Exploratory study of the effectiveness of nebulised saline in children with neurodisability

Natalia Galaz Souza, Andrew Bush, Hui-Leng Tan, Natalia Galaz Souza, Andrew Bush, Hui-Leng Tan

Abstract

The prescription of nebulised saline in children and young people with neurodisability was associated with improved respiratory outcomes and was favourably received by patients and their caregivers https://bit.ly/3mSyzag

Trial registration: ClinicalTrials.gov NCT03623698.

Conflict of interest statement

Conflict of interest: N. Galaz Souza has nothing to disclose. Conflict of interest: A. Bush has nothing to disclose. Conflict of interest: H-L. Tan has nothing to disclose.

References

    1. Van Ruiten HJ, Marini Bettolo C, Cheetham T, et al. . Why are some patients with Duchenne muscular dystrophy dying young: an analysis of causes of death in North East England. Eur J Paediatr Neurol 2016; 20: 904–909. doi:10.1016/j.ejpn.2016.07.020
    1. LoMauro A, Aliverti A, Mastella C, et al. . Spontaneous breathing pattern as respiratory functional outcome in children with spinal muscular atrophy (SMA). PLoS One 2016; 11: e0165818. doi:10.1371/journal.pone.0165818
    1. Allen J. Pulmonary complications of neuromuscular disease: a respiratory mechanics perspective. Paediatr Respir Rev 2010; 11: 18–23. doi:10.1016/j.prrv.2009.10.002
    1. Wark P, McDonald VM. Nebulised hypertonic saline for cystic fibrosis. Cochrane Database Syst Rev 2018; 9: CD001506.
    1. Stahl M, Wielpütz MO, Ricklefs I, et al. . Preventive Inhalation of Hypertonic Saline in Infants with Cystic Fibrosis (PRESIS). A randomized, double-blind, controlled study. Am J Respir Crit Care Med 2019; 199: 1238–1248. doi:10.1164/rccm.201807-1203OC
    1. Trimble AT, Whitney Brown A, Laube BL, et al. . Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis. J Cyst Fibros 2018; 17: 650–656. doi:10.1016/j.jcf.2018.01.001
    1. Ratjen F, Davis SD, Stanojevic S, et al. . Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2019; 7: 802–809. doi:10.1016/S2213-2600(19)30187-0
    1. Nicolson CH, Stirling RG, Borg BM, et al. . The long term effect of inhaled hypertonic saline 6% in non-cystic fibrosis bronchiectasis. Respir Med 2012; 106: 661–667. doi:10.1016/j.rmed.2011.12.021
    1. Zhang L, Mendoza-Sassi RA, Wainwright C, et al. . Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev 2017; 12: CD006458.
    1. Angoulvant F, Bellêttre X, Milcent K, et al. . Effect of nebulized hypertonic saline treatment in emergency departments on the hospitalization rate for acute bronchiolitis: a randomized clinical trial. JAMA Pediatr 2017; 171: e171333. doi:10.1001/jamapediatrics.2017.1333
    1. Goralski JL, Wu D, Thelin WR, et al. . The in vitro effect of nebulised hypertonic saline on human bronchial epithelium. Eur Respir J 2018; 51: 1702652. doi:10.1183/13993003.02652-2017
    1. Reeves EP, McCarthy C, McElvaney OJ, et al. . Inhaled hypertonic saline for cystic fibrosis: reviewing the potential evidence for modulation of neutrophil signalling and function. World J Crit Care Med 2015; 4: 179–191. doi:10.5492/wjccm.v4.i3.179
    1. Aitken ML, Greene KE, Tonelli MR, et al. . Analysis of sequential aliquots of hypertonic saline solution-induced sputum from clinically stable patients with cystic fibrosis. Chest 2003; 123: 792–799. doi:10.1378/chest.123.3.792
    1. Wright FL, Gamboni F, Moore EE, et al. . Hyperosmolarity invokes distinct anti-inflammatory mechanisms in pulmonary epithelial cells: evidence from signaling and transcription layers. PLoS One 2014; 9: e114129. doi:10.1371/journal.pone.0114129
    1. Michon AL, Jumas-Bilak E, Chiron R, et al. . Advances toward the elucidation of hypertonic saline effects on Pseudomonas aeruginosa from cystic fibrosis patients. PLoS One 2014; 9: e90164. doi:10.1371/journal.pone.0090164
    1. Bergsson G, Reeves EP, McNally P, et al. . LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline. J Immunol 2009; 183: 543–551. doi:10.4049/jimmunol.0803959
    1. Williams HD, Behrends V, Bundy JG, et al. . Hypertonic saline therapy in cystic fibrosis: do population shifts caused by the osmotic sensitivity of infecting bacteria explain the effectiveness of this treatment? Front Microbiol 2010; 1: 120. doi:10.3389/fmicb.2010.00120
    1. Smyth AR, Barbato A, Beydon N, et al. . Respiratory medicines for children: current evidence, unlicensed use and research priorities. Eur Respir J 2010; 35: 247–265. doi:10.1183/09031936.00139508
    1. Chen YL, Chiou WK, Tzeng YT, et al. . A rating of perceived exertion scale using facial expressions for conveying exercise intensity for children and young adults. J Sci Med Sport 2017; 20: 66–69. doi:10.1016/j.jsams.2016.05.009

Source: PubMed

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