Clinical Assessment of Fatigability in Multiple Sclerosis: A Shift from Perception to Performance

Bryant A Seamon, Michael O Harris-Love, Bryant A Seamon, Michael O Harris-Love

No abstract available

Keywords: clinical assessment; fatigability; fatigue; multiple sclerosis; rehabilitation; task performance.

Figures

Figure 1
Figure 1
Hierarchy chart depicting the general steps for associating clinical assessments of fatigability with overall fatigue in individuals with MS. Self-reported measures of perceived fatigue do not consistently correspond to performance-based measures of fatigability. Valid functional measures of fatigue must be associated with accepted estimates of fatigability and viable for use in rehabilitation settings. Better understanding of the relationship between the performance-based criterion measures and the trait characteristic of fatigability may aid our approach to the assessment and treatment of those people with multiple sclerosis. Notes: *Examples of criterion measures include the duration of task sustainability, rate of change in force production, power, voluntary activation, reaction times, heart rate, mean arterial pressure, core temperature, and outcomes of muscle morphology. †Examples of functional performance tests include the Adult Myopathy Assessment Test (AMAT), Short Physical Performance Battery Protocol (SPPB), and Dalgas’ Functional Capacity Test (FCT). ‡Examples of state variables include the exercise prescription, modality of exercise, and exercise environment. §Examples of intervention to manipulate a state variable: a progressive resistance exercise program or an aerobic endurance exercise program.

