0b013e318174da72.
    1. Abbott KH, Sago JG, Breen CM, Abernethy AP, Tulsky JA. Families looking back: one year after discussion of withdrawal or withholding of life-sustaining support. Crit Care Med. 2001;29:197–201. doi: 10.1097/00003246-200101000-00040.
    1. Curtis JR, Patrick DL, Engelberg RA, Norris K, Asp C, Byock I. A measure of the quality of dying and death. Initial validation using after-death interviews with family members. J Pain Symptom Manage. 2002;24:17–31. doi: 10.1016/S0885-3924(02)00419-0.
    1. Cuthbertson SJ, Margetts MA, Streat SJ. Bereavement follow-up after critical illness. Crit Care Med. 2000;28:1196–1201. doi: 10.1097/00003246-200004000-00047.
    1. Malacrida R, Bettelini CM, Degrate A, Martinez M, Badia F, Piazza J, Vizzardi N, Wullschleger R, Rapin CH. Reasons for dissatisfaction: a survey of relatives of intensive care patients who died. Crit Care Med. 1998;26:1187–1193. doi: 10.1097/00003246-199807000-00018.
    1. Rabow MW, Hauser JM, Adams J. Supporting family caregivers at the end of life: "they don't know what they don't know". Jama. 2004;291:483–491. doi: 10.1001/jama.291.4.483.
    1. Christakis NA, Allison PD. Mortality after the hospitalization of a spouse. N Engl J Med. 2006;354:719–730. doi: 10.1056/NEJMsa050196.
    1. Azoulay E, Timsit JF, Sprung CL, Soares M, Rusinova K, Lafabrie A, Abizanda R, Svantesson M, Rubulotta F, Ricou B, Benoit D, Heyland D, Joynt G, Français A, Azeivedo-Maia P, Owczuk R, Benbenishty J, de Vita M, Valentin A, Ksomos A, Cohen S, Kompan L, Ho K, Abroug F, Kaarlola A, Gerlach H, Kyprianou T, Michalsen A, Chevret S, Schlemmer B. Prevalence and factors of intensive care unit conflicts: the conflicus study. Am J Respir Crit Care Med. 2009;180:853–860. doi: 10.1164/rccm.200810-1614OC.
    1. Embriaco N, Azoulay E, Barrau K, Kentish N, Pochard F, Loundou A, Papazian L. High level of burnout in intensivists: prevalence and associated factors. Am J Respir Crit Care Med. 2007;175:686–692. doi: 10.1164/rccm.200608-1184OC. Epub 2007 Jan 2018.
    1. Poncet MC, Toullic P, Papazian L, Kentish-Barnes N, Timsit JF, Pochard F, Chevret S, Schlemmer B, Azoulay E. Burnout syndrome in critical care nursing staff. Am J Respir Crit Care Med. 2007;175:698–704. doi: 10.1164/rccm.200606-806OC. Epub 2006 Nov 2016.
    1. Pochard F, Grassin M, Azoulay E: Ethical principles for everyone.Ann Intern Med 2001, 134:1152. discussion 1152–1153.
    1. Pochard F, Grassin M, Herve C. Palliative options at the end of life. Jama. 1998;279:1065–1066. doi: 10.1001/jama.279.14.1065. discussion 1066–1067.
    1. Pochard F, Grassin M, Kentish-Barnes N, Azoulay E. Patient autonomy and the end of life. Crit Care Med. 2003;31:662–663. doi: 10.1097/.
    1. Whitney SN. A new model of medical decisions: exploring the limits of shared decision making. Med Decis Making. 2003;23:275–280. doi: 10.1177/0272989X03256006.
    1. Goldstein NE, Back AL, Morrison RS. Titrating guidance: a model to guide physicians assisting patients and families facing complex decisions. Arch Intern Med. 2008;168:1733–1739. doi: 10.1001/archinte.168.16.1733.
