Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts

Olaoluwa Okusaga, Robert H Yolken, Patricia Langenberg, Manana Lapidus, Timothy A Arling, Faith B Dickerson, Debra A Scrandis, Emily Severance, Johanna A Cabassa, Theodora Balis, Teodor T Postolache, Olaoluwa Okusaga, Robert H Yolken, Patricia Langenberg, Manana Lapidus, Timothy A Arling, Faith B Dickerson, Debra A Scrandis, Emily Severance, Johanna A Cabassa, Theodora Balis, Teodor T Postolache

Abstract

Background: Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking.

Methods: Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ² tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes.

Results: Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p=0.001) and history of psychotic symptoms (p=0.005).

Limitations: The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed.

Conclusions: The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.

Copyright © 2010 Elsevier B.V. All rights reserved.

References

    1. Arborelius L., Owens M.J., Plotsky P.M., Nemeroff C.B. The role of corticotropin-releasing factor in depression and anxiety disorders. J. Endocrinol. 1999;160:1–12.
    1. Arbour N., Day R., Newcombe J., Talbot P.J. Neuroinvasion by human respiratory coronaviruses. J. Virol. 2000;74:8913–8921.
    1. Azorin J.-M., Kaladjian A., Besnier N., Adida M., Hantouche E., Lancrenon S., Akiskal H. Suicidal behavior in a French Cohort of major depressive patients: characteristics of attempters and nonattempters. J. Affect. Disord. 2009 Sep 30, [Epub ahead of print]
    1. Basco M.R. Is there a place for research diagnostic methods in clinic settings? In: First M.B., editor. Standardized Evaluation in Clinical Practice (Review of Psychiatry Series) American Psychiatric Publishing; Washington, D.C.: 2003. pp. 1–28.
    1. Beautrais A.L., Joyce P.R., Mulder R.T., Fergusson D.M., Deavoll B.J., Nightingale S.K. Prevalence and comorbidity of mental disorders in persons making serious suicide attempts: a case-control study. Am. J. Psychiatry. 1996;153:1009–1014.
    1. Besedovsky H., Rey A.D., Sorkin E., Dinarello C.A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science. 1986;233:652–654.
    1. Besedovsky H.O., Rey A.D., Klusman I., Furukawa H., Monge A.G., Kabiersch A. Cytokines as modulators of the hypothalamus-pituitary-adrenal axis. J. Steroid Biochem. Mol. Biol. 1991;40:613–618.
    1. Butel J.S. Orthomyxoviruses (Influenza Viruses) In: Brooks G.F., Carroll K.C., Butel J.S., Morse S.A., editors. Jawetz, Melnick, & Adelberg's Medical Microbiology. The McGraw-Hill Companies; New York: 2007. pp. 533–539.
    1. Capuron L., Neurauter G., Musselman D.L., Lawson D.H., Nemeroff C.B., Fuchs D., Miller A.H. Interferon-alpha-induced changes in tryptophan metabolism: relationship to depression and paroxetine treatment. Biol. Psychiatry. 2003;54:906–914.
    1. Capuron L., Fornwalt F.B., Knight B.T., Harvey P.D., Ninan P.T., Miller A.H. Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals? J. Affect. Disord. 2009;119:181–185.
    1. Dantzer R. Cytokine-induced sickness behavior: where do we stand? Brain. Behav. Immun. 2001;15:7–24.
    1. Dantzer R., O'connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008;9:46–56.
    1. Dessau R.B., Lisby G., Frederiksen J.L. Coronaviruses in brain tissue from patients with multiple sclerosis. Acta Neuropathol. 2001;101:601–604.
    1. Dolin R. Influenza. In: Fauci A.S., Braunwald E., Kasper D.L., Hauser S.L., Longo D.L., Jameson J.L., Loscalzo J., editors. Harrison's Principles of Internal Medicine. McGraw-Hill Companies; New York: 2008. pp. 1127–1131.
    1. Dursun S.M., Blackburn J.R., Kutcher S.P. An exploratory approach to the serotonergic hypothesis of depression: bridging the synaptic gap. Med. Hypotheses. 2001;56:235–243.
    1. Ellman L.M., Yolken R.H., Buka S.L., Torrey E.F., Cannon T.D. Cognitive functioning prior to the onset of psychosis: the role of fetal exposure to serologically determined influenza infection. Biol. Psychiatry. 2009;65:1040–1047.
    1. Fujimoto S., Kobayashi M., Uemura O., Iwasa M., Ando T., Katoh T., Nakamura C., Maki N., Togari H., Wada Y. PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet. 1998;352:873–875.
    1. Gelder M., Mayou R., Cowen P. Oxford University Press; New York: 2001. Shorter Oxford Textbook of Psychiatry.
    1. Gold P.W., Licinio J., Wong M.L., Chrousos G.P. Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs. Ann. NY Acad. Sci. 1995;771:716–729.
    1. Harrison R.M. Post-influenzal depression. Br. Med. J. 1958;1:460.
    1. Haukka J., Suominen K., Partonen T., Lonnqvist J. Determinants and outcomes of serious attempted suicide: a nationwide study in Finland, 1996–2003. Am. J. Epidemiol. 2008;167:1155–1163.
