The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: A prospective randomized clinical trial

Azita Tehranchi, Hossein Behnia, Fereydoun Pourdanesh, Parsa Behnia, Nelson Pinto, Farnaz Younessian, Azita Tehranchi, Hossein Behnia, Fereydoun Pourdanesh, Parsa Behnia, Nelson Pinto, Farnaz Younessian

Abstract

Objective: The aim of this study was to evaluate the effect of LPRF, placed in extraction sockets, on orthodontic tooth movement (OTM).

Materials and methods: Thirty extraction sockets from eight patients (five males, three females, with a mean age of 17.37 years; range 12-25 years) requiring extraction of first premolars based on their orthodontic treatment plan participated in this split-mouth clinical trial. In one randomly selected quadrant of each jaw, the extraction socket was preserved as the experimental group by immediate placement of LPRF in the extraction socket. The other quadrant served as the control group for secondary healing. Immediately, the teeth adjacent to the defects were pulled together by a NiTi closed-coil spring with constant force. A piece of 0.016 × 0.022-inch stainless steel wire was used as the main arch wire. The amount of OTM was measured on the study casts at eight time points with 2-week intervals for 3 months. Analysis of random effect model was performed for the purpose of comparison between the experimental and control groups.

Results: According to the random effect model, a statistically significant difference was found between the experimental and control group in rate of OTM (P = 0.006).

Conclusion: According to the results, application of LPRF, as an interdisciplinary approach combining orthodontics and surgery, may accelerate OTM, particularly in extraction cases.

Keywords: Leukocyte platelet rich fibrin; orthodontic tooth movement; plasma; platelet concentrate; platelet-rich fibrin; platelet-rich plasma.

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Collection of venous blood from the brachial vein using a 10 mL syringe. (b) Platelets are trapped massively in the fibrin mesh
Figure 2
Figure 2
(a) The extraction socket was preserved by immediate placement of LPRF in the extraction socket as the experimental group and the other side served as the control group for secondary healing. (b) The exact amount of tooth movement were measured on the study casts using a digital caliper
Figure 3
Figure 3
Amount the distance between marginal ridges of the teeth adjacent to sockets in millimeters at different time points. Data represent the mean values in the experimental and control groups