    1. Whitney SN, McGuire AL, McCullough LB. A typology of shared decision making, informed consent, and simple consent. Ann Intern Med. 2004;140:54–59. doi: 10.7326/0003-4819-140-1-200401060-00012.
    1. Lautrette A, Darmon M, Megarbane B, Joly LM, Chevret S, Adrie C, Barnoud D, Bleichner G, Bruel C, Choukroun G, Curtis JR, Fieux F, Galliot R, Garrouste-Orgeas M, Georges H, Goldgran-Toledano D, Jourdain M, Loubert G, Reignier J, Saidi F, Souweine B, Vincent F, Barnes NK, Pochard F, Schlemmer B, Azoulay E. A communication strategy and brochure for relatives of patients dying in the ICU. N Engl J Med. 2007;356:469–478. doi: 10.1056/NEJMoa063446.
    1. Lilly CM, Daly BJ. The healing power of listening in the ICU. N Engl J Med. 2007;356:513–515. doi: 10.1056/NEJMe068253.
    1. Azoulay E, Pochard F: Meeting the needs of intensive care unit patients' family members: beyond satisfaction.Crit Care Med 2002, 30:2171.
    1. Azoulay E. The end-of-life family conference: communication empowers. Am J Respir Crit Care Med. 2005;171:803–804. doi: 10.1164/rccm.2501004.
    1. Jones C. What's new on the post-ICU burden for patients and relatives? Intensive Care Med. 2013;39:1832–1835. doi: 10.1007/s00134-013-3015-8.
    1. Puntillo K, Nelson JE, Weissman D, Curtis R, Weiss S, Frontera J, Gabriel M, Hays R, Lustbader D, Mosenthal A, Mulkerin C, Ray D, Bassett R, Boss R, Brasel K, Campbell M. Palliative care in the ICU: relief of pain, dyspnea, and thirst—a report from the IPAL-ICU advisory board. Intensive Care Med. 2013;40:235–248. doi: 10.1007/s00134-013-3153-z.
    1. Gelinas C, Chanques G, Puntillo K. In pursuit of pain: recent advances and future directions in pain assessment in the ICU. Intensive Care Med. 2014;40:1009–1014. doi: 10.1007/s00134-014-3299-3.
    1. Yaguchi A, Truog RD, Curtis JR, Luce JM, Levy MM, Melot C, Vincent JL. International differences in end-of-life attitudes in the intensive care unit: results of a survey. Arch Intern Med. 2005;165:1970–1975. doi: 10.1001/archinte.165.17.1970.
    1. Ferrand E, Lemaire F, Regnier B, Kuteifan K, Badet M, Asfar P, Jaber S, Chagnon JL, Renault A, Robert R, Pochard F, Herve C, Brun-Buisson C, Duvaldestin P. Discrepancies between perceptions by physicians and nursing staff of intensive care unit end-of-life decisions. Am J Respir Crit Care Med. 2003;167:1310–1315. doi: 10.1164/rccm.200207-752OC. Epub 2003 Jan 1324.
    1. McDonagh JR, Elliott TB, Engelberg RA, Treece PD, Shannon SE, Rubenfeld GD, Patrick DL, Curtis JR. Family satisfaction with family conferences about end-of-life care in the intensive care unit: increased proportion of family speech is associated with increased satisfaction. Crit Care Med. 2004;32:1484–1488. doi: 10.1097/01.CCM.0000127262.16690.65.
    1. Curtis JR, Engelberg RA, Wenrich MD, Shannon SE, Treece PD, Rubenfeld GD. Missed opportunities during family conferences about end-of-life care in the intensive care unit. Am J Respir Crit Care Med. 2005;171:844–849. doi: 10.1164/rccm.200409-1267OC. Epub 2005 Jan 2007.
    1. Levy MM, De Backer D. Re-visiting visiting hours. Intensive Care Med. 2013;39:2223–2225. doi: 10.1007/s00134-013-3119-1.
