Clinical Indications of C-Choline PET/CT in Prostate Cancer Patients with Biochemical Relapse

Maria Picchio, Paolo Castellucci, Maria Picchio, Paolo Castellucci

Abstract

Several studies investigated the potential role of imaging modalities in prostate cancer patients in case of biochemical recurrence. However, the role of molecular imaging has not been well established yet. Considering the results of the literature and of our own experience, we tried to summarize the potential applications of (11)C-choline PET/CT in prostate cancer patients in case of biochemical relapse for the detection of lymph node and distant recurrence.

Keywords: choline PET/CT; prostate cancer; restaging..

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Fig 1
Fig 1
68y.o. patient. Prostate Cancer T3aN1Mx. Biochemical relapse two years after radical prostatectomy. PSA = 1.3 ng/mL at the time of 11C-Choline PET/CT. PSAdt = 3 months. 11C-Choline PET /CT detected a single positive lymph-node in the left iliac chain. a) CT images, a small sub-centimetric LN is evident in the left iliac chain b) focal increased uptake of 11C-Choline in the left iliac chain c) fused images d) MIP.
Fig 2
Fig 2
76 y.o. patient. Biochemical relapse 9 years after radical prostatectomy. PSA 1,43 ng/mL at the time of the Bone Scan and 11C-Choline PET/CT. a) The bone scan showed focal uptake in the left clavicle and the right pelvis. b) PET/CT also showed 11C-choline uptake in the same > sites, which were evident on CT (pictures c and d).

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