Implant survival after surgical treatment of peri-implantitis lesions by means of deproteinized bovine bone mineral with 10% collagen: 10-year results from a prospective study

Mario Roccuzzo, Ludovica Fierravanti, Dario Pittoni, Paola Dalmasso, Andrea Roccuzzo, Mario Roccuzzo, Ludovica Fierravanti, Dario Pittoni, Paola Dalmasso, Andrea Roccuzzo

Abstract

Objectives: To evaluate the 10-year outcomes of a regenerative surgical treatment of single peri-implantitis intrabony defects, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).

Material and methods: The original population consisted of 26 patients with one crater-like defect, around either SLA or TPS dental implants, with a probing depth ≥6 mm and no implant mobility. After debridement and surface decontamination, the defects were filled with DBBMC. Subsequently, patients were placed in an individualized supportive peri-implant/periodontal therapy (SPT) program.

Results: Fourteen patients (eight SLA and six TPS) reached the 10-year examination. The overall implant survival rate was 67%, 80% for the SLA, and 55% for the TPS implants. During SPT, five patients were lost to follow-up, eight patients needed additional antibiotic and/or surgical therapy, and seven patients had the implant removed. PD was reduced from 6.6 ± 1.3 to 3.2 ± 0.7 mm in SLA and from 7.2 ± 1.5 to 3.4 ± 0.6 mm in TPS. BOP decreased from 75.0 ± 31.2% to 7.5 ± 12.1% (SLA) and from 90.0 ± 12.9% to 30.0 ± 19.7% (TPS). Treatment success was found in 5 of the 12 SLA (42%) and in 4 of the 14 TPS (29%).

Conclusions: The proposed reconstructive treatment, followed by SPT, was able to maintain in function the majority of SLA implants, although the overall treatment success was limited and many of TPS implants were removed. Therefore, the decision to treat implants affected by peri-implantitis should be based on several factors, including surface characteristics.

Keywords: biomaterial; bone substitute; defect fill; peri-implantitis; surgical treatment.