References

    1. Singh A, Kohli M, Gupta N. Platelet rich fibrin: A novel approach for osseous regeneration. J Maxillofac Oral Surg. 2012;11:430–4.
    1. Hatakeyama I, Marukawa E, Takahashi Y, Omura K. Effects of platelet-poor plasma, platelet-rich plasma, and platelet-rich fibrin on healing of extraction sockets with buccal dehiscence in dogs. Tissue Eng Part A. 2014;20:874–82.
    1. Marrelli M, Tatullo M. Influence of PRF in the healing of bone and gingival tissues. Clinical and histological evaluations. Eur Rev Med Pharmacol Sci. 2013;17:1958–62.
    1. Schliephake H. Clinical efficacy of growth factors to enhance tissue repair in oral and maxillofacial reconstruction: A systematic review. Clin Implant Dent Relat Res. 2015;17:247–73.
    1. Suttapreyasri S, Leepong N. Influence of platelet-rich fibrin on alveolar ridge preservation. J Craniofac Surg. 2013;24:1088–94.
    1. Hoaglin DR, Lines GK. Prevention of localized osteitis in mandibular third-molar sites using platelet-rich fibrin. Int J Dent 2013. 2013:875380.
    1. Del Fabbro M, Corbella S, Taschieri S, Francetti L, Weinstein R. Autologous platelet concentrate for post-extraction socket healing: A systematic review. Eur J Oral Implantol. 2014;7:333–44.
    1. Del Corso M, Mazor Z, Rutkowski JL, Dohan Ehrenfest DM. The use of leukocyte- and platelet-rich fibrin during immediate postextractive implantation and loading for the esthetic replacement of a fractured maxillary central incisor. J Oral Implantol. 2012;38:181–7.
    1. Chang YC, Zhao JH. Effects of platelet-rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects. Aust Dent J. 2011;56:365–71.
    1. Sammartino G, Dohan Ehrenfest DM, Carile F, Tia M, Bucci P. Prevention of hemorrhagic complications after dental extractions into open heart surgery patients under anticoagulant therapy: The use of leukocyte- and platelet-rich fibrin. J Oral Implantol. 2011;37:681–90.
    1. Taschieri S, Del Fabbro M. Postextraction osteotome sinus floor elevation technique using plasma-rich growth factors. Implant Dent. 2011;20:418–24.
    1. Ruga E, Gallesio C, Boffano P. Platelet-rich fibrin and piezoelectric surgery: A safe technique for the prevention of periodontal complications in third molar surgery. J Craniofac Surg. 2011;22:1951–5.
    1. Del Corso M, Vervelle A, Simonpieri A, Jimbo R, Inchingolo F, Sammartino G, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: Periodontal and dentoalveolar surgery. Curr Pharm Biotechnol. 2012;13:1207–30.
    1. Simonpieri A, Del Corso M, Vervelle A, Jimbo R, Inchingolo F, Sammartino G, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol. 2012;13:1231–56.
    1. Schär MO, Diaz-Romero J, Kohl S, Zumstein MA, Nesic D. Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro. Clin Orthop Relat Res. 2015;473:1635–43.
    1. Simon BI, Gupta P, Tajbakhsh S. Quantitative evaluation of extraction socket healing following the use of autologous platelet-rich fibrin matrix in humans. Int J Periodontics Restorative Dent. 2011;31:285–95.
    1. Baeyens W, Glineur R, Evrard L. The use of platelet concentrates: Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in bone reconstruction prior to dental implant surgery. Rev Med Brux. 2010;31:521–7.
    1. Peck MT, Marnewick J, Stephen L. Alveolar ridge preservation using leukocyte and platelet-rich fibrin: A report of a case. Case Rep Dent 2011. 2011;345048
    1. Huang FM, Yang SF, Zhao JH, Chang YC. Platelet-rich fibrin increases proliferation and differentiation of human dental pulp cells. J Endod. 2010;36:1628–32.
    1. Yuan X, Luo S, Shen G. Experimental study on selecting optimal time of orthodontic tooth movement into extraction sites. Hua Xi Kou Qiang Yi Xue Za Zhi. 2003;21:311–3.
    1. Kocyigit ID, Tuz HH, Alp YE, Atil F, Tekin U, Coskunses FM, et al. Correction of postsurgical alveolar ridge defect with vertical alveolar distraction of the onlay block graft. J Craniofac Surg. 2012;23:1550–2.
    1. Gürbüzer B, Pikdöken L, Tunali M, Urhan M, Küçükodaci Z, Ercan F, et al. Scintigraphic evaluation of osteoblastic activity in extraction sockets treated with platelet-rich fibrin. J Oral Maxillofac Surg. 2010;68:980–9.
    1. Dohan Ehrenfest DM, Bielecki T, Jimbo R, Barbé G, Del Corso M, Inchingolo F, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates?. An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF) Curr Pharm Biotechnol. 2012;13:1145–52.
