Localization of dysfunction in major depressive disorder: prefrontal cortex and amygdala
Elisabeth A Murray, Steven P Wise, Wayne C Drevets, Elisabeth A Murray, Steven P Wise, Wayne C Drevets
Abstract
Despite considerable effort, the localization of dysfunction in major depressive disorder (MDD) remains poorly understood. We present a hypothesis about its localization that builds on recent findings from primate neuropsychology. The hypothesis has four key components: a deficit in the valuation of "self" underlies the core disorder in MDD; the medial frontal cortex represents "self"; interactions between the amygdala and cortical representations update their valuation; and inefficiency in using positive feedback by orbital prefrontal cortex contributes to MDD.
Published by Elsevier Inc.
Figures
Source: PubMed