Chromium and cobalt ion concentrations in blood and serum following various types of metal-on-metal hip arthroplasties: a literature overview

Christopher Jantzen, Henrik L Jørgensen, Benn R Duus, Sune L Sporring, Jes B Lauritzen, Christopher Jantzen, Henrik L Jørgensen, Benn R Duus, Sune L Sporring, Jes B Lauritzen

Abstract

Background and purpose: Widely different metal ion concentrations in blood and serum have been reported with metal-on-metal (MoM) implants. We reviewed the literature on blood and serum ion concentrations of chromium (Cr) and cobalt (Co) following various MoM hip arthroplasties.

Methods: Studies were searched for in the Medline database, Embase, and the Cochrane Database of Systematic Reviews. Highest mean or median ion concentrations of Cr and Co after a minimum of 1 year of follow-up were extracted and grouped according to sample- and articulation type, and average values were calculated.

Results: 43 studies were included and 16 different MoM implants were identified. For the different types of bearings, average ion concentrations and range were calculated from the mean or median ion concentration. The average Cr concentration ranged between 0.5 and 2.5 μg/L in blood and between 0.8 and 5.1 μg/L in serum. For Co, the range was 0.7-3.4 μg/L in blood and 0.3-7.5 μg/L in serum.

Interpretation: When the average blood ion concentrations calculated for the different implants, together with the concentrations measured in the individual studies, were compared with the upper acceptable limit for Cr and Co in blood, no clear pattern was recognized. Furthermore, we were unable to detect any clear difference in ion concentrations between different types of implants (THA and resurfacing).

Figures

Figure 1.
Figure 1.
Flow diagram illustrating the study selection process.
Figure 2.
Figure 2.
Average Cr concentration and range, calculated from medians, in blood (red) and serum (blue) following various types of MoM hip arthroplasties.
Figure 3.
Figure 3.
Average Co concentration and range, calculated from medians, in blood (red) and serum (blue) following various types of MoM hip arthroplasties.
Figure 4.
Figure 4.
Average Cr concentration and range, calculated from means, in blood (red) and serum (blue) following various types of MoM hip arthroplasties.
Figure 5.
Figure 5.
Average Co concentration and range, calculated from means, in blood (red) and serum (blue) following various types of MoM hip arthroplasties.*upper range 10.1 μg/L.

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