    1. Liou EJ. The development of submucosal injection of platelet rich plasma for accelerating orthodontic tooth movement and preserving pressure side alveolar bone. APOS Trends Orthod. 2016;6:5.
    1. Güleç A, Bakkalbaşı BÇ, Cumbul A, Uslu Ü, Alev B, Yarat A, et al. Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: A histomorphometric study. Am J Orthod Dentofacial Orthop. 2017;151:92–104.
    1. Rashid A, ElSharaby FA, Nassef EM, Mehanni S, Mostafa YA. Effect of platelet-rich plasma on orthodontic tooth movement in dogs. Orthod Craniofac Res. 2017;20:102–10.
    1. Munoz F, Jiménez C, Espinoza D, Vervelle A, Beugnet J, Haidar Z, et al. Use of leukocyte and platelet-rich fibrin (L-PRF) in periodontally accelerated osteogenic orthodontics (PAOO): Clinical effects on edema and pain. J Clin Exp Dent. 2016;8:e119–24.
    1. Alfawal AM, Hajeer MY, Ajaj MA, Hamadah O, Brad B. Effectiveness of minimally invasive surgical procedures in the acceleration of tooth movement: A systematic review and meta-analysis. Prog Orthod. 2016;17:33.
    1. Campbell JH. Periodontally accelerated osteogenic orthodontics. J Oral Maxillofac Surg. 2017;75:6.
    1. Tsai CY, Yang TK, Hsieh HY, Yang LY. Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats. Angle Orthod. 2016;86:558–64.
    1. Alikhani M, Raptis M, Zoldan B, Sangsuwon C, Lee YB, Alyami B, et al. Effect of micro-osteoperforations on the rate of tooth movement. Am J Orthod Dentofacial Orthop. 2013;144:639–48.
    1. Hoffmann S, Papadopoulos N, Visel D, Visel T, Jost-Brinkmann PG, Präger TM, et al. Influence of piezotomy and osteoperforation of the alveolar process on the rate of orthodontic tooth movement: A systematic review. J Orofac Orthop. 2017;78:301–11.
    1. Cheung T, Park J, Lee D, Kim C, Olson J, Javadi S, et al. Ability of mini-implant-facilitated micro-osteoperforations to accelerate tooth movement in rats. Am J Orthod Dentofacial Orthop. 2016;150:958–67.
    1. McBride MD, Campbell PM, Opperman LA, Dechow PC, Buschang PH. How does the amount of surgical insult affect bone around moving teeth? Am J Orthod Dentofacial Orthop. 2014;145:S92–9.
    1. Simon D, Manuel S, Geetha V, Naik BR. Potential for osseous regeneration of platelet-rich plasma – A comparative study in mandibular third molar sockets. Indian J Dent Res. 2004;15:133–6.
    1. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR, et al. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:638–46.
    1. Rebentish PD, Umashetty G, Kaur H, Doizode T, Kaslekar M, Chowdhury S, et al. Platelet-rich fibrin: A boon in regenerative endodontics. Minerva Stomatol. 2016;65:385–92.
    1. Varghese MP, Manuel S, Kumar LK. Potential for osseous regeneration of platelet-rich fibrin-A comparative study in mandibular third molar impaction sockets. J Oral Maxillofac Surg. 2017;75:1322–9.
    1. Alagl A, Bedi S, Hassan K, AlHumaid J. Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation. J Int Med Res. 2017;45:583–93.
    1. Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: From the wound healing to bone regeneration. Immun Ageing. 2013;10:23.
    1. Arenaz-Búa J, Luaces-Rey R, Sironvalle-Soliva S, Otero-Rico A, Charro-Huerga E, Patiño-Seijas B, et al. A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction. Med Oral Patol Oral Cir Bucal. 2010;15:e483–9.
    1. Rutkowski JL, Johnson DA, Radio NM, Fennell JW. Platelet rich plasma to facilitate wound healing following tooth extraction. J Oral Implantol. 2010;36:11–23.
    1. Célio-Mariano R, de Melo WM, Carneiro-Avelino C. Comparative radiographic evaluation of alveolar bone healing associated with autologous platelet-rich plasma after impacted mandibular third molar surgery. J Oral Maxillofac Surg. 2012;70:19–24.
    1. Weibrich G, Hansen T, Kleis W, Buch R, Hitzler WE. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone. 2004;34:665–71.
    1. Marx RE. Platelet-rich plasma: Evidence to support its use. J Oral Maxillofac Surg. 2004;62:489–96.
    1. El-Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, et al. Platelet-rich plasma: Growth factors and pro- and anti-inflammatory properties. J Periodontol. 2007;78:661–9.
    1. Andia I, Maffulli N. Platelet-rich plasma for managing pain and inflammation in osteoarthritis. Nat Rev Rheumatol. 2013;9:721–30.

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