Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia, March to June 2014

AbdulSalam A Noorwali, AbdulHafiz M Turkistani, Sari I Asiri, Fadel A Trabulsi, Osama M Alwafi, Saud H Alzahrani, Muhammad M Rashid, Safwat A Hegazy, Mohammed D Alzaydi, Khalid O Bawakid, AbdulSalam A Noorwali, AbdulHafiz M Turkistani, Sari I Asiri, Fadel A Trabulsi, Osama M Alwafi, Saud H Alzahrani, Muhammad M Rashid, Safwat A Hegazy, Mohammed D Alzaydi, Khalid O Bawakid

Abstract

Background and objectives: Describe the epidemiology and characteristics of Middle East respiratory syndrome coronavirus (MERS-CoV), which are essential for control and treatment.

Methods: We conducted a retrospective review of all cases of MERS-CoV reported in four cities of the Makkah Region from March to June 2014. Exposure factors and comorbid conditions were analyzed using Epi Info.

Results: Analysis of the 261 cases revealed that the incidence peaked in mid-April 2014 and the fatality rate was 42%. Cough, fever, radiological evidence of pneumonia, and shortness of breath were identified as significant risk factors for a diagnosis of MER-CoV infection. Healthcare workers (HCWs) are at a higher risk of acquiring MERS-CoV than non-HCWs. Males in Jeddah are at higher risk due to greater outdoor exposure while females in Taif are at higher risk due to domestic caregiving. Filipino nurses are at highest risk among all HCWs.

Conclusion: The findings indicate the need to screen all contacts of HCWs to improve MERS control and form public-private partnerships to investigate the true burden of MERS.

Figures

Figure 1
Figure 1
Sex distribution of confirmed cases of MERS in the Makkah Region, March–June 2014.
Figure 2
Figure 2
Outcomes of confirmed cases of MERS-CoV infection in the Makkah Region, March–June 2014.
Figure 3
Figure 3
Distribution of cases of healthcare workers and non healthcare workers in the Makkah Region, March–June 2014.

References

    1. Hemida MG, Chu DKW, Poon LML, Perera RAPM, Alhammadi MA, Ng HY, et al. MERS coronavirus in dromedary camel herd, Saudi Arabia. Emerg Infect Dis. 2014;20(7):1231–4.
    1. Memish ZA, Zumla AI, Al-Hakeem RF, Al-Rabeeah AA, Stephens GM. Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med. 2013;368(26):2487–94.
    1. Cotton M, Lam TT, Watson SJ, Palser AL, Petrova V, Grant P, et al. Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus. Emerg Infect Dis. 2013;19(5):736–42.
    1. Perera RA, Wang P, Gomaa MR, El-Shesheny R, Kandeil A, Bagato O, et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill. 2013;18(36) pii-20574.
    1. Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, Al-Rabiah FA, Al-Hajjar S, Al-Barrak A, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013;13(9):752–61.
    1. Saad M, Omrani AS, Baig K, Bahloul A, Elzein F, Matin MA, et al. Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia. Int J Infect Dis. 2014 pii:S1201-9712(14)01622-1.
    1. WHO Regional Office for Europe (EURO), N.I.F.P.f.T. Middle East respiratory syndrome coronavirus (MERS-CoV)–Turkey. 2014. (cited 2014 Oct 29).
    1. Guery PB, Poissy J, el Mansouf L, Séjourné C, Ettahar N, Lemaire X, et al. Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission. Lancet. 2013;381(9885):2265–72.
    1. Hijawi B, Abdallat M, Sayaydeh A, Alqasrawi S, Haddadin N, Jaarour N, et al. Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation. East Mediterr Health J. 2013;19(Suppl 1):S12–8.
    1. Kraaij–Dirkzwager M, Timen A, Dirksen K, Gelinck L, Leyten E, Groeneveld P, et al. Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands, May 2014. Euro Surveill. 2014;19(21)
    1. Al-Tawfiq JA, Zumla A, Memish ZA. Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers. Curr Opin Infect Dis. 2014;27(5):411–7.
    1. Omrani AS, Matinb MA, Haddadc Q, Al-Nakhlid D, Memishe ZA, Albarraka AM, et al. A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case. Int J Infect Dis. 2013;17(9):e668–72.
    1. Memish ZA, Assiri A, Alhakeem R, Yezli S, Almasri M, Zumla A, et al. Middle East respiratory syndrome corona virus, MERS-CoV. Int J Infect Dis; Conclusions from the 2nd Scientific Advisory Board Meeting of the WHO Collaborating Center for Mass Gathering Medicine; Riyadh. 2014. pp. 51–3.
    1. Gautret P, Vu Hai V, Sani S, Doutchi M, Parola P, Brouqui P, et al. Protective measures against acute respiratory symptoms in French pilgrims participating in the Hajj of 2009. J Travel Med. 2011;18(1):53–5.
    1. Al-Tawfiq JA, Zumla A, Memish ZA. Respiratory tract infections during the annual Hajj: potential risks and mitigation strategies. Curr Opin Pulm Med. 2013;19(3):192–7.
    1. Health Protection Agency (HPA) UK Novel Coronavirus Investigation team. Evidence of person-to-person transmission within a family cluster of novel coronavirus infections, United Kingdom, February 2013. Euro Surveill. 2013;18(11):20427.
    1. Mailles A, Blanckaert K, Chaud P, van der Werf S, Lina B, Caro V, et al. First cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission, France, May 2013. Euro Surveill. 2013;18(24) pii:20502.
    1. Bauch CT, Oraby T. Assessing the pandemic potential of MERS-CoV. Lancet. 2013;382(9893):662–4.
    1. Al-Tawfiq JA, Zumla A, Gautret P, Gray GC, Hui DS, Al-Rabeeah AA, et al. Surveillance for emerging respiratory viruses. Lancet Infect Dis. 2014;14(10):992–1000.
    1. de Groot RJ, Baker SC, Ziebuhr J. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol. 2013;87(14):7790–2.
    1. Madani TA. Case definition and management of patients with MERS coronavirus in Saudi Arabia. Lancet Infect Dis. 2014;14(10):911–3.
    1. Al-Abdallat MM, Payne DC, Alqasrawi S, Rha B, Tohme RA, Abedi GR, et al. Hospital-associated outbreak of middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clin Infect Dis. 2014;59(9):1225–33.
    1. Drosten C, Meyer B, Müller MA, Corman VM, Al-Masri M, Hossain R, et al. Transmission of MERS-coronavirus in household contacts. N Engl J Med. 2014;371(9):828–35.
    1. Al-Tawfiq JA1, Assiri A, Memish ZA. Middle East respiratory syndrome novel corona MERS-CoV infection. Epidemiology and outcome update. Saudi Med J. 2013;34(10):991–4.

Source: PubMed

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