    1. Azoulay E, Pochard F, Chevret S, Jourdain M, Bornstain C, Wernet A, Cattaneo I, Annane D, Brun F, Bollaert PE, Zahar JR, Goldgran-Toledano D, Adrie C, Joly LM, Tayoro J, Desmettre T, Pigne E, Parrot A, Sanchez O, Poisson C, Le Gall JR, Schlemmer B, Lemaire F. Impact of a family information leaflet on effectiveness of information provided to family members of intensive care unit patients: a multicenter, prospective, randomized, controlled trial. Am J Respir Crit Care Med. 2002;165:438–442. doi: 10.1164/ajrccm.165.4.200108-006oc.
    1. Schnell D, Abadie S, Toullic P, Chaize M, Souppart V, Poncet MC, Schlemmer B, Azoulay E. Open visitation policies in the ICU: experience from relatives and clinicians. Intensive Care Med. 2013;39:1873–1874. doi: 10.1007/s00134-013-2956-2.
    1. McAdam JL, Arai S, Puntillo KA. Unrecognized contributions of families in the intensive care unit. Intensive Care Med. 2008;34:1097–1101. doi: 10.1007/s00134-008-1066-z.
    1. Clinton BK, Silverman BC, Brendel DH. Patient-targeted googling: the ethics of searching online for patient information. Harv Rev Psychiatry. 2010;18:103–112. doi: 10.3109/10673221003683861.
    1. Lilly CM, De Meo DL, Sonna LA, Haley KJ, Massaro AF, Wallace RF, Cody S. An intensive communication intervention for the critically ill. Am J Med. 2000;109:469–475. doi: 10.1016/S0002-9343(00)00524-6.
    1. Lilly CM, Sonna LA, Haley KJ, Massaro AF. Intensive communication: four-year follow-up from a clinical practice study. Crit Care Med. 2003;31:S394–S399. doi: 10.1097/01.CCM.0000065279.77449.B4.
    1. Fallowfield L, Jenkins V, Farewell V, Saul J, Duffy A, Eves R. Efficacy of a Cancer Research UK communication skills training model for oncologists: a randomised controlled trial. Lancet. 2002;359:650–656. doi: 10.1016/S0140-6736(02)07810-8.
    1. Arnold RM, Kellum J. Moral justifications for surrogate decision making in the intensive care unit: implications and limitations. Crit Care Med. 2003;31:S347–S353. doi: 10.1097/01.CCM.0000065123.23736.12.
    1. Fried TR, Bradley EH, Towle VR, Allore H. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002;346:1061–1066. doi: 10.1056/NEJMsa012528.
    1. Puntillo KA, Benner P, Drought T, Drew B, Stotts N, Stannard D, Rushton C, Scanlon C, White C. End-of-life issues in intensive care units: a national random survey of nurses' knowledge and beliefs. Am J Crit Care. 2001;10:216–229.
    1. Robinson SM, Mackenzie-Ross S, Campbell Hewson GL, Egleston CV, Prevost AT. Psychological effect of witnessed resuscitation on bereaved relatives. Lancet. 1998;352:614–617. doi: 10.1016/S0140-6736(97)12179-1.
    1. Lundin T. Long-term outcome of bereavement. Br J Psychiatry. 1984;145:424–428. doi: 10.1192/bjp.145.4.424.
    1. Maciejewski PK, Zhang B, Block SD, Prigerson HG. An empirical examination of the stage theory of grief. Jama. 2007;297:716–723. doi: 10.1001/jama.297.7.716.
    1. Jones C, Skirrow P, Griffiths RD, Humphris G, Ingleby S, Eddleston J, Waldmann C, Gager M. Post-traumatic stress disorder-related symptoms in relatives of patients following intensive care. Intensive Care Med. 2004;30:456–460. doi: 10.1007/s00134-003-2149-5. Epub 2004 Feb 2004.

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