References

    1. Amato MP, Portaccio E. Management options in multiple sclerosis-associated fatigue. Expert Opin Pharmacother (2012) 13:207–16.10.1517/14656566.2012.647767
    1. Bakshi R. Fatigue associated with multiple sclerosis: diagnosis, impact and management. Mult Scler (2003) 9:219–27.10.1191/1352458503ms904oa
    1. Minden SL, Frankel D, Hadden L, Perloffp J, Srinath KP, Hoaglin DC. The Sonya Slifka Longitudinal Multiple Sclerosis Study: methods and sample characteristics. Mult Scler (2006) 12:24–38.10.1191/135248506ms1262oa
    1. Ford H, Trigwell P, Johnson M. The nature of fatigue in multiple sclerosis. J Psychosom Res (1998) 45:33–8.10.1016/S0022-3999(98)00004-X
    1. Janardhan V, Bakshi R. Quality of life in patients with multiple sclerosis: the impact of fatigue and depression. J Neurol Sci (2002) 205:51–8.10.1016/S0022-510X(02)00312-X
    1. Motl RW, McAuley E. Symptom cluster as a predictor of physical activity in multiple sclerosis: preliminary evidence. J Pain Symptom Manage (2009) 38:270–80.10.1016/j.jpainsymman.2008.08.004
    1. Motl RW, McAuley E, Wynn D, Suh Y, Weikert M. Effects of change in fatigue and depression on physical activity over time in relapsing-remitting multiple sclerosis. Psychol Health Med (2011) 16:1–11.10.1080/13548506.2010.521569
    1. Putzki N, Katsarava Z, Vago S, Diener HC, Limmroth V. Prevalence and severity of multiple-sclerosis-associated fatigue in treated and untreated patients. Eur Neurol (2008) 59:136–42.10.1159/000111876
    1. Téllez N, Río J, Tintoré M, Nos C, Galán I, Montalban X. Does the modified fatigue impact scale offer a more comprehensive assessment of fatigue in MS? Mult Scler (2005) 11:198–202.10.1191/1352458505ms1148oa
    1. Kluger BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology (2013) 80:409–16.10.1212/WNL.0b013e31827f07be
    1. Enoka RM, Duchateau J. Translating fatigue to human performance. Med Sci Sports Exerc (2016) 48:2228–38.10.1249/MSS.0000000000000929
    1. Edwards RHT. Human muscle function and fatigue. In: Porter R, Whelan J, editors. Novartis Foundation Symposia. Chichester: John Wiley & Sons, Ltd. (2016). p. 1–18. Available from:
    1. Enoka RM, Stuart DG. Neurobiology of muscle fatigue. J Appl Physiol (1985) (1992) 72:1631–48.
    1. Dittner AJ, Wessely SC, Brown RG. The assessment of fatigue: a practical guide for clinicians and researchers. J Psychosom Res (2004) 56:157–70.10.1016/S0022-3999(03)00371-4
    1. Latimer-Cheung AE, Pilutti LA, Hicks AL, Martin Ginis KA, Fenuta AM, MacKibbon KA, et al. Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development. Arch Phys Med Rehabil (2013) 94:1800–28.e3.10.1016/j.apmr.2013.04.020
    1. Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet Lond Engl (2004) 363:978–88.10.1016/S0140-6736(04)15794-2
    1. Rampello A, Franceschini M, Piepoli M, Antenucci R, Lenti G, Olivieri D, et al. Effect of aerobic training on walking capacity and maximal exercise tolerance in patients with multiple sclerosis: a randomized crossover controlled study. Phys Ther (2007) 87:545–55.10.2522/ptj.20060085
    1. Surakka J, Romberg A, Ruutiainen J, Aunola S, Virtanen A, Karppi S-L, et al. Effects of aerobic and strength exercise on motor fatigue in men and women with multiple sclerosis: a randomized controlled trial. Clin Rehabil (2004) 18:737–46.10.1191/0269215504cr780oa
    1. Bergamaschi R, Romani A, Versino M, Poli R, Cosi V. Clinical aspects of fatigue in multiple sclerosis. Funct Neurol (1997) 12:247–51.
    1. Savci S, Inal-Ince D, Arikan H, Guclu-Gunduz A, Cetisli-Korkmaz N, Armutlu K, et al. Six-minute walk distance as a measure of functional exercise capacity in multiple sclerosis. Disabil Rehabil (2005) 27:1365–71.10.1080/09638280500164479
    1. Motl RW, Balantrapu S, Pilutti L, Dlugonski D, Suh Y, Sandroff BM, et al. Symptomatic correlates of six-minute walk performance in persons with multiple sclerosis. Eur J Phys Rehabil Med (2013) 49:59–66.
    1. Kalron A. Association between perceived fatigue and gait parameters measured by an instrumented treadmill in people with multiple sclerosis: a cross-sectional study. J Neuroeng Rehabil (2015) 12:34.10.1186/s12984-015-0028-2
    1. Hobart J, Cano S, Baron R, Thompson A, Schwid S, Zajicek J, et al. Achieving valid patient-reported outcomes measurement: a lesson from fatigue in multiple sclerosis. Mult Scler (2013) 19:1773–83.10.1177/1352458513483378
    1. Steens A, de Vries A, Hemmen J, Heersema T, Heerings M, Maurits N, et al. Fatigue perceived by multiple sclerosis patients is associated with muscle fatigue. Neurorehabil Neural Repair (2012) 26:48–57.10.1177/1545968311416991
    1. Sutherland G, Andersen MB. Exercise and multiple sclerosis: physiological, psychological, and quality of life issues. J Sports Med Phys Fitness (2001) 41:421–32.
    1. Andreasen A, Stenager E, Dalgas U. The effect of exercise therapy on fatigue in multiple sclerosis. Mult Scler (2011) 17:1041–54.10.1177/1352458511401120
    1. Steens A, Heersema DJ, Maurits NM, Renken RJ, Zijdewind I. Mechanisms underlying muscle fatigue differ between multiple sclerosis patients and controls: a combined electrophysiological and neuroimaging study. Neuroimage (2012) 59:3110–8.10.1016/j.neuroimage.2011.11.038
    1. Motl RW, Learmonth YC, Wójcicki TR, Fanning J, Hubbard EA, Kinnett-Hopkins D, et al. Preliminary validation of the short physical performance battery in older adults with multiple sclerosis: secondary data analysis. BMC Geriatr (2015) 15:157.10.1186/s12877-015-0156-3
    1. Harris-Love MO, Fernandez-Rhodes L, Joe G, Shrader JA, Kokkinis A, La Pean Kirschner A, et al. Assessing function and endurance in adults with spinal and bulbar muscular atrophy: validity of the adult myopathy assessment tool. Rehabil Res Pract (2014) 2014:1–16.10.1155/2014/873872
    1. Dalgas U, Stenager E, Jakobsen J, Petersen T, Hansen HJ, Knudsen C, et al. Resistance training improves muscle strength and functional capacity in multiple sclerosis. Neurology (2009) 73:1478–84.10.1212/WNL.0b013e3181bf98b4
    1. Dalgas U, Stenager E, Jakobsen J, Petersen T, Hansen H, Knudsen C, et al. Fatigue, mood and quality of life improve in MS patients after progressive resistance training. Mult Scler (2010) 16:480–90.10.1177/1352458509360040
    1. Kent-Braun JA, Ng AV, Castro M, Weiner MW, Gelinas D, Dudley GA, et al. Strength, skeletal muscle composition, and enzyme activity in multiple sclerosis. J Appl Physiol (1985) (1997) 83:1998–2004.
    1. Wens I, Dalgas U, Vandenabeele F, Krekels M, Grevendonk L, Eijnde BO. Multiple sclerosis affects skeletal muscle characteristics. PLoS One (2014) 9:e108158.10.1371/journal.pone.0108158
    1. Visser M, Kritchevsky SB, Goodpaster BH, Newman AB, Nevitt M, Stamm E, et al. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc (2002) 50:897–904.10.1046/j.1532-5415.2002.50217.x
    1. Goodpaster BH, Kelley DE, Thaete FL, He J, Ross R. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol (2000) 89:104–10.
    1. Ismail C, Zabal J, Hernandez HJ, Woletz P, Manning H, Teixeira C, et al. Diagnostic ultrasound estimates of muscle mass and muscle quality discriminate between women with and without sarcopenia. Front Physiol (2015) 6:302.10.3389/fphys.2015.00302
    1. Fukumoto Y, Ikezoe T, Yamada Y, Tsukagoshi R, Nakamura M, Mori N, et al. Skeletal muscle quality assessed from echo intensity is associated with muscle strength of middle-aged and elderly persons. Eur J Appl Physiol (2012) 112:1519–25.10.1007/s00421-011-2099-5

Source: PubMed

Спонсоры и соавторы

Заболевания

Медикаментозные вмешательства

Подписаться