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

References

REFERENCES

    1. Albouy, J. P., Abrahamsson, I., Persson, L. G., & Berglundh, T. (2011). Implant surface characteristics influence the outcome of treatment of peri-implantitis: An experimental study in dogs. Journal of Clinical Periodontology, 38, 58-64.
    1. Almohandes, A., Carcuac, O., Abrahamsson, I., Lund, H., & Berglundh, T. (2019). Re-osseointegration following reconstructive surgical therapy of experimental peri-implantitis. A pre-clinical in vivo study. Clinical Oral Implants Research, 30(5), 447-456.
    1. Andersen, H., Aass, A. M., & Wohlfahrt, J. C. (2017). Porous titanium granules in the treatment of peri-implant osseous defects-a 7-year follow-up study. International Journal of Implant Dentistry, 3(1), 50.
    1. Berglundh, T., Wennström, J. L., & Lindhe, J. (2018). Long-term outcome of surgical treatment of peri-implantitis. A 2-11-year retrospective study. Clinical Oral Implants Research, 29(4), 404-410.
    1. Bianchini, M. A., Galarraga-Vinueza, M. E., Apaza-Bedoya, K., De Souza, J. M., Magini, R., & Schwarz, F. (2019). Two to six-year disease resolution and marginal bone stability rates of a modified resective-implantoplasty therapy in 32 peri-implantitis cases. Clinical Implant Dentistry and Related Research, 21(4), 758-765.
    1. Bornstein, M. M., Schmid, B., Belser, U. C., Lussi, A., & Buser, D. (2005). Early loading of non-submerged titanium implants with a sandblasted and acid-etched surface. 5-year results of a prospective study in partially edentulous patients. Clinical Oral Implants Research, 16(6), 631-638.
    1. Carcuac, O., Abrahamsson, I., Charalampakis, G., & Berglundh, T. (2015). The effect of the local use of chlorhexidine in surgical treatment of experimental peri-implantitis in dogs. Journal of Clinical Periodontology, 42(2), 196-203.
    1. Carcuac, O., Derks, J., Abrahamsson, I., Wennström, J. L., Petzold, M., & Berglundh, T. (2017). Surgical treatment of peri-implantitis: 3-year results from a randomized controlled clinical trial. Journal of Clinical Periodontology, 44(12), 1294-1303.
    1. Carcuac, O., Derks, J., Charalampakis, G., Abrahamsson, I., Wennström, J., & Berglundh, T. (2016). Adjunctive systemic and local antimicrobial therapy in the surgical treatment of peri-implantitis: A randomized controlled clinical trial. Journal of Dental Research, 95(1), 50-57.
    1. Chan, H.-L., Lin, G.-H., Suárez, F., MacEachern, M., & Wang, H.-L. (2014). Surgical management of peri-implantitis: A systematic review and meta-analysis of treatment outcomes. Journal of Periodontology, 85(8), 1027-1041.
    1. Cortellini, P., Buti, J., Pini Prato, G., & Tonetti, M. S. (2017). Periodontal regeneration compared with access flap surgery in human intra-bony defects 20-year follow-up of a randomized clinical trial: Tooth retention, periodontitis recurrence and costs. Journal of Clinical Periodontology, 44(1), 58-66.
    1. Dalago, H. R., Schuldt Filho, G., Rodrigues, M. A., Renvert, S., & Bianchini, M. A. (2017). Risk indicators for peri-implantitis. A cross-sectional study with 916 implants. Clinical Oral Implants Research, 28, 144-150.
    1. Derks, J., & Tomasi, C. (2015). Peri-implant health and disease. A systematic review of current epidemiology. Journal of Clinical Periodontology, 42(Suppl. 16), S158-171.
    1. Faggion, C. M. Jr, Listl, S., Frühauf, N., Chang, H. J., & Tu, Y. K. (2014). A systematic review and Bayesian network meta-analysis of randomized clinical trials on non-surgical treatments for peri-implantitis. Journal of Clinical Periodontology, 41(10), 1015-1025.
    1. Fletcher, P., Deluiz, D., Tinoco, E. M., Ricci, J. L., Tarnow, D. P., & Tinoco, J. M. (2017). human histologic evidence of reosseointegration around an implant affected with peri-implantitis following decontamination with sterile saline and antiseptics: A case history report. International Journal of Periodontics and Restorative Dentistry, 37(4), 499-508.
    1. Heitz-Mayfield, L. J., Aaboe, M., Araujo, M., Carrión, J. B., Cavalcanti, R., Cionca, N., … Yeo, A. (2018). Group 4 ITI Consensus Report: Risks and biologic complications associated with implant dentistry. Clinical Oral Implants Research, 29(Suppl. 16), 351-358.
    1. Heitz-Mayfield, L. J. A., Heitz, F., & Lang, N. P. (2020). Implant Disease Risk Assessment IDRA-a tool for preventing peri-implant disease. Clinical Oral Implants Research, 31(4), 397-403.
    1. Heitz-Mayfield, L. J. A., Salvi, G. E., Mombelli, A., Loup, P. J., Heitz, F., Kruger, E., & Lang, N. P. (2018). Supportive peri-implant therapy following anti-infective surgical peri-implantitis treatment: 5-year survival and success. Clinical Oral Implants Research, 29(1), 1-6.
    1. Isehed, C., Svenson, B., Lundberg, P., & Holmlund, A. (2018). Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3-and 5-year follow-up. Journal of Clinical Periodontology, 45, 744-753.
    1. Khoshkam, V., Chan, H. L., Lin, G. H., MacEachern, M. P., Monje, A., Suarez, F., … Wang, H. L. (2013). Reconstructive procedures for treating peri-implantitis: A systematic review. Journal of Dental Research, 92(Suppl. 12), 131S-S138.
    1. Khoshkam, V., Suárez-López Del Amo, F., Monje, A., Lin, G. H., Chan, H. L., & Wang, H. L. (2016). Long-term radiographic and clinical outcomes of regenerative approach for treating peri-implantitis: A systematic review and meta-analysis. International Journal of Oral & Maxillofacial Implants, 31(6), 1303-1310.
    1. Khoury, F., & Buchmann, R. (2001). Surgical therapy of peri-implant disease: A 3-year follow-up study of cases treated with 3 different techniques of bone regeneration. Journal of Periodontology, 72(11), 1498-1508.
