Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China
Jinzhong Li, Xiaobing Gong, Zhigang Wang, Renzhou Chen, Taoyuan Li, Dongyu Zeng, Minran Li, Jinzhong Li, Xiaobing Gong, Zhigang Wang, Renzhou Chen, Taoyuan Li, Dongyu Zeng, Minran Li
Abstract
An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs.
Keywords: 2019 Coronavirus disease; Cluster-onset families; SARS-Coronavirus-2; Solitary-onset families.
Conflict of interest statement
The authors have no competing of interest nor any financial interest in any product mentioned in this paper.
Copyright © 2020. Published by Elsevier B.V.
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