Use of dexmedetomidine for pain control

Irina Grosu, Patricia Lavand'homme, Irina Grosu, Patricia Lavand'homme

Abstract

For many years, clonidine, an α2-adrenergic receptor (α2-AR) agonist, has been widely used as an analgesic adjuvant in perioperative conditions and pain therapy. Dexmedetomidine (DMET) is currently the most potent α2-AR agonist available and was first approved as a sedative agent for use in the intensive care unit. However, DMET has recently been investigated for its analgesic effects and has the potential to become an alternative to clonidine.

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    2. F1000 Factor 6

      Evaluated by Mike Crowder 05 May 2009

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    2. Changes Clinical Practice

      F1000 Factor 17

      Evaluated by Anne-Cornelie de Pont 25 Feb 2009, Babak Sarani 09 Mar 2009, Keira Mason 11 Mar 2009, Alain Vuylsteke 24 Mar 2009, Matthias Eikermann 23 Apr 2009

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    2. F1000 Factor 6

      Evaluated by Malachy Columb 26 Oct 2009

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    2. F1000 Factor 6

      Evaluated by Keira Mason 21 Jan 2010

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    2. F1000 Factor 6

      Evaluated by Pekka Talke 10 Jul 2008

Source: PubMed

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