    1. La Monaca, G., Pranno, N., Annibali, S., Cristalli, M. P., & Polimeni, A. (2018). Clinical and radiographic outcomes of a surgical reconstructive approach in the treatment of peri-implantitis lesions: A 5-year prospective case series. Clinical Oral Implants Research, 29(10), 1025-1037.
    1. Mercado, F., Hamlet, S., & Ivanovski, S. (2018). Regenerative surgical therapy for peri-implantitis using deproteinized bovine bone mineral with 10% collagen, enamel matrix derivative and Doxycycline-A prospective 3-year cohort study. Clinical Oral Implants Research, 29(6), 583-591.
    1. Mombelli, A., & Lang, N. P. (1998). The diagnosis and treatment of peri-implantitis. Periodontology, 2000(17), 63-76.
    1. Monje, A., Aranda, L., Diaz, K. T., Alarcón, M. A., Bagramian, R. A., Wang, H. L., & Catena, A. (2016). Impact of maintenance therapy for the prevention of peri-implant diseases: A systematic review and meta-analysis. Journal of Dental Research, 95(4), 372-379.
    1. Persson, L. G., Berglundh, T., Sennerby, L., & Lindhe, J. (2001). Reosseointegration after treatment of peri-implantitis at different implant surfaces. An experimental study in the dog. Clinical Oral Implant Research, 12(6), 595-603.
    1. Rakic, M., Galindo-Moreno, P., Monje, A., Radovanovic, S., Wang, H. L., Cochran, D., … Canullo, L. (2018). How frequent does peri-implantitis occur? A systematic review and meta-analysis. Clinical Oral Investigation, 22(4), 1805-1816.
    1. Renvert, S., Lindahl, C., & Persson, G. R. (2018). Occurrence of cases with peri-implant mucositis or peri-implantitis in a 21-26 years follow-up study. Journal of Clinical Periodontology, 45, 233-240.
    1. Roccuzzo, M., Bonino, F., Bonino, L., & Dalmasso, P. (2011). Surgical therapy of peri-implantitis lesions by means of a bovine-derived xenograft: Comparative results of a prospective study on two different implant surfaces. Journal of Clinical Periodontology, 38, 738-745.
    1. Roccuzzo, M., Bunino, M., Prioglio, F., & Bianchi, S. D. (2001). Early loading of sandblasted and acid-etched (SLA) implants: A prospective split-mouth comparative study. Clinical Oral Implant Research, 12(6), 572-578.
    1. Roccuzzo, M., Gaudioso, L., Lungo, M., & Dalmasso, P. (2016). Surgical therapy of single peri-implantitis intrabony defects, by means of deproteinized bovine bone mineral with 10% collagen. Journal of Clinical Periodontology, 43, 311-318.
    1. Roccuzzo, M., Layton, D. M., Roccuzzo, A., & Heitz-Mayfield, L. J. (2018). Clinical outcomes of peri-implantitis treatment and supportive care: A systematic review. Clinical Oral Implants Research., 29(Suppl.16), 331-350.
    1. Roccuzzo, M., Marchese, S., Dalmasso, P., & Roccuzzo, A. (2018). Periodontal regeneration and orthodontic treatment of severely periodontally compromised teeth: 10-year results of a prospective study. International Journal Periodontics Restorative Dentistry, 38(6), 801-809.
    1. Roccuzzo, M., Pittoni, D., Roccuzzo, A., Charrier, L., & Dalmasso, P. (2017). Surgical treatment of peri-implantitis intrabony lesions by means of deproteinized bovine bone mineral with 10% collagen: 7-year-results. Clinical Oral Implants Research, 28(12), 1577-1583.
    1. Rokn, A., Aslroosta, H., Akbari, S., Najafi, H., Zayeri, F., & Hashemi, K. (2016). Prevalence of peri-implantitis in patients not participating in well-designed supportive periodontal treatments: A cross-sectional study. Clinical Oral Implants Research, 28(3), 314-319.
    1. Roos-Jansåker, A. M., Persson, G. R., Lindahl, C., & Renvert, S. (2014). Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: A 5-year follow-up. Journal of Clinical Periodontology, 41, 1108-1114.
    1. Roos-Jansåker, A. M., Renvert, H., Lindahl, C., & Renvert, S. (2007). Submerged healing following surgical treatment of peri-implantitis: A case series. Journal of Clinical Periodontology, 34(8), 723-727.
    1. Schwarz, F., Becker, K., Sahm, N., Horstkemper, T., Rousi, K., & Becker, J. (2017). The prevalence of peri-implant diseases for two-piece implants with an internal tube-in-tube connection: A cross-sectional analysis of 512 implants. Clinical Oral Implants Research, 28, 24-28.
    1. Schwarz, F., Derks, J., Monje, A., & Wang, H. L. (2018). Peri-implantitis. Journal of Clinical Periodontology, 45(6), S246-S266.
    1. Schwarz, F., John, G., Mainusch, S., Sahm, N., & Becker, J. (2012). Combined surgical therapy of peri-implantitis evaluating two methods of surface debridement and decontamination. A two-year clinical follow up report. Journal of Clinical Periodontology, 39(8), 789-797.
    1. Schwarz, F., John, G., Schmucker, A., Sahm, N., & Becker, J. (2017). Combined surgical therapy of advanced peri-implantitis evaluating two methods of surface decontamination: A 7-year follow-up observation. Journal of Clinical Periodontology, 44(3), 337-342.
    1. Schwarz, F., Sahm, N., Schwarz, K., & Becker, J. (2010). Impact of defect configuration on the clinical outcome following surgical regenerative therapy of peri-implantitis. Journal of Clinical Periodontology, 37(5), 449-455.
    1. Tomasi, C., Regidor, E., Ortiz-Vigón, A., & Derks, J. (2019). Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis. Journal of Clinical Periodontology, 46(Suppl. 21), 340-356.
    1. Vignoletti, F., Di Domenico, G. L., Di Martino, M., Montero, E., & de Sanctis, M. (2019). Prevalence and risk indicators of peri-implantitis in a sample of university-based dental patients in Italy: A cross-sectional study. Journal of Clinical Periodontology, 46(5), 597-605.

Source: PubMed

Спонсоры и соавторы

Заболевания

Медикаментозные вмешательства

Подписаться