    1. Hiroi N., Wong M.L., Licinio J., Park C., Young M., Gold P.W., Chrousos G.P., Bornstein S.R. Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. Mol. Psychiatry. 2001;6:540–546.
    1. Kahn J.S. The widening scope of coronaviruses. Curr. Opin. Pediatr. 2006;18:42–47.
    1. Kessler R.C., Chiu W.T., Demler O., Walters E.E. Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R) Arch. Gen. Psychiatry. 2005;62:617–627.
    1. Levinson W. The McGraw-Hill Companies Inc; New York: 2008. Review of Medical Microbiology and Immunology.
    1. Licinio J., Wong M.-L. The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection. Mol. Psychiatry. 1999;4:317–327.
    1. Lishman W.A. Blackwell Science; Oxford, UK: 1997. Organic psychiatry: the psychological consequences of cerebral disorder.
    1. Lopez A.D., Mathers C.D. Measuring the global burden of disease and epidemiological transitions: 2002–2030. Ann. Trop. Med. Parasitol. 2006;100:481–499.
    1. Mann J.J. Neurobiology of suicidal behaviour. Nat. Rev. Neurosci. 2003;4:819–828.
    1. Marques-Deak A., Cizza G., Sternberg E. Brain-immune interactions and disease susceptibility. Mol. Psychiatry. 2005;10:239–250.
    1. Matsubara K., Kodera M., Nigami H., Yura K., Fukaya T. Reversible splenial lesion in influenza virus encephalopathy. Pediatr. Neurol. 2007;37:431–434.
    1. Maurizi C.P. Influenza and mania: a possible connection with the locus ceruleus. South. Med. J. 1985;78:207–209.
    1. McCullers J.A., Facchini S., Chesney P.J., Webster R.G. Influenza B virus encephalitis. Clin. Infect. Dis. 1999;28:898–900.
    1. Miura T.A., Holmes K.V. Host-pathogen interactions during coronavirus infection of primary alveolar-epithelial cells. J. Leukoc. Biol. 2009;86:1–7.
    1. Nelson R.J., Demas G.E., Klein S.L., Kriegsfeld L.J. Cambridge University Press; Cambridge, UK: 2005. Seasonal patterns of stress, immune function and disease.
    1. Nicholson K.G., Wood J.M., Zambon M. Influenza. Lancet. 2003;362:1733–1745.
    1. Oquendo M.A., Halberstam B., Mann J.J. Risk factors for suicidal behavior: the utility and limitations of research instruments. In: First M.B., editor. Standardized Evaluation in Clinical Practice (Review of Psychiatry Series) American Psychiatric Publishing; Washington, DC: 2003. pp. 103–130.
    1. Postolache T.T., Mortensen P.B., Tonelli L.H., Jiao X., Frangakis C., Soriano J.J., Qin P. Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders. J. Affect. Disord. 2010;121:88–93.
    1. SAS [computer program]. Version 9.1. Cary (NC): SAS Institute Inc; 2008.
    1. Seasonal Influenza: The Disease [Online]. 2009 Sep 8 [cited 2009 Dec 30]; Available from: URL:.
    1. Severance E.G., Bossis I., Dickerson F.B., Stallings C.R., Origoni A.E., Sullens A., Yolken R.H., Viscidi R.P. Development of a nucleocapsid-based human coronavirus immunoassay and estimates of individuals exposed to coronavirus in a U.S. metropolitan population. Clin Vaccine Immunol. 2008;215:1805–1810.
    1. Severance E.G., Dickerson F.B., Viscidi R.P., Bossis I., Stallings C.R., Origoni A.E., Sullens A., Yolken R.H. Coronavirus immunoreactivity in individuals with a recent onset of psychotic symptoms. Schizophr. Bull. 2009 e-pub ahead of print 2 Jun 2009.
    1. Steinberg D., Hirsch S.R., Marston S.D., Reynolds K., Sutton N.P. Influenza infection causing manic psychosis. Br. J. Psychiatry. 1972;120:531–535.
    1. Tonelli L.H., Postolache T.T. Airborne inflammatory factors: from the nose to the brain. Front. Biosci. 2010;S2:135–152.
    1. Tuke D.H. J. & A. Churchill; London, UK: 1892. Dictionary of Psychological Medicine.
    1. Vollmer-Conna U. Acute sickness behaviour: an immune system-to-brain communication? Psychol. Med. 2001;31:761–767.
    1. Wang J., Dunn A.J. Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism. Neurochem. Int. 1998;33:143–154.
    1. Whitlock F.A. The neurology of affective disorder and suicide. Aust. N. Z. J. Psychiatry. 1982;16:1–12.
    1. Wichers M., Maes M. Psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans. Int. J. Neuropsychopharmacol. 2002;5:375–388.
    1. Xu J., Zhong S., Liu J., Li L., Li Y., Wu X., Li Z., Deng P., Zhang J., Zhong N., Ding Y., Jiang Y. Detection of severe acute respiratory syndrome corona virus in the brain: potential role of the chemokine migration in pathogenesis. Clin. Infect. Dis. 2005;41:1089–1096.
    1. Yeh A., Arlene C., Cohen M.E., Duffner P.K., Faden H. Detection of corona virus in the central nervous system of a child with acute disseminated encephalomyelitis. Pediatrics. 2004;113:73–76.
    1. Zhilinskaya I.N., Maklakova A.S., Ashmarin I.P. M-Protein as a possible inducer of depressive state in influenza. Dokl. Biol. Sci. 2002;387:556–558.

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